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Environ Health Perspect. Dec 1994; 102(12): 1038–1050.
PMCID: PMC1567493
Research Article

Asbestos and colon cancer: a weight-of-the-evidence review.

Abstract

What is the evidence that exposure to asbestos causes colon cancer? This weight-of-evidence review considers epidemiologic evidence from cohort studies of asbestos-exposed workers, case-control studies of colon cancer, animal bioassays, and other corroborative evidence. The major evidence for a causal association at high exposure is a combined colorectal standardized mortality ratio (SMR) of 1.5 for asbestos cohorts where the lung cancer SMR was greater than twofold. However, misdiagnosis may spuriously elevate the SMR. The strongest evidence against a causal association between colon cancer and asbestos exposure is the lack of an exposure-response gradient in asbestos cohorts where trends for lung cancer are observed. Population-based case-control studies of colon cancer do not show any consistent risk associated with asbestos exposure. Long-term ingestion studies show no evidence of an increased incidence of colon cancer in animals by this route of exposure and do not provide biological plausibility for a causal association between asbestos exposure and colon cancer.

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  • Miller AB. Asbestos fibre dust and gastro-intestinal malignancies. Review of literature with regard to a cause/effect relationship. J Chronic Dis. 1978 Jan;31(1):23–33. [PubMed]
  • Levine DS. Does asbestos exposure cause gastrointestinal cancer? Dig Dis Sci. 1985 Dec;30(12):1189–1198. [PubMed]
  • Neugut AI, Wylie P. Occupational cancers of the gastrointestinal tract. I. Colon, stomach, and esophagus. Occup Med. 1987 Jan-Mar;2(1):109–135. [PubMed]
  • Edelman DA. Exposure to asbestos and the risk of gastrointestinal cancer: a reassessment. Br J Ind Med. 1988 Feb;45(2):75–82. [PMC free article] [PubMed]
  • Frumkin H, Berlin J. Asbestos exposure and gastrointestinal malignancy review and meta-analysis. Am J Ind Med. 1988;14(1):79–95. [PubMed]
  • HILL AB. THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION? Proc R Soc Med. 1965 May;58:295–300. [PMC free article] [PubMed]
  • Ashby J, Doerrer NG, Flamm FG, Harris JE, Hughes DH, Johannsen FR, Lewis SC, Krivanek ND, McCarthy JF, Moolenaar RJ, et al. A scheme for classifying carcinogens. Regul Toxicol Pharmacol. 1990 Dec;12(3 Pt 1):270–295. [PubMed]
  • Lew EA, Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis. 1979;32(8):563–576. [PubMed]
  • Nomura A, Heilbrun LK, Stemmermann GN. Body mass index as a predictor of cancer in men. J Natl Cancer Inst. 1985 Feb;74(2):319–323. [PubMed]
  • Spiegelman D, Wegman DH. Occupation-related risks for colorectal cancer. J Natl Cancer Inst. 1985 Nov;75(5):813–821. [PubMed]
  • Wu AH, Paganini-Hill A, Ross RK, Henderson BE. Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study. Br J Cancer. 1987 Jun;55(6):687–694. [PMC free article] [PubMed]
  • Klatsky AL, Armstrong MA, Friedman GD, Hiatt RA. The relations of alcoholic beverage use to colon and rectal cancer. Am J Epidemiol. 1988 Nov;128(5):1007–1015. [PubMed]
  • Gerhardsson M, Floderus B, Norell SE. Physical activity and colon cancer risk. Int J Epidemiol. 1988 Dec;17(4):743–746. [PubMed]
  • Slattery ML, Schumacher MC, Smith KR, West DW, Abd-Elghany N. Physical activity, diet, and risk of colon cancer in Utah. Am J Epidemiol. 1988 Nov;128(5):989–999. [PubMed]
  • Garabrant DH, Peters JM, Mack TM, Bernstein L. Job activity and colon cancer risk. Am J Epidemiol. 1984 Jun;119(6):1005–1014. [PubMed]
  • Vena JE, Graham S, Zielezny M, Swanson MK, Barnes RE, Nolan J. Lifetime occupational exercise and colon cancer. Am J Epidemiol. 1985 Sep;122(3):357–365. [PubMed]
  • Gerhardsson M, Norell SE, Kiviranta H, Pedersen NL, Ahlbom A. Sedentary jobs and colon cancer. Am J Epidemiol. 1986 May;123(5):775–780. [PubMed]
  • Fredriksson M, Bengtsson NO, Hardell L, Axelson O. Colon cancer, physical activity, and occupational exposures. A case-control study. Cancer. 1989 May 1;63(9):1838–1842. [PubMed]
