• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of amjphAmerican Journal of Public Health Web SiteAmerican Public Health Association Web SiteSubmissionsSubscriptionsAbout Us
Am J Public Health. 1995 December; 85(12): 1706–1709.
PMCID: PMC1615747

The reporting sensitivities of two passive surveillance systems for vaccine adverse events.

Abstract

To evaluate reporting sensitivities for vaccine adverse events, reporting rates were estimated by dividing the number of events reported to the Monitoring System for Adverse Events Following Immunization and the Vaccine Adverse Event Reporting System in a given period by the number of doses administered or distributed during the same period. Reporting sensitivity was calculated as the ratio of the rates at which events were reported to each passive surveillance system (numerator) and occurred in controlled studies (denominator). Reporting sensitivities were generally better in the public sector than in the private sector. The significant underreporting of known outcomes, together with the nonspecific nature of most adverse event reports, highlights the limitations of passive surveillance systems in assessing the incidence of vaccine adverse events.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1013K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Stetler HC, Orenstein WA, Bart KJ, Brink EW, Brennan JP, Hinman AR. History of convulsions and use of pertussis vaccine. J Pediatr. 1985 Aug;107(2):175–179. [PubMed]
  • Chen RT, Haber P, Mullen JR. Surveillance of the safety of simultaneous administration of vaccines. The Centers for Disease Control and Prevention experience. Ann N Y Acad Sci. 1995 May 31;754:309–320. [PubMed]
  • Stetler HC, Mullen JR, Brennan JP, Livengood JR, Orenstein WA, Hinman AR. Monitoring system for adverse events following immunization. Vaccine. 1987 Sep;5(3):169–174. [PubMed]
  • Chen RT, Rastogi SC, Mullen JR, Hayes SW, Cochi SL, Donlon JA, Wassilak SG. The Vaccine Adverse Event Reporting System (VAERS). Vaccine. 1994 May;12(6):542–550. [PubMed]
  • Griffin MR, Ray WA, Mortimer EA, Fenichel GM, Schaffner W. Risk of seizures after measles-mumps-rubella immunization. Pediatrics. 1991 Nov;88(5):881–885. [PubMed]
  • Pollock TM, Morris J. A 7-year survey of disorders attributed to vaccination in North West Thames region. Lancet. 1983 Apr 2;1(8327):753–757. [PubMed]
  • Deforest A, Long SS, Lischner HW, Girone JA, Clark JL, Srinivasan R, Maguire TG, Diamond SA, Schiller RP, Rothstein EP, et al. Simultaneous administration of measles-mumps-rubella vaccine with booster doses of diphtheria-tetanus-pertussis and poliovirus vaccines. Pediatrics. 1988 Feb;81(2):237–246. [PubMed]
  • Nieminen U, Peltola H, Syrjälä MT, Mäkipernaa A, Kekomäki R. Acute thrombocytopenic purpura following measles, mumps and rubella vaccination. A report on 23 patients. Acta Paediatr. 1993 Mar;82(3):267–270. [PubMed]
  • Cody CL, Baraff LJ, Cherry JD, Marcy SM, Manclark CR. Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children. Pediatrics. 1981 Nov;68(5):650–660. [PubMed]
  • Pollock TM, Miller E, Mortimer JY, Smith G. Post-vaccination symptoms following DTP and DT vaccination. Dev Biol Stand. 1985;61:407–410. [PubMed]
  • Walker AM, Jick H, Perera DR, Thompson RS, Knauss TA. Diphtheria-tetanus-pertussis immunization and sudden infant death syndrome. Am J Public Health. 1987 Aug;77(8):945–951. [PMC free article] [PubMed]
  • Strebel PM, Sutter RW, Cochi SL, Biellik RJ, Brink EW, Kew OM, Pallansch MA, Orenstein WA, Hinman AR. Epidemiology of poliomyelitis in the United States one decade after the last reported case of indigenous wild virus-associated disease. Clin Infect Dis. 1992 Feb;14(2):568–579. [PubMed]
  • Fletcher AP. Spontaneous adverse drug reaction reporting vs event monitoring: a comparison. J R Soc Med. 1991 Jun;84(6):341–344. [PMC free article] [PubMed]
  • Sills JM, Tanner LA, Milstien JB. Food and Drug Administration monitoring of adverse drug reactions. Am J Hosp Pharm. 1986 Nov;43(11):2764–2770. [PubMed]
  • Sutter RW, Cochi SL. Pertussis hospitalizations and mortality in the United States, 1985-1988. Evaluation of the completeness of national reporting. JAMA. 1992 Jan 15;267(3):386–391. [PubMed]
  • Sutter RW, Cochi SL, Brink EW, Sirotkin BI. Assessment of vital statistics and surveillance data for monitoring tetanus mortality, United States, 1979-1984. Am J Epidemiol. 1990 Jan;131(1):132–142. [PubMed]
  • Cochi SL, Edmonds LE, Dyer K, Greaves WL, Marks JS, Rovira EZ, Preblud SR, Orenstein WA. Congenital rubella syndrome in the United States, 1970-1985. On the verge of elimination. Am J Epidemiol. 1989 Feb;129(2):349–361. [PubMed]
  • Scott HD, Thacher-Renshaw A, Rosenbaum SE, Waters WJ, Jr, Green M, Andrews LG, Faich GA. Physician reporting of adverse drug reactions. Results of the Rhode Island Adverse Drug Reaction Reporting Project. JAMA. 1990 Apr 4;263(13):1785–1788. [PubMed]

Articles from American Journal of Public Health are provided here courtesy of American Public Health Association

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...