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Br Med J (Clin Res Ed). Jan 24, 1981; 282(6260): 258–262.
PMCID: PMC1504057

Natural history of autoimmune thyroiditis.


One hundred and sixty-three asymptomatic people with thyroid antibodies or raised serum thyrotrophin (TSH) concentrations, or both, and 209 age-matched and sex-matched controls without either marker of thyroid disorder were followed up for four years to determine the natural history of autoimmune thyroiditis. Mildly raised TSH concentrations alone and the presence of thyroid antibodies alone did not significantly increase the risk of developing overt hypothyroidism during the four years compared with the controls. Overt hypothyroidism developed at the rate of 5% a year in women who initially had both raised TSH concentrations and thyroid antibodies. Prophylactic treatment with thyroxine may be justified in women found to have both markers of impending thyroid failure. The cost effectiveness of screening the adult population remains to be evaluated.

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Selected References

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  • Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 1977 Dec;7(6):481–493. [PubMed]
  • Gordin A, Heinonen OP, Saarinen P, Lamberg BA. Serum-thyrotrophin in symptomless autoimmune thyroiditis. Lancet. 1972 Mar 11;1(7750):551–554. [PubMed]
  • Gordin A, Maatela J, Miettinen A, Helenius T, Lamberg BA. Serum thyrotrophin and circulating thyroglobulin and thyroid microsomal antibodies in a Finnish population. Acta Endocrinol (Copenh) 1979 Jan;90(1):33–42. [PubMed]
  • GOUDIE RB, ANDERSON JR, GRAY KG. Complement-fixing antithyroid antibodies in hospital patients with asymptomatic thyroid lesions. J Pathol Bacteriol. 1959 Apr;77(2):389–400. [PubMed]
  • Bastenie PA, Bonnyns M, Neve P, Vanhaelst L, Chailly M. Clinical and pathological significance of asymptomatic atrophic thyroiditis. A condition of latent hypothyroidism. Lancet. 1967 Apr 29;1(7496):915–918. [PubMed]
  • WILLIAMS ED, DONIACH I. The post-mortem incidence of focal thyroiditis. J Pathol Bacteriol. 1962 Jan;83:255–264. [PubMed]
  • Wright BM, Dore CF. A random-zero sphygmomanometer. Lancet. 1970 Feb 14;1(7642):337–338. [PubMed]
  • Hall R, Amos J, Ormston BJ. Radioimmunoassay of human serum thyrotrophin. Br Med J. 1971 Mar 13;1(5749):582–585. [PMC free article] [PubMed]
  • Hesch RD, Evered D. Radioimmunoassay of triiodothyronine in unextracted human serum. Br Med J. 1973 Mar 17;1(5854):645–648. [PMC free article] [PubMed]
  • Clark F, Brown HJ. Evaluation of Thyopac-3 test in the in-vitro assessment of thyroid function. Br Med J. 1970 Mar 21;1(5698):713–715. [PMC free article] [PubMed]
  • FULTHORPE AJ, ROITT IM, DONIACH D, COUCHMAN K. A stable sheep cell preparation for detecing thyroglobulin auto-antibodies and its clinical applications. J Clin Pathol. 1961 Nov;14:654–660. [PMC free article] [PubMed]
  • Bird T, Stephenson J. Evaluation of a tanned red cell technique for thyroid microsomal antibodies. J Clin Pathol. 1973 Aug;26(8):623–627. [PMC free article] [PubMed]
  • Fletcher MJ. A colorimetric method for estimating serum triglycerides. Clin Chim Acta. 1968 Nov;22(3):393–397. [PubMed]
  • Gordin A, Lamberg BA. Natural course of symptomless autoimmune thyroiditis. Lancet. 1975 Dec 20;2(7947):1234–1238. [PubMed]
  • Kannel WB, Gordon T, Castelli WP, Margolis JR. Electrocardiographic left ventricular hypertrophy and risk of coronary heart disease. The Framingham study. Ann Intern Med. 1970 Jun;72(6):813–822. [PubMed]
  • Rose G. Predicting coronary heart disease from minor symptoms and electrocardiographic findings. Br J Prev Soc Med. 1971 May;25(2):94–96. [PMC free article] [PubMed]
  • Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA. Lipid profiles and cardiovascular disease in the Whickham area with particular reference to thyroid failure. Clin Endocrinol (Oxf) 1977 Dec;7(6):495–508. [PubMed]
  • Bastenie PA, Vanhaelst L, Bonnyns M, Neve P, Staquet M. Preclinical hypothyroidism: a risk factor for coronary heart-disease. Lancet. 1971 Jan 30;1(7692):203–204. [PubMed]
  • Fowler PS, Swale J. Premyxoedema and coronary-artery disease. Lancet. 1967 May 20;1(7499):1077–1079. [PubMed]
  • Fowler PB, Swale J, Andrews H. Hypercholesterolaemia in borderline hypothyroidism. Stage of premyxoedema. Lancet. 1970 Sep 5;2(7671):488–491. [PubMed]

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