• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of canvetjReference to the Publisher site.Journal Web siteJournal Web siteHow to Submit
Can Vet J. Sep 1998; 39(9): 559–565.
PMCID: PMC1539434

Salmonella typhimurium DT104: a virulent and drug-resistant pathogen.

Abstract

Salmonella typhimurium phage type (PT) or definitive type (DT) 104 is a virulent pathogen for humans and animals, particularly cattle. It has been isolated increasingly from humans and animals in the United Kingdom and several other European countries and, more recently, in the United States and Canada. Humans may acquire the infection from foods of animal origin contaminated with the infective organism. Farm families are particularly at risk of acquiring the infection by contact with infected animals or by drinking unpasteurized milk. The symptoms in cattle are watery to bloody diarrhea, a drop in milk production, pyrexia, anorexia, dehydration and depression. Infection may result in septicemic salmonellosis and, upon necropsy, a fibrinonecrotic enterocolitis may be observed. The infection occurs more commonly in the calving season than at other times. Feedlot cattle and pigs may also be affected. Prolonged carriage and shedding of the pathogen may occur. Symptoms in humans consist of diarrhea, fever, headache, nausea, abdominal pain, vomiting, and, less frequently, blood in the stool. Salmonella typhimurium DT104 strains are commonly resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.4M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Brisabois A, Cazin I, Breuil J, Collatz E. Surveillance of antibiotic resistance in Salmonella. Euro Surveill. 1997 Mar;2(3):19–20. [PubMed]
  • Glynn MK, Bopp C, Dewitt W, Dabney P, Mokhtar M, Angulo FJ. Emergence of multidrug-resistant Salmonella enterica serotype typhimurium DT104 infections in the United States. N Engl J Med. 1998 May 7;338(19):1333–1338. [PubMed]
  • Fone DL, Barker RM. Associations between human and farm animal infections with Salmonella typhimurium DT104 in Herefordshire. Commun Dis Rep CDR Rev. 1994 Oct 14;4(11):R136–R140. [PubMed]
  • Wall PG, Morgan D, Lamden K, Ryan M, Griffin M, Threlfall EJ, Ward LR, Rowe B. A case control study of infection with an epidemic strain of multiresistant Salmonella typhimurium DT104 in England and Wales. Commun Dis Rep CDR Rev. 1994 Oct 14;4(11):R130–R135. [PubMed]
  • Wall PG, Morgan D, Lamden K, Griffin M, Threlfall EJ, Ward LR, Rowe B. Transmission of multi-resistant strains of Salmonella typhimurium from cattle to man. Vet Rec. 1995 Jun 10;136(23):591–592. [PubMed]
  • Davies A, O'Neill P, Towers L, Cooke M. An outbreak of Salmonella typhimurium DT104 food poisoning associated with eating beef. Commun Dis Rep CDR Rev. 1996 Oct 11;6(11):R159–R162. [PubMed]
  • Wall PG, Threllfall EJ, Ward LR, Rowe B. Multiresistant Salmonella typhimurium DT104 in cats: a public health risk. Lancet. 1996 Aug 17;348(9025):471–471. [PubMed]
  • Sharp MW, Rawson BC. Persistent Salmonella typhimurium PT 104 infection in a dairy herd. Vet Rec. 1992 Oct 17;131(16):375–376. [PubMed]
  • West AM, Martin SW, McEwen SA, Clarke RC, Tamblyn SE. Factors associated with the presence of Salmonella spp. in dairy farm families in southwestern Ontario. Can J Public Health. 1988 Mar-Apr;79(2):119–123. [PubMed]
  • Low JC, Hopkins G, King T, Munro D. Antibiotic resistant Salmonella typhimurium DT104 in cattle. Vet Rec. 1996 Jun 29;138(26):650–651. [PubMed]
  • Penny CD, Low JC, Nettleton PF, Scott PR, Sargison ND, Strachan WD, Honeyman PC. Concurrent bovine viral diarrhoea virus and Salmonella typhimurium DT104 infection in a group of pregnant dairy heifers. Vet Rec. 1996 May 18;138(20):485–489. [PubMed]
  • Wall PG, Davis S, Threlfall EJ, Ward LR, Ewbank AJ. Chronic carriage of multidrug resistant Salmonella typhimurium in a cat. J Small Anim Pract. 1995 Jun;36(6):279–281. [PubMed]
  • Frost JA, Ward LR, Rowe B. Acquisition of a drug resistance plasmid converts Salmonella enteritidis phage type 4 to phage type 24. Epidemiol Infect. 1989 Oct;103(2):243–248. [PMC free article] [PubMed]
