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Environ Health Perspect. Mar 1993; 99: 195–197.
PMCID: PMC1567032
Research Article

Exposure to aflatoxin B1 in animal-feed production plant workers.

Abstract

The exposure to aflatoxin B1 (AFB) in animal-feed processing plants was assessed using binding of AFB to serum albumin. The albumin fraction was digested with pronase, and the digest was purified on a C18 Sepak column and an aflatest affinity column before quantification by ELISA. The level of detectability was 5 pg/mg albumin. The workers served as their own controls, as blood samples were taken upon return from vacation and after 4 weeks of work. A total of 7 of 45 samples were positive for AFB, with an estimated average daily intake of 64 ng AFB/kg body weight. The exposed workers had been disembarking cargos contaminated with AFB or working at places where the dust contained detectable amounts of AFB. The sera from the exposed workers had a significantly higher titer against an aflatoxin B1-epitope than a nonexposed Danish control group. The level of exposure could partly explain the increased risk of liver cancer in workers in the animal-feed processing industry.

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Selected References

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  • Hayes RB, van Nieuwenhuize JP, Raatgever JW, ten Kate FJ. Aflatoxin exposures in the industrial setting: an epidemiological study of mortality. Food Chem Toxicol. 1984 Jan;22(1):39–43. [PubMed]
  • McLaughlin JK, Malker HS, Malker BK, Stone BJ, Ericsson JL, Blot WJ, Weiner JA, Fraumeni JF., Jr Registry-based analysis of occupational risks for primary liver cancer in Sweden. Cancer Res. 1987 Jan 1;47(1):287–291. [PubMed]
  • Yoneda S, Fujisawa M, Watanabe J, Okabe T, Takaku F, Homma T, Yoshida K. Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody. Br J Cancer. 1988 Sep;58(3):292–295. [PMC free article] [PubMed]
  • Dragsted LO, Bull I, Autrup H. Substances with affinity to a monoclonal aflatoxin B1 antibody in Danish urine samples. Food Chem Toxicol. 1988 Mar;26(3):233–242. [PubMed]
  • Wild CP, Jiang YZ, Sabbioni G, Chapot B, Montesano R. Evaluation of methods for quantitation of aflatoxin-albumin adducts and their application to human exposure assessment. Cancer Res. 1990 Jan 15;50(2):245–251. [PubMed]
  • Sun ZT. [Monoclonal antibody against aflatoxin B1 and its potential application]. Zhonghua Zhong Liu Za Zhi. 1983 Nov;5(6):401–405. [PubMed]
  • van Rensburg SJ, van Schalkwyk GC, van Schalkwyk DJ. Primary liver cancer and aflatoxin intake in Transkei. J Environ Pathol Toxicol Oncol. 1990 Jan-Apr;10(1-2):11–16. [PubMed]
  • Autrup H, Seremet T, Wakhisi J. Evidence for human antibodies that recognize an aflatoxin epitope in groups with high and low exposure to aflatoxins. Arch Environ Health. 1990 Jan-Feb;45(1):31–34. [PubMed]
  • Silbart LK, Keren DF. Reduction of intestinal carcinogen absorption by carcinogen-specific secretory immunity. Science. 1989 Mar 17;243(4897):1462–1464. [PubMed]
  • Caviezel M, Aeschbach AP, Lutz WK, Schlatter C. Reduction of covalent binding of aflatoxin B1 to rabbit liver DNA after immunization against this carcinogen. Arch Toxicol Suppl. 1984;7:249–252. [PubMed]
  • Moolten FL, Schreiber B, Rizzone A, Weiss AJ, Boger E. Protection of mice against 7,12-dimethylbenz(a)anthracene-induced skin tumors by immunization with a fluorinated analog of the carcinogen. Cancer Res. 1981 Feb;41(2):425–429. [PubMed]
  • Pestka JJ, Bondy GS. Alteration of immune function following dietary mycotoxin exposure. Can J Physiol Pharmacol. 1990 Jul;68(7):1009–1016. [PubMed]

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