• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of brmedjLink to Publisher's site
Br Med J. Mar 9, 1974; 1(5905): 436–440.
PMCID: PMC1633246

A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction

Abstract

The results of a randomized controlled trial of a single daily dose of acetyl salicylic acid (aspirin) in the prevention of reinfarction in 1,239 men who had had a recent myocardial infarct were statistically inconclusive. Nevertheless, they showed a reduction in total mortality of 12% at six months and 25% at twelve months after admission to the trial. Further trials are urgently required to establish whether or not this effect is real.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Weiss HJ, Aledort LM. Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet. 1967 Sep 2;2(7514):495–497. [PubMed]
  • O'Brien JR. Effects of salicylates on human platelets. Lancet. 1968 Apr 13;1(7546):779–783. [PubMed]
  • Davies DT, Hughes A, Tonks RS. Salicylates, platelets and adenine nucleotides. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;259(2):163–164. [PubMed]
  • CUTLER SJ, EDERER F. Maximum utilization of the life table method in analyzing survival. J Chronic Dis. 1958 Dec;8(6):699–712. [PubMed]
  • BORN GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962 Jun 9;194:927–929. [PubMed]
  • O'Brien JR, Heywood JB, Heady JA. The quantitation of platelet aggregation induced by four compounds: a study in relation to myocardial infarction. Thromb Diath Haemorrh. 1966 Dec 1;16(3):752–767. [PubMed]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...