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Can Med Assoc J. Jun 15, 1984; 130(12): 1580.
PMCID: PMC1483372

Cimetidine-induced fever.


Cimetidine is a rare cause of drug-induced fever. In a patient without evidence of hypersensitivity (the lymphocytes did not react to the drug in vitro) fever was the sole manifestation of an adverse reaction to cimetidine that was confirmed by challenge with the drug.

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Selected References

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  • Lipsky BA, Hirschmann JV. Drug fever. JAMA. 1981 Feb 27;245(8):851–854. [PubMed]
  • Ramboer C. [Drug fever with cimetidine]. Lancet. 1978 Feb 11;1(8059):330–331. [PubMed]
  • Warrington RJ, Tse KS. Lymphocyte transformation studies in drug hypersensitivity. Can Med Assoc J. 1979 May 5;120(9):1089–1094. [PMC free article] [PubMed]
  • Young EJ, Fainstein V, Musher DM. Drug-induced fever: cases seen in the evaluation of unexplained fever in a general hospital population. Rev Infect Dis. 1982 Jan-Feb;4(1):69–77. [PubMed]
  • Nisticò G, Rotiroti D, de Sarro A, Naccari F. Mechanism of cimetidine-induced fever. Lancet. 1978 Jul 29;2(8083):265–266. [PubMed]

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