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Journal List > Gut > v.11(10); Oct 1970

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Gut. 1970 October; 11(10): 843–846.
PMCID: PMC1553149
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Pepsin secretion in man after Histalog stimulation 1
Michael D. Turner, Paula J. Mayer, Leon L. Miller, and Harry L. Segal
1Supported by grants CA-09546 from the National Cancer Institute and 5-TO1-AM 5177 from the National Institute of Arthritis and Metabolic Diseases, United States Public Health Service.
Abstract
Human gastric juice shows three separable pepsin fractions on chromatography on DEAE-cellulose. The response of these fractions to stimulation with β-aminoethylpyrazole hydrochloride (Histalog) was studied. After a single intramuscular injection of Histalog (1·7 mg/kg body weight) there was an increase in the output of all three chromatographically distinguishable pepsin fractions. Little change was observed in the relative proportions of these three fractions and there was no evidence of selective stimulation of any individual fraction.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Chiang L, Sanchez-Chiang L, Wolf S, Tang J. The separate determination of human pepsin and gastricsin. Proc Soc Exp Biol Med. 1966 Jul;122(3):700–704. [PubMed]
  • SEIJFFERS MJ, SEGAL HL, MILLER LL. SEPARATION OF PEPSIN I, PEPSIN II A, PEPSIN II B, AND PEPSIN III FROM HUMAN GASTRIC MUCOSA. Am J Physiol. 1963 Dec;205:1099–1105. [PubMed]
  • SEIJFFERS MJ, SEGAL HL, MILLER LL. CHROMATOGRAPHIC SEPARATION OF PEPSINS FROM HUMAN GASTRIC JUICE. Am J Physiol. 1964 Jul;207:8–12. [PubMed]
  • Turner MD, Mangla JC, Samloff IM, Miller LL, Segal HL. Studies on the heterogeneity of human gastric zymogens. Biochem J. 1970 Feb;116(3):397–404. [PubMed]
  • Turner MD, Tuxill JL, Miller LL, Segal HL. Measurement of pepsin I (gastricsin) in human gastric juice. Gastroenterology. 1967 Dec;53(6):905–911. [PubMed]
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