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Journal List > Arch Dis Child > v.50(11); Nov 1975

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Arch Dis Child. 1975 November; 50(11): 896–899.
PMCID: PMC1545737
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Watery diarrhoea and ganglioneuroma with secretion of vasoactive intestinal peptide.
P G Swift, S R Bloom, and F Harris
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Abstract
A young girl presenting with diarrhoea and stridor was found to have a thoracic ganglioneuroma. The tumour, which was partially resected, contained an abnormally high amount of vasoactive intestinal peptide (VIP) as measured by radioimmunoassay. This decreased after the operation. In addition, analysis of urine showed the presence of abnormal amounts of catecholamines and catechol metabolites. The findings suggest that the diarrhoea in the syndrome of ganglioneuroma and bowel dysfunction is due to an excess of VIP secreted by the tumour.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Bloom SR, Polak JM, Pearse AG. Vasoactive intestinal peptide and watery-diarrhoea syndrome. Lancet. 1973 Jul 7;2(7819):14–16. [PubMed]
  • Hamilton JR, Radde IC, Johnson G. Diarrhea associated with adrenal ganglioneuroma. New findings related to the pathogenesis of diarrhea. Am J Med. 1968 Mar;44(3):453–463. [PubMed]
  • ROSENSTEIN BJ, ENGELMAN K. DIARRHEA IN A CHILD WITH A CATECHOLAMINE-SECRETING GANGLIONEUROMA. CASE REPORT AND REVIEW OF THE LITERATUTE. J Pediatr. 1963 Aug;63:217–226. [PubMed]
  • Sandler M, Karim SM, Williams ED. Prostaglandins in amine-peptide-secreting tumours. Lancet. 1968 Nov 16;2(7577):1053–1054. [PubMed]
  • STICKLER GB, HALLENBECK GA, FLOCK EV, ROSEVEAR JW. Catecholamines and diarrhea in ganglioneuroblastoma. Am J Dis Child. 1962 Dec;104:598–604. [PubMed]
  • VERNER JV, MORRISON AB. Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. Am J Med. 1958 Sep;25(3):374–380. [PubMed]
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