• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of clinexpimmunolLink to Publisher's site
Clin Exp Immunol. Jun 1990; 80(3): 467–473.
PMCID: PMC1535196

Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.

Abstract

The influence of oestrogen on the lupus disease in MRL/l mice has been investigated. Adult, castrated male and female MRL/l mice were administered with s.c. injections of 3.2 micrograms of 17 beta-oestradiol twice a week. The results clearly demonstrate that a relatively small dose of oestrogen is a potent accelerator of the lupus disease in this mouse strain. Thus, administration of oestrogen accelerates glomerulonephritis, lymphoproliferation and mortality. Our results also indicate that oestrogen exerts a dual effect on the immune system of MRL/l mice by depression of antigen-specific and mitogen-induced T cell responses as well as enhancement of polyclonal B cell activation and autoantibody formation. In addition, even short-term administration of oestrogen in the preclinical phase of the disease resulted in long-lasting effects as evaluated by reduced longevity and aggravation of renal disease.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ansar Ahmed S, Dauphinée MJ, Montoya AI, Talal N. Estrogen induces normal murine CD5+ B cells to produce autoantibodies. J Immunol. 1989 Apr 15;142(8):2647–2653. [PubMed]
  • Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, Murphy ED, Roths JB, Dixon FJ. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med. 1978 Nov 1;148(5):1198–1215. [PMC free article] [PubMed]
  • Carlsten H, Nilsson LA, Tarkowski A. Impaired cutaneous delayed-type hypersensitivity in autoimmune MRL lpr/lpr mice. Int Arch Allergy Appl Immunol. 1986;81(4):322–325. [PubMed]
  • Carlsten H, Holmdahl R, Tarkowski A, Nilsson LA. Oestradiol suppression of delayed-type hypersensitivity in autoimmune (NZB/NZW)F1 mice is a trait inherited from the healthy NZW parental strain. Immunology. 1989 Jun;67(2):205–209. [PMC free article] [PubMed]
  • Carlsten H, Holmdahl R, Tarkowski A, Nilsson LA. Oestradiol- and testosterone-mediated effects on the immune system in normal and autoimmune mice are genetically linked and inherited as dominant traits. Immunology. 1989 Oct;68(2):209–214. [PMC free article] [PubMed]
  • Coulie PG, Van Snick J. Rheumatoid factor (RF) production during anamnestic immune responses in the mouse. III. Activation of RF precursor cells is induced by their interaction with immune complexes and carrier-specific helper T cells. J Exp Med. 1985 Jan 1;161(1):88–97. [PMC free article] [PubMed]
  • Czerkinsky CC, Nilsson LA, Nygren H, Ouchterlony O, Tarkowski A. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J Immunol Methods. 1983 Dec 16;65(1-2):109–121. [PubMed]
  • Elwing H, Nygren H. Diffusion in gel-enzyme linked immunosorbent assay (DIG-ELISA): a simple method for quantitation of class-specific antibodies. J Immunol Methods. 1979;31(1-2):101–107. [PubMed]
  • Gillis S, Ferm MM, Ou W, Smith KA. T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol. 1978 Jun;120(6):2027–2032. [PubMed]
  • Grossman CJ. Regulation of the immune system by sex steroids. Endocr Rev. 1984 Summer;5(3):435–455. [PubMed]
  • Holmdahl R, Carlsten H, Jansson L, Larsson P. Oestrogen is a potent immunomodulator of murine experimental rheumatoid disease. Br J Rheumatol. 1989;28 (Suppl 1):54–71. [PubMed]
  • Howie JB, Helyer BJ. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–266. [PubMed]
  • Jansson L, Holmdahl R. Oestrogen induced suppression of collagen arthritis. IV: Progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect. J Reprod Immunol. 1989 May;15(2):141–150. [PubMed]
