Logo of clinexpimmunolLink to Publisher's site
Clin Exp Immunol. Oct 1992; 90(1): 31–35.
PMCID: PMC1554537

The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response.

Abstract

Two ELISAs for estimating mannan-binding protein (MBP) were constructed and the concentration of MBP in plasma was followed in patients undergoing major surgery and in patients having a malarial attack. In both cases increases of MBP in the plasma were observed. The relative increase and the kinetics varied from person to person. The concentration of MBP increased between 1.5- and three-fold following surgery. In some patients an increase was seen at day 1 whereas in others the increase was not observed until days 3-9. In the malaria patients an increased level of MBP was maintained during 30 days of treatment with chloroquine. The relative increase in MBP was independent of the presurgery or premalaria levels.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (997K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kawasaki T, Etoh R, Yamashina I. Isolation and characterization of a mannan-binding protein from rabbit liver. Biochem Biophys Res Commun. 1978 Apr 14;81(3):1018–1024. [PubMed]
  • Lu JH, Thiel S, Wiedemann H, Timpl R, Reid KB. Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex, of the classical pathway of complement, without involvement of C1q. J Immunol. 1990 Mar 15;144(6):2287–2294. [PubMed]
  • Soothill JF, Harvey BA. Defective opsonization. A common immunity deficiency. Arch Dis Child. 1976 Feb;51(2):91–99. [PMC free article] [PubMed]
  • Candy DC, Larcher VF, Tripp JH, Harries JT, Harvey BA, Soothill JF. Yeast opsonisation in children with chronic diarrhoeal states. Arch Dis Child. 1980 Mar;55(3):189–193. [PMC free article] [PubMed]
  • Richardson VF, Larcher VF, Price JF. A common congenital immunodeficiency predisposing to infection and atopy in infancy. Arch Dis Child. 1983 Oct;58(10):799–802. [PMC free article] [PubMed]
  • Levinsky RJ, Harvey BA, Paleja S. A rapid objective method for measuring the yeast opsonisation activity of serum. J Immunol Methods. 1978;24(3-4):251–256. [PubMed]
  • Turner MW, Mowbray JF, Roberton DR. A study of C3b deposition on yeast surfaces by sera of known opsonic potential. Clin Exp Immunol. 1981 Nov;46(2):412–419. [PMC free article] [PubMed]
  • Super M, Thiel S, Lu J, Levinsky RJ, Turner MW. Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet. 1989 Nov 25;2(8674):1236–1239. [PubMed]
  • Super M, Levinsky RJ, Turner MW. The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrations. Clin Exp Immunol. 1990 Feb;79(2):144–150. [PMC free article] [PubMed]
  • Kuhlman M, Joiner K, Ezekowitz RA. The human mannose-binding protein functions as an opsonin. J Exp Med. 1989 May 1;169(5):1733–1745. [PMC free article] [PubMed]
  • Malhotra R, Thiel S, Reid KB, Sim RB. Human leukocyte C1q receptor binds other soluble proteins with collagen domains. J Exp Med. 1990 Sep 1;172(3):955–959. [PMC free article] [PubMed]
  • Taylor ME, Brickell PM, Craig RK, Summerfield JA. Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein. Biochem J. 1989 Sep 15;262(3):763–771. [PMC free article] [PubMed]
  • Sastry K, Herman GA, Day L, Deignan E, Bruns G, Morton CC, Ezekowitz RA. The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. J Exp Med. 1989 Oct 1;170(4):1175–1189. [PMC free article] [PubMed]
  • Woo P, Korenberg JR, Whitehead AS. Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component. J Biol Chem. 1985 Oct 25;260(24):13384–13388. [PubMed]
  • Sastry K, Zahedi K, Lelias JM, Whitehead AS, Ezekowitz RA. Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692–697. [PubMed]
  • Ezekowitz RA, Day LE, Herman GA. A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins. J Exp Med. 1988 Mar 1;167(3):1034–1046. [PMC free article] [PubMed]
  • Nakajima T, Ballou CE. Characterization of the carbohydrate fragments obtained from Saccharomyces cerevisiae mannan by alkaline degradation. J Biol Chem. 1974 Dec 10;249(23):7679–7684. [PubMed]
  • Guesdon JL, Ternynck T, Avrameas S. The use of avidin-biotin interaction in immunoenzymatic techniques. J Histochem Cytochem. 1979 Aug;27(8):1131–1139. [PubMed]
  • Moeremans M, Daneels G, De Mey J. Sensitive colloidal metal (gold or silver) staining of protein blots on nitrocellulose membranes. Anal Biochem. 1985 Mar;145(2):315–321. [PubMed]
  • Kawasaki T, Kawasaki N, Yamashina I. Mannose/N-acetylglucosamine-binding proteins from mammalian sera. Methods Enzymol. 1989;179:310–321. [PubMed]
  • Townsend R, Stahl P. Isolation and characterization of a mannose/N-acetylglucosamine/fucose-binding protein from rat liver. Biochem J. 1981 Jan 15;194(1):209–214. [PMC free article] [PubMed]
  • Mizuno Y, Kozutsumi Y, Kawasaki T, Yamashina I. Isolation and characterization of a mannan-binding protein from rat liver. J Biol Chem. 1981 May 10;256(9):4247–4252. [PubMed]
  • Childs RA, Drickamer K, Kawasaki T, Thiel S, Mizuochi T, Feizi T. Neoglycolipids as probes of oligosaccharide recognition by recombinant and natural mannose-binding proteins of the rat and man. Biochem J. 1989 Aug 15;262(1):131–138. [PMC free article] [PubMed]
  • Eriksson B, Hellgren U, Rombo L. Changes in erythrocyte sedimentation rate, C-reactive protein and hematological parameters in patients with acute malaria. Scand J Infect Dis. 1989;21(4):434–441. [PubMed]
  • Sumiya M, Super M, Tabona P, Levinsky RJ, Arai T, Turner MW, Summerfield JA. Molecular basis of opsonic defect in immunodeficient children. Lancet. 1991 Jun 29;337(8757):1569–1570. [PubMed]
  • Pepys MB, Baltz ML. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv Immunol. 1983;34:141–212. [PubMed]
  • Thiel S, Reid KB. Structures and functions associated with the group of mammalian lectins containing collagen-like sequences. FEBS Lett. 1989 Jun 19;250(1):78–84. [PubMed]
  • Kawasaki N, Kawasaki T, Yamashina I. A serum lectin (mannan-binding protein) has complement-dependent bactericidal activity. J Biochem. 1989 Sep;106(3):483–489. [PubMed]
  • Ezekowitz RA, Kuhlman M, Groopman JE, Byrn RA. A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus. J Exp Med. 1989 Jan 1;169(1):185–196. [PMC free article] [PubMed]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...