Figure 2
Body weight changes of Gulo −/− mice. (A) Females from a single litter from a heterozygous pair weaned on regular chow at age 21 days. Mean weights ± SD of one wild type plus three heterozygotes (●) and
of three homozygotes (○) are shown. At day 45, vitamin C (330 mg/liter) in the drinking water was given to the animals (stippled circle). Because one homozygote died at day 47, the values at days 51 and54 are the average weights of two homozygotes. Differences between two groups were statistically significant at all time points. (B) Nine Gulo −/− males were raised on chow with vitamin C supplementation to 8 weeks of age andthen supplementation was withdrawn from six of the mice. Mean body weights ± SD for three mice with vitamin C supplementation (stippled square) andfor six mice without supplementation (□) are shown, except that the 14th week was for three mice. P < 0.01 at 13-week time point.
of three homozygotes (○) are shown. At day 45, vitamin C (330 mg/liter) in the drinking water was given to the animals (stippled circle). Because one homozygote died at day 47, the values at days 51 and54 are the average weights of two homozygotes. Differences between two groups were statistically significant at all time points. (B) Nine Gulo −/− males were raised on chow with vitamin C supplementation to 8 weeks of age andthen supplementation was withdrawn from six of the mice. Mean body weights ± SD for three mice with vitamin C supplementation (stippled square) andfor six mice without supplementation (□) are shown, except that the 14th week was for three mice. P < 0.01 at 13-week time point.