• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of clinexpimmunolLink to Publisher's site
Clin Exp Immunol. Nov 1990; 82(2): 326–332.
PMCID: PMC1535141

The expression of gamma delta T cell receptor and the prevalence of primed, activated and IgA-bound T cells in Behçet's syndrome.

Abstract

Mucosal ulceration of the oral, and to a lesser extent genital tissues is an essential feature of Behçet's syndrome and is associated with changes in the IgA class of immune responses. Indeed, a significant increase in the proportion of cytophilic IgA1 was found in circulating CD8 and CD4 cells (P less than 0.01), with a corresponding decrease in IgA-Fc receptors on these T cells. Furthermore, 30-40% of the cytophilic IgA1 on T cells may have been of the polymeric secretory type and the rest of the monomeric variety. IgA isotype of B cells was also significantly increased (P less than 0.001), without an overall change in circulating B cells. However, a surprising finding was the significant up-regulation of gamma delta T cell receptor in the CD8 (P less than 0.01) in the absence of a change in the proportion of alpha beta T cell receptor. The results suggest that some common microbial antigen might initiate at the mucosal surface an immune defence reaction characterized by T cells with gamma delta receptors and IgA-specific B cells. However, IgA1 bound to circulating T cells may down-regulate the central T cell function.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Beverley PC. Human T cell subsets. Immunol Lett. 1987 Apr;14(4):263–267. [PubMed]
  • Denman AM, Fialkow PJ, Pelton BK, Salo AC, Appleford DJ, Gilchrist C. Lymphocyte abnormalities in Behçet's syndrome. Clin Exp Immunol. 1980 Oct;42(1):175–185. [PMC free article] [PubMed]
  • Eglin RP, Lehner T, Subak-Sharpe JH. Detection of RNA complementary to herpes-simplex virus in mononuclear cells from patients with Behçet's syndrome and recurrent oral ulcers. Lancet. 1982 Dec 18;2(8312):1356–1361. [PubMed]
  • Endoh M, Sakai H, Nomoto Y, Tomino Y, Kaneshige H. IgA-specific helper activity of T alpha cells in human peripheral blood. J Immunol. 1981 Dec;127(6):2612–2613. [PubMed]
  • Fortune F, Lehner T. Phenotypic expression of Vicia villosa binding T cell subsets, as markers of contrasuppressor cells in systemic lupus erythematosus. Clin Exp Immunol. 1988 Oct;74(1):100–104. [PMC free article] [PubMed]
  • Fortune F, Kingston J, Barnes CS, Lehner T. Identification and characterization of IgA and Vicia villosa-binding T cell subsets in rheumatoid arthritis. Clin Exp Immunol. 1990 Feb;79(2):202–208. [PMC free article] [PubMed]
  • Janeway CA., Jr Frontiers of the immune system. Nature. 1988 Jun 30;333(6176):804–806. [PubMed]
  • Janis EM, Kaufmann SH, Schwartz RH, Pardoll DM. Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science. 1989 May 12;244(4905):713–716. [PubMed]
  • Kiyono H, Mosteller-Barnum LM, Pitts AM, Williamson SI, Michalek SM, McGhee JR. Isotype-specific immunoregulation. IgA-binding factors produced by Fc alpha receptor-positive T cell hybridomas regulate IgA responses. J Exp Med. 1985 Apr 1;161(4):731–747. [PMC free article] [PubMed]
  • Kozbor D, Trinchieri G, Monos DS, Isobe M, Russo G, Haney JA, Zmijewski C, Croce CM. Human TCR-gamma+/delta+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion. J Exp Med. 1989 May 1;169(5):1847–1851. [PMC free article] [PubMed]
  • Lehner T, Losito A, Williams DG. Cryoglobulins in Behçet's syndrome and recurrent oral ulceration: assay by laser nephelometry. Clin Exp Immunol. 1979 Dec;38(3):436–444. [PMC free article] [PubMed]
  • Lê thi Bich-Thuy, Revillard JP. Only T alpha or T gamma cells can be triggered by IgG or IgA to suppress the production of the matching Ig class. Eur J Immunol. 1986 Feb;16(2):156–161. [PubMed]
  • Levinsky RJ, Lehner T. Circulating soluble immume complexes in recurrent oral ulceration and Behçet's syndrome. Clin Exp Immunol. 1978 May;32(2):193–198. [PMC free article] [PubMed]
  • Mizushima Y. Recent research into Behçet's disease in Japan. Int J Tissue React. 1988;10(2):59–65. [PubMed]
  • Morimoto C, Letvin NL, Boyd AW, Hagan M, Brown HM, Kornacki MM, Schlossman SF. The isolation and characterization of the human helper inducer T cell subset. J Immunol. 1985 Jun;134(6):3762–3769. [PubMed]
  • Morimoto C, Letvin NL, Distaso JA, Aldrich WR, Schlossman SF. The isolation and characterization of the human suppressor inducer T cell subset. J Immunol. 1985 Mar;134(3):1508–1515. [PubMed]
  • O'Brien RL, Happ MP, Dallas A, Palmer E, Kubo R, Born WK. Stimulation of a major subset of lymphocytes expressing T cell receptor gamma delta by an antigen derived from Mycobacterium tuberculosis. Cell. 1989 May 19;57(4):667–674. [PubMed]
  • Reinherz EL, Kung PC, Pesando JM, Ritz J, Goldstein G, Schlossman SF. Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med. 1979 Dec 1;150(6):1472–1482. [PMC free article] [PubMed]
  • Victorino RM, Ryan P, Hughes GR, Hodgson HJ. Cell-mediated immune functions and immunoregulatory cells in Behçet's syndrome. Clin Exp Immunol. 1982 Apr;48(1):121–128. [PMC free article] [PubMed]
  • Yu DT, Winchester RJ, Fu SM, Gibofsky A, Ko HS, Kunkel HG. Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization. J Exp Med. 1980 Jan 1;151(1):91–100. [PMC free article] [PubMed]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...