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Br Med J. Mar 9, 1974; 1(5905): 436–440.
PMCID: PMC1633246

A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction


The results of a randomized controlled trial of a single daily dose of acetyl salicylic acid (aspirin) in the prevention of reinfarction in 1,239 men who had had a recent myocardial infarct were statistically inconclusive. Nevertheless, they showed a reduction in total mortality of 12% at six months and 25% at twelve months after admission to the trial. Further trials are urgently required to establish whether or not this effect is real.

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Selected References

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  • Weiss HJ, Aledort LM. Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet. 1967 Sep 2;2(7514):495–497. [PubMed]
  • O'Brien JR. Effects of salicylates on human platelets. Lancet. 1968 Apr 13;1(7546):779–783. [PubMed]
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