• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of brmedjBMJ helping doctors make better decisionsSearchLatest content
Br Med J. Dec 15, 1973; 4(5893): 643–646.
PMCID: PMC1587636

Interpretation of Serum Calcium in Patients with Abnormal Serum Proteins

Abstract

Two hundred consecutive specimens received in this laboratory for “liver function tests” showed a wide range of abnormal protein concentrations. Calcium concentration correlated closely with albumin (r = 0·867) but less closely with total protein (r = 0·682). A simple formula for adjusting calcium concentration was derived from the regression equation of calcium on albumin. Adjusted calcium = calcium - albumin + 4·0, where calcium is in mg/100 ml and albumin in g/100 ml.

Low calcium concentrations were found in 49 (24·5%) and raised concentrations in six (3%) of the 200 blood specimens taken for liver function tests. After adjustment, the 95% limits of the observed range were identical with the 95% limits of the normal range determined in this laboratory. Unlike adjustments based on total protein or specific gravity, the adjustment on albumin in 39 specimens which showed hypergammaglobulinaemia on electrophoresis gave normal calcium concentrations.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (783K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Cockel R, Kendall MJ, Becker JF, Hawkins CF. Serum biochemical values in rheumatoid disease. Ann Rheum Dis. 1971 Mar;30(2):166–170. [PMC free article] [PubMed]
  • Cook MG, Levell MJ, Payne RB. A method for deriving normal ranges from laboratory specimens applied to uric acid in males. J Clin Pathol. 1970 Dec;23(9):778–780. [PMC free article] [PubMed]
  • DENT CE. Some problems of hyperparathyroidism. Br Med J. 1962 Dec 1;2(5317):1419–1425. [PMC free article] [PubMed]
  • Dent CE, Watson L. The hydrocortisone test in primary and tertiary hyperparathyroidism. Lancet. 1968 Sep 21;2(7569):662–664. [PubMed]
  • FAWCETT JK, WYNN V. Effects of posture on plasma volume and some blood constituents. J Clin Pathol. 1960 Jul;13:304–310. [PMC free article] [PubMed]
  • Jones JH, Peters DK, Morgan DB, Coles GA, Mallick NP. Observations on calcium metabolism in the nephrotic syndrome. Q J Med. 1967 Jul;36(143):301–320. [PubMed]
  • Keating FR, Jr, Jones JD, Elveback LR, Randall RV. The relation of age and sex to distribution of values in healthy adults of serum calcium, inorganic phosphorus, magnesium, alkaline phosphatase, total proteins, albumin, and blood urea. J Lab Clin Med. 1969 May;73(5):825–834. [PubMed]
  • Orrell DH. Albumin as an aid to the interpretation of serum calcium. Clin Chim Acta. 1971 Dec;35(2):483–489. [PubMed]
  • Payne RB. Serum-albumin in Asians. Lancet. 1973 Aug 18;2(7825):375–375. [PubMed]
  • Pedersen KO. Determination of calcium fractions of serum. 3. Ionized calcium in ultrafiltrates of normal serum and examination of pertinent variables. Scand J Clin Lab Invest. 1970 May;25(3):223–230. [PubMed]
  • Pedersen KO. Protein-bound calcium in human serum. Quantitative examination of binding and its variables by a molecular binding model and clinical chemical implications for measurement of ionized calcium. Scand J Clin Lab Invest. 1972 Nov;30(3):321–329. [PubMed]
  • Rose GA. A simple and rapid method for the measurement of plasma ultrafiltrable and ionized calcium. Clin Chim Acta. 1972 Mar;37:343–349. [PubMed]
  • van LEEUWEN A, THOMASSE CM, KAPTEYN PC. The determination of protein-bound calcium and magnesium by ultrafiltration-in-vivo with special reference to terminology and method. Clin Chim Acta. 1961 Jul;6:550–565. [PubMed]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...