  • Lahita RG. Sex steroids and the rheumatic diseases. Arthritis Rheum. 1985 Feb;28(2):121–126. [PubMed]
  • Lue C, Tarkowski A, Mestecky J. Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies. J Immunol. 1988 Jun 1;140(11):3793–3800. [PubMed]
  • Lycke N, Bromander AK, Ekman L, Karlsson U, Holmgren J. Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo. J Immunol. 1989 Jan 1;142(1):20–27. [PubMed]
  • Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. [PubMed]
  • MUND A, SIMSON J, ROTHFIELD N. Effect of pregnancy on course of systemic lupus erythematosus. JAMA. 1963 Mar 16;183:917–920. [PubMed]
  • Prud'homme GJ, Fieser TM, Dixon FJ, Theofilopoulos AN. B-cell-tropic interleukins in murine systemic lupus erythematosus (SLE) 1. Immunol Rev. 1984 Apr;78:159–183. [PubMed]
  • Rosenberg YJ, Malek TR, Schaeffer DE, Santoro TJ, Mark GE, Steinberg AD, Mountz JD. Unusual expression of IL 2 receptors and both the c-myb and c-raf oncogenes in T cell lines and clones derived from autoimmune MRL-lpr/lpr mice. J Immunol. 1985 May;134(5):3120–3123. [PubMed]
  • Roubinian JR, Talal N, Greenspan JS, Goodman JR, Siiteri PK. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. [PMC free article] [PubMed]
  • Russell MW, Brown TA, Radl J, Haaijman JJ, Mestecky J. Assay of human IgA subclass antibodies in serum and secretions by means of monoclonal antibodies. J Immunol Methods. 1986 Feb 27;87(1):87–93. [PubMed]
  • Shear HL, Wofsy D, Talal N. Effects of castration and sex hormones on immune clearance and autoimmune disease in MRL/Mp-lpr/lpr and MRL/Mp-+/+ mice. Clin Immunol Immunopathol. 1983 Mar;26(3):361–369. [PubMed]
  • Siiteri PK, Jones LA, Roubinian J, Talal N. Sex steroids and the immune system--I. Sex difference in autoimmune disease in NZB/NZW hybrid mice. J Steroid Biochem. 1980 Jan;12:425–432. [PubMed]
  • Steinberg AD, Melez KA, Raveche ES, Reeves JP, Boegel WA, Smathers PA, Taurog JD, Weinlein L, Duvic M. Approach to the study of the role of sex hormones in autoimmunity. Arthritis Rheum. 1979 Nov;22(11):1170–1176. [PubMed]
  • Steinberg AD, Roths JB, Murphy ED, Steinberg RT, Raveche ES. Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice. J Immunol. 1980 Aug;125(2):871–873. [PubMed]
  • Tarkowski A, Czerkinsky C, Nilsson LA. Detection of IgG rheumatoid factor secreting cells in autoimmune MRL/1 mice: a kinetic study. Clin Exp Immunol. 1984 Oct;58(1):7–12. [PMC free article] [PubMed]
  • Tarkowski A, Gunnarsson K, Stålhandske T. Effects of LS-2616 administration upon the autoimmune disease of (NZB x NZW) F1 hybrid mice. Immunology. 1986 Dec;59(4):589–594. [PMC free article] [PubMed]
  • Tarkowski A, Gunnarsson K, Nilsson LA, Lindholm L, Stålhandske T. Successful treatment of autoimmunity in MRL/1 mice with LS-2616, a new immunomodulator. Arthritis Rheum. 1986 Nov;29(11):1405–1409. [PubMed]
  • Tarkowski A, Jonsson R, Sanchez R, Klareskog L, Koopman WJ. Features of renal vasculitis in autoimmune MRL lpr/lpr mice: phenotypes and functional properties of infiltrating cells. Clin Exp Immunol. 1988 Apr;72(1):91–97. [PMC free article] [PubMed]
  • Theofilopoulos AN, Dixon FJ. Etiopathogenesis of murine SLE. Immunol Rev. 1981;55:179–216. [PubMed]
  • Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol. 1985;37:269–390. [PubMed]
  • Warren RW, Caster SA, Roths JB, Murphy ED, Pisetsky DS. The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains. Clin Immunol Immunopathol. 1984 Apr;31(1):65–77. [PubMed]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...