• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Arch Dis Child. Nov 1980; 55(11): 845–850.
PMCID: PMC1626957

Survival and handicap of infants with spina bifida.

Abstract

A follow-up study was carried out on 213 infants born with spina bifida cystica (including encephalocele and occipital meningocele) from 1965 to 1972 to women resident in Oxfordshire and the western part of Berkshire. The 5-year survival rate was 36% (39/107) for those with open lesions, 60% (30/50) for those with closed ones, and 18% (10/56) for those with lesions which could not be classified (not known) but which were probably nearly all open. The extent of handicap among these survivors was assessed by means of criteria described by Lorber; among those with open lesions (including 'not known') 84% (41/49) were severely handicapped, 10% (4/49) were moderately handicapped, and only 6% (3/49) had no handicap; among those with closed lesions, 37% (11/30) were severely handicapped, 33% (10/30) were moderately handicapped, and the remaining 30% (9/30) were not handicapped. Closed head lesions (encephalocele or occipital meningocele) were more often associated with severe handicap (6/8; 75%) than were closed spinal lesions (5/22; 23%). The children with open lesions who survived for at least 5 years spent, on average, at least 6 months in hospital during the first 5 years of their life and had, on average, at least 6 major surgical operations. In comparison, those with closed lesions spent one-third less time in hospital, and had fewer than half as many operations. During the period of the study a selective treatment policy was adopted typical of that commonly practised now, and all the infants were born before antenatal screening had been introduced. Our results therefore may be helpful in assessing the benefits to be expected from antenatal screening for open spina bifida.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (908K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Lorber J. Results of treatment of myelomeningocele. An analysis of 524 unselected cases, with special reference to possible selection for treatment. Dev Med Child Neurol. 1971 Jun;13(3):279–303. [PubMed]
  • Mawdsley T, Rickham PP, Roberts JR. Long-term results of early operation of open myelomeningoceles and encephaloceles. Br Med J. 1967 Mar 18;1(5541):663–666. [PMC free article] [PubMed]
  • Knox EG. Spina bifida in Birmingham. Dev Med Child Neurol. 1967;(Suppl):14–22. [PubMed]
  • Hagard S, Carter F, Milne RG. Screening for spina bifida cystica. A cost-benefit analysis. Br J Prev Soc Med. 1976 Mar;30(1):40–53. [PMC free article] [PubMed]
  • Lightowler CD. Meningomyelocele: the price of treatment. Br Med J. 1971 May 15;2(5758):385–387. [PMC free article] [PubMed]
  • Layde PM, von Allmen SD, Oakley GP., Jr Maternal serum alpha-fetoprotein screening: a cost-benefit analysis. Am J Public Health. 1979 Jun;69(6):566–573. [PMC free article] [PubMed]
  • Baldwin JA. The Oxford Record Linkage Study as a medical information system. Proc R Soc Med. 1972 Mar;65(3):237–239. [PMC free article] [PubMed]
  • Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. [PMC free article] [PubMed]
  • Stark GD, Drummond M. Results of selective early operation in myelomeningocele. Arch Dis Child. 1973 Sep;48(9):676–683. [PMC free article] [PubMed]
  • Laurence KM. Effect of early surgery for spina bifida cystica on survival and quality of life. Lancet. 1974 Feb 23;1(7852):301–304. [PubMed]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...