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Journal List > Calif Med > v.92(2); Feb 1960

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Calif Med. 1960 February; 92(2): 155–158.
PMCID: PMC1577997
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INTRANASAL INJECTION OF CORTICOSTEROIDS
Marvin W. Simmons
Abstract
Intranasal injections into the inferior turbinates of a slightly form of prednisolone TBA (Hydeltra® TBA) into persons with complaint of nasal obstruction gave considerable relief in 78 per cent of cases. Nasal hyperfunction due to seasonal allergic rhinitis, vasomotor rhinitis and secondary nasal edema from sinusitis was the indication for use. No local or general reactions other than a small amount of bleeding at the time of injection was noted. This method allows full utilization of the anti-inflammatory activity of corticosteroids at the local tissue level without producing a systemic effect.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • BORDLEY JE, CAREY RA, et al. Preliminary observations on the effect of adrenocorticotropic hormone in allergic diseases. Bull Johns Hopkins Hosp. 1949 Nov;85(5):396–398. [PubMed]
  • BORDLEY JE. Observations on changes taking place in the upper respiratory tract of patients under ACTH and cortisone therapy. Bull Johns Hopkins Hosp. 1950 Nov;87(5):415–424. [PubMed]
  • BORDLEY JE. The effect of ACTH and cortisone on the upper respiratory tract. N Y State J Med. 1951 Nov 15;51(22):2636–2639. [PubMed]
  • DILL JL, BOLSTAD DS. Observations on the local use of cortisone in the nose in allergic rhinitis. Laryngoscope. 1951 May;61(5):415–422. [PubMed]
  • DILL JL, BOLSTAD DS. Further observations on the local use of cortisone in the nose in allergic rhinitis. Trans Am Acad Ophthalmol Otolaryngol. 1952 Mar–Apr;56(2):214–219. [PubMed]
  • EVANS WH. The use of a suspension of cortogen acetate with chlor-trimeton maleate in the treatment of allergic rhinitis of pollen origin. Trans Am Acad Ophthalmol Otolaryngol. 1954 Jan–Feb;58(1):89–103. [PubMed]
  • KOELSCHE GA, MAYTUM CK, PRICKMAN LE, CARRYER HM. Use of cortisone and ACTH in the management of nasal allergy. Ann Allergy. 1951 Sep–Oct;9(5):573–passim. [PubMed]
  • RAWLINS AG. The uses and abuses of the corticosteroids in ophthalmology and otolaryngology: otolaryngologic aspects. Trans Am Acad Ophthalmol Otolaryngol. 1956 Jul–Aug;60(4):509–518. [PubMed]
  • SEMENOV H. The pathology of the nose and paranasal sinuses in relation to allergy; with comments on the local injection of cortisone. Trans Am Acad Ophthalmol Otolaryngol. 1952 Mar–Apr;56(2):121–170. [PubMed]
  • SILCOX LE. The intranasal use of hydrocortisone alcohol. AMA Arch Otolaryngol. 1954 Oct;60(4):431–439. [PubMed]
  • STEWART JP, KAWA MZ. Further observations on the effect of cortisone and ACTH in the treatment of allergic rhinitis. J Laryngol Otol. 1954 Apr;68(4):193–210. [PubMed]
  • WALL JW, SHURE N. Intranasal cortisone; preliminary study. AMA Arch Otolaryngol. 1952 Aug;56(2):172–176. [PubMed]
  • WILLIAMS HL. The use of cortisone and corticotropin in the field of otorhinology and laryngology. Ann Otol Rhinol Laryngol. 1952 Jun;61(2):497–504. [PubMed]
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