• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of clinexpimmunolLink to Publisher's site
Clin Exp Immunol. May 1988; 72(2): 288–292.
PMCID: PMC1541533

The influence of the normal microbial flora on the susceptibility of rats to experimental autoimmune thyroiditis.

Abstract

Female PVG/c strain rats maintained under specific pathogen-free conditions until weaning were found to be significantly less susceptible to the induction of autoimmune thyroiditis by thymectomy and irradiation than conventionally reared rats of the same strain. Other SPF-derived strains had a similarly low susceptibility, thus pointing to an important external factor influencing the induction of autoimmunity by this procedure. It was found that the oral administration of antibiotics followed by fresh, homogenized, intestinal contents obtained from conventionally reared rats to newly weaned SPF PVG/c rats significantly augmented their autoimmune susceptibility. The offspring of female SPF rats which had been treated in late pregnancy with oral antibiotics and conventional intestinal contents were similarly more susceptible than the offspring of non-treated counterparts. It is proposed that the composition of the normal gastrointestinal flora of conventionally reared rats profoundly influences susceptibility to the induction of autoimmune thyroiditis in this particular experimental model, possibly by antigenic cross-reactivity with thyroid tissue.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (919K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ebringer A. Ankylosing spondylitis, immune-response-genes and molecular mimicry. Lancet. 1979 Jun 2;1(8127):1186–1186. [PubMed]
  • Esquivel PS, Rose NR, Kong YC. Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide. J Exp Med. 1977 May 1;145(5):1250–1263. [PMC free article] [PubMed]
  • Geczy AF, Alexander K, Bashir HV, Edmonds JP, Upfold L, Sullivan J. HLA-B27, Klebsiella and ankylosing spondylitis: biological and chemical studies. Immunol Rev. 1983;70:23–50. [PubMed]
  • Izui S, Eisenberg RA, Dixon FJ. IgM rheumatoid factors in mice injected with bacterial lipopolysaccharides. J Immunol. 1979 May;122(5):2096–2102. [PubMed]
  • KAPLAN MH, MEYESERIAN M. An immunological cross-reaction between group-A streptococcal cells and human heart tissue. Lancet. 1962 Apr 7;1(7232):706–710. [PubMed]
  • LeRoith D, Shiloach J, Roth J, Lesniak MA. Insulin or a closely related molecule is native to Escherichia coli. J Biol Chem. 1981 Jul 10;256(13):6533–6536. [PubMed]
  • Lidman K, Eriksson U, Norberg R, Fagraeus A. Indirect immunofluorescence staining of human thyroid by antibodies occurring in Yersinia enterocolitica infections. Clin Exp Immunol. 1976 Mar;23(3):429–435. [PMC free article] [PubMed]
  • Mackowiak PA. The normal microbial flora. N Engl J Med. 1982 Jul 8;307(2):83–93. [PubMed]
  • Maruo T, Cohen H, Segal SJ, Koide SS. Production of choriogonadotropin-like factor by a microorganism. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6622–6626. [PMC free article] [PubMed]
  • Penhale WJ, Farmer A, McKenna RP, Irvine WJ. Spontaneous thyroiditis in thymectomized and irradiated Wistar rats. Clin Exp Immunol. 1973 Oct;15(2):225–236. [PMC free article] [PubMed]
  • Penhale WJ, Irvine WJ, Inglis JR, Farmer A. Thyroiditis in T cell-depleted rats: suppression of the autoallergic response by reconstitution with normal lymphoid cells. Clin Exp Immunol. 1976 Jul;25(1):6–16. [PMC free article] [PubMed]
  • Shoenfeld Y, Rauch J, Massicotte H, Datta SK, André-Schwartz J, Stollar BD, Schwartz RS. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N Engl J Med. 1983 Feb 24;308(8):414–420. [PubMed]
  • Shenkman L, Bottone EJ. Antibodies to Yersinia enterocolitica in thyroid disease. Ann Intern Med. 1976 Dec;85(6):735–739. [PubMed]
  • Springer GF. Blood-group and Forssman antigenic determinants shared between microbes and mammalian cells. Prog Allergy. 1971;15:9–77. [PubMed]
  • Stefansson K, Dieperink ME, Richman DP, Gomez CM, Marton LS. Sharing of antigenic determinants between the nicotinic acetylcholine receptor and proteins in Escherichia coli, Proteus vulgaris, and Klebsiella pneumoniae. Possible role in the pathogenesis of myasthenia gravis. N Engl J Med. 1985 Jan 24;312(4):221–225. [PubMed]
  • van der Waaij D, Vossen JM, Altes CK, Hartgrink C. Reconventionalization following antibiotic decontamination in man and animals. Am J Clin Nutr. 1977 Nov;30(11):1887–1895. [PubMed]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...