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Journal List > Clin Exp Immunol > v.3(3); Mar 1968

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Clin Exp Immunol. 1968 March; 3(3): 269–276.
PMCID: PMC1578887
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Timing of different virus neutralizing 19S and 7S antibodies in natural Coxsackie infections of newborn babies and adults
O. Mäkelä, Kaisa Lapinleimu, and Ella Kostiainen
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Abstract
Neutralizing Coxsackie antibodies arising from natural infections with Coxsackie virus type B3 or B5 were studied in adults and newborn babies. No differences could be found between the antibody response of the newborn babies and that of the adults.
The antibody titres rose approximately as rapidly in the babies as in the adult patients, and the means of the peak titres did not differ significantly in the two groups. Early in the infection the neutralizing antibodies of both newborn babies and adults were exclusively IgM. There was a gradual shift to IgG in the course of 3 months, and this shift was as rapid in babies as in adults.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Alford CA., Jr Studies on antibody in congenital rubella infections. I. Physicochemical and immunologic investigations of rubella neutralizing antibody. Am J Dis Child. 1965 Oct;110(4):455–463. [PubMed]
  • BRADFORD WL, DAY E, MARTIN F. Humoral antibody formation in infants aged 1 to 3 months injected with a triple (diphtheria-tetanus-pertussis) alum-precipitated antigen. Pediatrics. 1949 Dec;4(6):711–718. [PubMed]
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  • FLACK A, HUMMELER K, HUNT AD, Jr, JERVIS GA, KOPROWSKI H, NORTON TW, STOKES J., Jr Immunization of infants with living attenuated poliomyelitis virus; laboratory investigations of alimentary infection and antibody response in infants under six months of age with congenitally acquired antibodies. J Am Med Assoc. 1956 Dec 1;162(14):1281–1288. [PubMed]
  • Ohta-Hatano R, Hinuma Y. Mercaptoethanol-sensitive neutralizing-antibody in natural infection with coxsackievirus B5. Proc Soc Exp Biol Med. 1966 Jul;122(3):725–729. [PubMed]
  • OSBORN JJ, DANCIS J, JULIA JF. Studies of the immunology of the newborn infant. I. Age and antibody production. Pediatrics. 1952 Jun;9(6):736–744. [PubMed]
  • SMITH RT, EITZMAN DV. THE DEVELOPMENT OF THE IMMUNE RESPONSE. CHARACTERIZATION OF THE RESPONSE OF THE HUMAN INFANT AND ADULT TO IMMUNIZATION WITH SALMONELLA VACCINES. Pediatrics. 1964 Feb;33:163–183. [PubMed]
  • UHR JW, DANCIS J, FRANKLIN EC, FINKELSTEIN MS, LEWIS EW. The antibody response to bacteriophage phi-X 174 in newborn premature infants. J Clin Invest. 1962 Jul;41:1509–1513. [PubMed]
  • UHR JW, FINKELSTEIN MS. Antibody formation. IV. Formation of rapidly and slowly sedimenting antibodies and immunological memory to bacteriophage phi-X 174. J Exp Med. 1963 Mar 1;117:457–477. [PubMed]
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