Logo of envhperEnvironmental Health PerspectivesBrowse ArticlesAbout EHPGeneral InformationAuthorsMediaProgramsPartnerships
Environ Health Perspect. Sep 1999; 107(9): 753–756.
PMCID: PMC1566443
Research Article

Tumor promoters in commercial indoor-plant cultivars of the Euphorbiaceae.

Abstract

Certain decorative indoor-plant cultivars are derived from toxic wild plant species. Native members of the Euphorbiaceae (spurge) contain highly irritating and tumor-promoting diterpene esters. Plant breeders and gardeners are constantly searching for less toxic cultivars of the popular Euphorbiaceae indoor plants. In this investigation, 22 commercial cultivars of Euphorbiaceae indoor plants were examined for tumor promoter contents by high-performance liquid chromatography (HPLC). Cultivars of E. milii (E. lomii hybrids), and in particular E. leuconeura, contained ingenol derivatives, whereas cultivars of E. pulcherrima and Codiaeum variegatum were devoid of these compounds. Tumor-promoting activity was assessed by induction of a luciferase reporter gene, which was placed under the control of an Epstein-Barr virus early antigen promoter. The response was closely correlated with ingenol ester content; the latex of the two E. leuconeura cultivars tested gave the strongest response. The HPLC and bioassay methods used in this study provide a basis for the development of nontoxic indoor-plant cultivars and perhaps for consumer-oriented labeling.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.8M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Giese M, Bauer-Doranth U, Langebartels C, Sandermann H., Jr Detoxification of Formaldehyde by the Spider Plant (Chlorophytum comosum L.) and by Soybean (Glycine max L.) Cell-Suspension Cultures. Plant Physiol. 1994 Apr;104(4):1301–1309. [PMC free article] [PubMed]
  • Wippermann U, Fliegmann J, Bauw G, Langebartels C, Maier K, Sandermann H., Jr Maize glutathione-dependent formaldehyde dehydrogenase: protein sequence and catalytic properties. Planta. 1999 Mar;208(1):12–18. [PubMed]
  • Hecker E. Co-carcinogene oder bedingt krebsauslösende Faktoren. Aktuelle neue Aspekte der Atiologie menschlicher Tumoren und des molekularen Mechanismus der Krebsentstehung. Naturwissenschaften. 1978 Dec;65(12):640–648. [PubMed]
  • Evans FJ, Soper CJ. The tigliane, daphnane and ingenane diterpenes, their chemistry, distribution and biological activities. A review. Lloydia. 1978 May-Jun;41(3):193–233. [PubMed]
  • Polack A, Laux G, Hergenhahn M, Kloz U, Roeser H, Hecker E, Bornkamm GW. Short-term assays for detection of conditional cancerogens. I. Construction of DR-CAT Raji cells and some of their characteristics as tester cells. Int J Cancer. 1992 Feb 20;50(4):611–616. [PubMed]
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976 May 7;72:248–254. [PubMed]
  • Vogg G, Mattes E, Rothenburger J, Hertkorn N, Achatz S, Sandermann H., Jr Tumor promoting diterpenes from Euphorbia leuconeura L. Phytochemistry. 1999 May;51(2):289–295. [PubMed]
  • Kinghorn AD, Evans FJ. A biological screen of selected species of the genus Euphorbia for skin irritant effects. Planta Med. 1975 Dec;28(4):326–335. [PubMed]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Science

Formats:

Related citations in PubMed

See reviews...See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...