• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of brjpharmLink to Publisher's site
Br J Pharmacol. Nov 13, 1997; 122(6): 1075–1082.
PMCID: PMC1565051

Calcium mobilization in Jurkat cells via A2b adenosine receptors

Abstract

  1. A functional study of cell surface A2b adenosine receptors was performed on the T cell leukaemia line, Jurkat.
  2. A2b receptors were coupled both to the adenylate cyclase system and to intracellular calcium channels. In fact, the agonist of A2b receptors, 5′-N-ethylcarboxamidoadenosine (NECA), led to a transient accumulation of intracellular calcium by an inositol phosphate-independent mechanism.
  3. The NECA-induced accumulation of cGMP was not responsible for the calcium mobilization via A2b receptors.
  4. The calcium response elicited by activation of A2b receptors was independent of that evoked by activation of the T cell receptor.
  5. These findings not only delineate a novel transduction mechanism for adenosine but also support a specific role for adenosine in modulating signals elicited via the T cell receptor.
Keywords: A2b adenosine receptors, calcium, calcium channels, cGMP, Jurkat cells, T lymphocytes, T cell receptor

Full Text

The Full Text of this article is available as a PDF (379K).

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...