  • Rodrigue DC, Cameron DN, Puhr ND, Brenner FW, St Louis ME, Wachsmuth IK, Tauxe RV. Comparison of plasmid profiles, phage types, and antimicrobial resistance patterns of Salmonella enteritidis isolates in the United States. J Clin Microbiol. 1992 Apr;30(4):854–857. [PMC free article] [PubMed]
  • Threlfall EJ, Brown DJ, Rowe B, Ward LR. Occurrence of S typhimurium DT204c in poultry in England and Wales. Vet Rec. 1990 Sep 1;127(9):234–234. [PubMed]
  • Threlfall EJ, Frost JA, Ward LR, Rowe B. Epidemic in cattle and humans of Salmonella typhimurium DT 104 with chromosomally integrated multiple drug resistance. Vet Rec. 1994 May 28;134(22):577–577. [PubMed]
  • Threlfall EJ, Ward LR, Rowe B. Increasing incidence of resistance to trimethoprim and ciprofloxacin in epidemic Salmonella typhimurium DT104 in England and Wales. Euro Surveill. 1997 Nov;2(11):81–84. [PubMed]
  • Threlfall EJ, Frost JA, Ward LR, Rowe B. Increasing spectrum of resistance in multiresistant Salmonella typhimurium. Lancet. 1996 Apr 13;347(9007):1053–1054. [PubMed]
  • Besser TE, Gay CC, Gay JM, Hancock DD, Rice D, Pritchett LC, Erickson ED. Salmonellosis associated with S typhimurium DT104 in the USA. Vet Rec. 1997 Jan 18;140(3):75–75. [PubMed]
  • Low JC, Angus M, Hopkins G, Munro D, Rankin SC. Antimicrobial resistance of Salmonella enterica typhimurium DT104 isolates and investigation of strains with transferable apramycin resistance. Epidemiol Infect. 1997 Apr;118(2):97–103. [PMC free article] [PubMed]
  • Evans S, Davies R. Case control study of multiple-resistant Salmonella typhimurium DT104 infection of cattle in Great Britain. Vet Rec. 1996 Dec 7;139(23):557–558. [PubMed]
  • Low JC, Tennant B, Munro D. Multiple-resistant Salmonella typhimurium DT104 in cats. Lancet. 1996 Nov 16;348(9038):1391–1391. [PubMed]
  • Sandvang D, Aarestrup FM, Jensen LB. Characterisation of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhimurium DT104. FEMS Microbiol Lett. 1998 Mar 1;160(1):37–41. [PubMed]
  • Threlfall EJ, Hampton MD, Schofield SL, Ward LR, Frost JA, Rowe B. Epidemiological application of differentiating multiresistant Salmonella typhimurium DT104 by plasmid profile. Commun Dis Rep CDR Rev. 1996 Oct 11;6(11):R155–R159. [PubMed]
  • Hollingsworth J, Kaplan B. Federal agencies collaborate to control dangerous new Salmonella strain. J Am Vet Med Assoc. 1997 Jun 15;210(12):1712–1716. [PubMed]
  • Ryan CA, Nickels MK, Hargrett-Bean NT, Potter ME, Endo T, Mayer L, Langkop CW, Gibson C, McDonald RC, Kenney RT, et al. Massive outbreak of antimicrobial-resistant salmonellosis traced to pasteurized milk. JAMA. 1987 Dec 11;258(22):3269–3274. [PubMed]
  • Bezanson GS, Khakhria R, Duck D, Lior H. Molecular analysis confirms food source and simultaneous involvement of two distinct but related subgroups of Salmonella typhimurium bacteriophage type 10 in major interprovincial Salmonella outbreak. Appl Environ Microbiol. 1985 Nov;50(5):1279–1284. [PMC free article] [PubMed]
  • Rowe B, Ward LR, Threlfall EJ. Ciprofloxacin and typhoid fever. Lancet. 1992 Mar 21;339(8795):740–740. [PubMed]
  • Wain J, Hoa NT, Chinh NT, Vinh H, Everett MJ, Diep TS, Day NP, Solomon T, White NJ, Piddock LJ, et al. Quinolone-resistant Salmonella typhi in Viet Nam: molecular basis of resistance and clinical response to treatment. Clin Infect Dis. 1997 Dec;25(6):1404–1410. [PubMed]
  • Wray C, McLaren I, Wise R, Piddock LJ. Nalidixic acid-resistant salmonellae. Vet Rec. 1990 May 12;126(19):489–489. [PubMed]
  • Griggs DJ, Hall MC, Jin YF, Piddock LJ. Quinolone resistance in veterinary isolates of Salmonella. J Antimicrob Chemother. 1994 Jun;33(6):1173–1189. [PubMed]
  • Smith BP, Habasha FG, Reina-Guierra M, Hardy AJ. Immunization of calves against salmonellosis. Am J Vet Res. 1980 Dec;41(12):1947–1951. [PubMed]

Articles from The Canadian Veterinary Journal are provided here courtesy of Canadian Veterinary Medical Association

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...