  • Severson RK, Nomura AM, Grove JS, Stemmermann GN. A prospective analysis of physical activity and cancer. Am J Epidemiol. 1989 Sep;130(3):522–529. [PubMed]
  • Brownson RC, Zahm SH, Chang JC, Blair A. Occupational risk of colon cancer. An analysis by anatomic subsite. Am J Epidemiol. 1989 Oct;130(4):675–687. [PubMed]
  • Markowitz S, Morabia A, Garibaldi K, Wynder E. Effect of occupational and recreational activity on the risk of colorectal cancer among males: a case-control study. Int J Epidemiol. 1992 Dec;21(6):1057–1062. [PubMed]
  • Williams RR, Horm JW. Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey. J Natl Cancer Inst. 1977 Mar;58(3):525–547. [PubMed]
  • Pollack ES, Nomura AM, Heilbrun LK, Stemmermann GN, Green SB. Prospective study of alcohol consumption and cancer. N Engl J Med. 1984 Mar 8;310(10):617–621. [PubMed]
  • Potter JD, McMichael AJ. Diet and cancer of the colon and rectum: a case-control study. J Natl Cancer Inst. 1986 Apr;76(4):557–569. [PubMed]
  • La Vecchia C, Ferraroni M, Negri E, D'Avanzo B, Decarli A, Levi F, Franceschi S. Coffee consumption and digestive tract cancers. Cancer Res. 1989 Feb 15;49(4):1049–1051. [PubMed]
  • Newhouse ML, Wagner JC. Validation of death certificates in asbestos workers. Br J Ind Med. 1969 Oct;26(4):302–307. [PMC free article] [PubMed]
  • Selikoff IJ, Hammond EC, Seidman H. Mortality experience of insulation workers in the United States and Canada, 1943--1976. Ann N Y Acad Sci. 1979;330:91–116. [PubMed]
  • Percy C, Stanek E, 3rd, Gloeckler L. Accuracy of cancer death certificates and its effect on cancer mortality statistics. Am J Public Health. 1981 Mar;71(3):242–250. [PMC free article] [PubMed]
  • Hodgson JT, Jones RD. Mortality of asbestos workers in England and Wales 1971-81. Br J Ind Med. 1986 Mar;43(3):158–164. [PMC free article] [PubMed]
  • Melkild A, Langård S, Andersen A, Tønnessen JN. Incidence of cancer among welders and other workers in a Norwegian shipyard. Scand J Work Environ Health. 1989 Dec;15(6):387–394. [PubMed]
  • Enterline PE, Hartley J, Henderson V. Asbestos and cancer: a cohort followed up to death. Br J Ind Med. 1987 Jun;44(6):396–401. [PMC free article] [PubMed]
  • Kjuus H, Andersen A, Langård S, Knudsen KE. Cancer incidence among workers in the Norwegian ferroalloy industry. Br J Ind Med. 1986 Apr;43(4):227–236. [PMC free article] [PubMed]
  • Kjuus H, Andersen A, Langård S. Incidence of cancer among workers producing calcium carbide. Br J Ind Med. 1986 Apr;43(4):237–242. [PMC free article] [PubMed]
  • Raffn E, Lynge E, Juel K, Korsgaard B. Incidence of cancer and mortality among employees in the asbestos cement industry in Denmark. Br J Ind Med. 1989 Feb;46(2):90–96. [PMC free article] [PubMed]
  • Acheson ED, Gardner MJ, Winter PD, Bennett C. Cancer in a factory using amosite asbestos. Int J Epidemiol. 1984 Mar;13(1):3–10. [PubMed]
  • Liddell FD, Hanley JA. Relations between asbestos exposure and lung cancer SMRs in occupational cohort studies. Br J Ind Med. 1985 Jun;42(6):389–396. [PMC free article] [PubMed]
  • Ohlson CG, Klaesson B, Hogstedt C. Mortality among asbestos-exposed workers in a railroad workshop. Scand J Work Environ Health. 1984 Oct;10(5):283–291. [PubMed]
  • Hughes JM, Weill H, Hammad YY. Mortality of workers employed in two asbestos cement manufacturing plants. Br J Ind Med. 1987 Mar;44(3):161–174. [PMC free article] [PubMed]
  • McDonald JC, Liddell FD, Gibbs GW, Eyssen GE, McDonald AD. Dust exposure and mortality in chrysotile mining, 1910-75. Br J Ind Med. 1980 Feb;37(1):11–24. [PMC free article] [PubMed]
  • Peto J, Doll R, Hermon C, Binns W, Clayton R, Goffe T. Relationship of mortality to measures of environmental asbestos pollution in an asbestos textile factory. Ann Occup Hyg. 1985;29(3):305–355. [PubMed]
  • Woitowitz HJ, Lange HJ, Beierl L, Rathgeb M, Schmidt K, Ulm K, Giesen T, Woitowitz RH, Pache L, Rödelsperger K. Mortality rates in the Federal Republic of Germany following previous occupational exposure to asbestos dust. Int Arch Occup Environ Health. 1986;57(3):161–171. [PubMed]
