pmc logo image
Logo of brmedjBMJ helping doctors make better decisionsSearchLatest content

Formats:

Br Med J. 1979 December 8; 2(6203): 1474–1476.
PMCID: PMC1597157
Resetting of osmoreceptor response as cause of hyponatraemia in acute idiopathic polyneuritis.
M D Penney, D Murphy, and G Walters
Abstract
In a patient with hyponatraemia associated with acute idiopathic polyneuritis plasma concentrations of antidiuretic hormone increased when hypertonic saline was infused intravenously, and urine osmolality rose concomitantly. A water load was excreted normally, while the plasma remained extremely hypo-osmolal. It is concluded that osmoregulation was functioning normally but was set abnormally low, possibly owing to a disturbance of the peripheral volume receptors.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (582K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • HIGGINS G, O'BRIEN JR, LEWIN W, TAYLOR WH. Metabolic disorders in head injury; survey of 76 consecutive cases. Lancet. 1954 Jan 9;266(6802):61–67. [PubMed]
  • CORT JH. Cerebral salt wasting. Lancet. 1954 Apr 10;266(6815):752–754. [PubMed]
  • GOLDBERG M, HANDLER JS. Hyponatremia and renal wasting of sodium in patients with malfunction of the central nervous system. N Engl J Med. 1960 Nov 24;263:1037–1043. [PubMed]
  • Joynt RJ, Afifi A, Harrison J. Hyponatremia in subarachnoid hemorrhage. Arch Neurol. 1965 Dec;13(6):633–638. [PubMed]
  • Lipschutz DE, Reiter JM. Acute intermittent porphyria with inappropriately elevated ADH secretion. JAMA. 1974 Nov 4;230(5):716–717. [PubMed]
  • Conger JD, McIntyre JA, Jacoby WJ., Jr Central pontine myelinolysis associated with inappropriate antidiuretic hormone secretion. Am J Med. 1969 Nov;47(5):813–817. [PubMed]
  • CARTER NW, RECTOR FC, Jr, SELDIN DW. Hyponatremia in cerebral disease resulting from the inappropriate secretion of antidiuretic hormone. N Engl J Med. 1961 Jan 12;264:67–72. [PubMed]
  • Haslett C, Douglas NJ. Inappropriate antidiuretic hormone secretion associated with neurohypophyseal choristoma. Br Med J. 1978 Dec 23;2(6154):1753–1753. [PubMed]
  • Posner JB, Ertel NH, Kossmann RJ, Scheinberg LC. Hyponatremia in acute polyneuropathy. Four cases with the syndrome of inappropriate secretion of antidiuretic hormone. Arch Neurol. 1967 Nov;17(5):530–541. [PubMed]
  • Asbury AK, Arnason BG, Adams RD. The inflammatory lesion in idiopathic polyneuritis. Its role in pathogenesis. Medicine (Baltimore). 1969 May;48(3):173–215. [PubMed]
  • Bartter FC, Schwartz WB. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1967 May;42(5):790–806. [PubMed]
  • Michelis MF, Fusco RD, Bragdon RW, Davis BB. Reset of osmoreceptors in association with normovolemic hyponatremia. Am J Med Sci. 1974 May;267(5):267–273. [PubMed]
  • DeFronzo RA, Goldberg M, Agus ZS. Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion. Ann Intern Med. 1976 May;84(5):538–542. [PubMed]
  • Robertson GL, Mahr EA, Athar S, Sinha T. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. J Clin Invest. 1973 Sep;52(9):2340–2352. [PubMed]
  • DE WARDENER HE, HERXHEIMER A. The effect of a high water intake on the kidney's ability to concentrate the urine in man. J Physiol. 1957 Nov 14;139(1):42–52. [PubMed]
  • Goetz KL, Bond GC, Smith WE. Effect of moderate hemorrhage in humans on plasma ADH and renin. Proc Soc Exp Biol Med. 1974 Jan;145(1):277–280. [PubMed]
  • Robertson GL, Shelton RL, Athar S. The osmoregulation of vasopressin. Kidney Int. 1976 Jul;10(1):25–37. [PubMed]
  • Robertson GL, Bhoopalam N, Zelkowitz LJ. Vincristine neurotoxicity and abnormal secretion of antidiuretic hormone. Arch Intern Med. 1973 Nov;132(5):717–720. [PubMed]