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Br Med J (Clin Res Ed). 1983 July 2; 287(6384): 12–14. | PMCID: PMC1548155 |
Effect of daily oral omeprazole on 24 hour intragastric acidity. R P Walt, M D Gomes, E C Wood, L H Logan, and R E Pounder Abstract Twenty four hour intragastric acidity was measured in nine patients with duodenal ulcer before and after one week of treatment with oral omeprazole 30 mg daily, a drug that inhibits gastric secretion by inhibition of parietal cell H+K+ adenosinetriphosphatase (ATPase). Omeprazole virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001). This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1 g daily or ranitidine 300 mg daily. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (590K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Olbe L, Haglund U, Leth R, Lind T, Cederberg C, Ekenved G, Elander B, Fellenius E, Lundborg P, Wallmark B. Effects of substituted benzimidazole (H 149/94) on gastric acid secretion in humans. Gastroenterology. 1982 Jul;83(1 Pt 2):193–198. [PubMed]
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