  • Albin M, Jakobsson K, Attewell R, Johansson L, Welinder H. Mortality and cancer morbidity in cohorts of asbestos cement workers and referents. Br J Ind Med. 1990 Sep;47(9):602–610. [PMC free article] [PubMed]
  • Hilt B, Andersen A, Rosenberg J, Langård S. Cancer incidence among asbestos-exposed chemical industry workers: an extended observation period. Am J Ind Med. 1991;20(2):261–264. [PubMed]
  • Axelsson G, Rylander R, Schmidt A. Mortality and incidence of tumours among ferrochromium workers. Br J Ind Med. 1980 May;37(2):121–127. [PMC free article] [PubMed]
  • Seidman H, Selikoff IJ, Gelb SK. Mortality experience of amosite asbestos factory workers: dose-response relationships 5 to 40 years after onset of short-term work exposure. Am J Ind Med. 1986;10(5-6):479–514. [PubMed]
  • Jakobsson K, Attewell R, Hultgren B, Sjöland K. Gastrointestinal cancer among cement workers. A case-referent study. Int Arch Occup Environ Health. 1990;62(4):337–340. [PubMed]
  • Browne K. A threshold for asbestos related lung cancer. Br J Ind Med. 1986 Aug;43(8):556–558. [PMC free article] [PubMed]
  • Hardell L. Relation of soft-tissue sarcoma, malignant lymphoma and colon cancer to phenoxy acids, chlorophenols and other agents. Scand J Work Environ Health. 1981 Jun;7(2):119–130. [PubMed]
  • Gerhardsson de Verdier M, Plato N, Steineck G, Peters JM. Occupational exposures and cancer of the colon and rectum. Am J Ind Med. 1992;22(3):291–303. [PubMed]
  • Garabrant DH, Peters RK, Homa DM. Asbestos and colon cancer: lack of association in a large case-control study. Am J Epidemiol. 1992 Apr 15;135(8):843–853. [PubMed]
  • Condie LW. Review of published studies of orally administered asbestos. Environ Health Perspect. 1983 Nov;53:3–9. [PMC free article] [PubMed]
  • Donham KJ, Will LA, Denman D, Leininger JR. The combined effects of asbestos ingestion and localized X-irradiation of the colon in rats. J Environ Pathol Toxicol Oncol. 1984 Jul;5(4-5):299–308. [PubMed]
  • Ward JM, Frank AL, Wenk M, Devor D, Tarone RE. Ingested asbestos and intestinal carcinogenesis in F344 rats. J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):301–312. [PubMed]
  • McConnell EE, Rutter HA, Ulland BM, Moore JA. Chronic effects of dietary exposure to amosite asbestos and tremolite in F344 rats. Environ Health Perspect. 1983 Nov;53:27–44. [PMC free article] [PubMed]
  • McConnell EE, Shefner AM, Rust JH, Moore JA. Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters. Environ Health Perspect. 1983 Nov;53:11–25. [PMC free article] [PubMed]
  • Bolton RE, Davis JM, Lamb D. The pathological effects of prolonged asbestos ingestion in rats. Environ Res. 1982 Oct;29(1):134–150. [PubMed]
  • Davis JM, Bolton RE, Garrett J. Penetration of cells by asbestos fibers. Environ Health Perspect. 1974 Dec;9:255–260. [PMC free article] [PubMed]
  • Cook PM. Review of published studies on gut penetration by ingested asbestos fibers. Environ Health Perspect. 1983 Nov;53:121–130. [PMC free article] [PubMed]
  • Meek ME. Transmigration of ingested asbestos. Environ Health Perspect. 1983 Nov;53:149–152. [PMC free article] [PubMed]
  • Patel-Mandlik K, Millette J. Accumulation of ingested asbestos fibers in rat tissues over time. Environ Health Perspect. 1983 Nov;53:197–200. [PMC free article] [PubMed]
  • Mossman BT. In vitro approaches for determining mechanisms of toxicity and carcinogenicity by asbestos in the gastrointestinal and respiratory tracts. Environ Health Perspect. 1983 Nov;53:155–161. [PMC free article] [PubMed]
  • Amacher DE, Alarif A, Epstein SS. Effects of ingested chrysotile on DNA synthesis in the gastrointestinal tract and liver of the rat. Environ Health Perspect. 1974 Dec;9:319–324. [PMC free article] [PubMed]
  • Ehrlich A, Gordon RE, Dikman SH. Carcinoma of the colon in asbestos-exposed workers: analysis of asbestos content in colon tissue. Am J Ind Med. 1991;19(5):629–636. [PubMed]

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