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Ann Surg. Feb 1987; 205(2): 157–166.
PMCID: PMC1492814

Surgical treatment of Takayasu's disease.


Thirty-nine patients (mean age: 33 years) with Takayasu's disease were observed over the past 8 years. Among these patients, 33 had surgical intervention with a mean follow-up of 4 years. Lesions of the aortic arch were the most common (29 patients, 69 lesions) and frequently were associated with lesions in another site as well. However, in this group of patients, the infrequent presence of signs of cerebral vascular insufficiency limited the number of suitable surgical candidates to 14 patients. Lesions of the renal arteries were noted in 25 patients (37 lesions) and were associated with coarctation of the thoracoabdominal aorta in 12 patients. In contrast to lesions of the aortic arch, the presence of severe hypertension was a frequent indication for surgery in Takayasu's disease. Twenty-one patients had operation. Twenty of 21 patients were considered cured or improved of hypertension. The one patient who received no benefit was the only operative death of the study. In conclusion, although Takayasu's disease is progressive and the life expectancy is foreshortened, hypertension secondary to aortic and renal artery lesions is a frequent and important indication for aggressive operative treatment.

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Selected References

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  • Lupi-Herrera E, Sánchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE. Takayasu's arteritis. Clinical study of 107 cases. Am Heart J. 1977 Jan;93(1):94–103. [PubMed]
  • Nakao K, Ikeda M, Kimata S, Niitani H, Niyahara M. Takayasu's arteritis. Clinical report of eighty-four cases and immunological studies of seven cases. Circulation. 1967 Jun;35(6):1141–1155. [PubMed]
  • Kanaide H, Takeshita A, Nakamura M. Etiologic aspects of coagulopathy in Takayasu's aortitis. Am Heart J. 1982 Nov;104(5 Pt 1):1039–1045. [PubMed]
  • Chopra P, Datta RK, Dasgupta A, Bhargava S. Immunological studies in aortoarteritis. Indian J Med Res. 1982 Sep;76:436–443. [PubMed]
  • Adams DO. The granulomatous inflammatory response. A review. Am J Pathol. 1976 Jul;84(1):164–192. [PMC free article] [PubMed]
  • Tanabe T, Yokota A, Yasuda K. Pathogenesis and surgical treatment of aortitis syndrome. Jpn Circ J. 1982 Feb;46(2):194–200. [PubMed]
  • Ishikawa K. Natural history and classification of occlusive thromboaortopathy (Takayasu's disease). Circulation. 1978 Jan;57(1):27–35. [PubMed]
  • Teoh PC, Tan LK, Chia BL, Chao TC, Tambyah JA, Feng PH. Non-specific aorto-arteritis in Singapore with special reference to hypertension. Am Heart J. 1978 Jun;95(6):683–690. [PubMed]
  • "Pulmonary pulseless disease:" pulmonary involvement in so-called Takayasu's disease. Clinical Conference in Cardiology from the third medical division, Kyoto University Hospital, Kyoto, Japan. Chest. 1978 May;73(5):651–657. [PubMed]
  • Payan HM, Gilbert EF. Granulomatous coronary arteritis. Arch Pathol Lab Med. 1984 Feb;108(2):136–137. [PubMed]
  • Hejhal L, Hejnal J, Firt P. Coarctation of the abdominal aorta. J Cardiovasc Surg (Torino) 1973 Mar-Apr;14(2):168–177. [PubMed]
  • Lande A. Takayasu's arteritis and congenital coarctation of the descending thoracic and abdominal aorta: a critical review. AJR Am J Roentgenol. 1976 Aug;127(2):227–233. [PubMed]
  • Grossman E, Morag B, Nussinovitch N, Boichis H, Knecht A, Rosenthal T. Clinical use of captopril in Takayasu's disease. Arch Intern Med. 1984 Jan;144(1):95–96. [PubMed]
  • Hricik DE, Browning PJ, Kopelman R, Goorno WE, Madias NE, Dzau VJ. Captopril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney. N Engl J Med. 1983 Feb 17;308(7):373–376. [PubMed]
  • ASK-UPMARK E. On the pathogenesis of the hypertension in Takayashu's syndrome. Acta Med Scand. 1961 Apr;169:467–477. [PubMed]
  • Abe K, Miyazaki S, Kusaka T, Irokawa N, Aoyagi H. Elevated plasma renin activity in aortitis syndrome. Jpn Heart J. 1976 Jan;17(1):1–11. [PubMed]
  • Lagneau P, Michel JB. Renovascular hypertension and Takayasu's disease. J Urol. 1985 Nov;134(5):876–879. [PubMed]

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