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Environ Health Perspect. Sep 1997; 105(Suppl 5): 1013–1020.
PMCID: PMC1470126
Research Article

Surface reactivity in the pathogenic response to particulates.

Abstract

The peculiar characteristics of dust toxicity are discussed in relation to the processes taking place at the particle-biological medium interface. Because of surface reactivity, toxicity of solids is not merely predictable from chemical composition and molecular structure, as with water soluble compounds. With particles having the same bulk composition, micromorphology (the thermal and mechanical history of dust and adsorption from the environment) determines the kind and abundance of active surface sites, thus modulating reactivity toward cells and tissues. The quantitative evaluation of doses is discussed in comparisons of dose-response relationships obtained with different materials. Responses related to the surface of the particle are better compared on a per-unit surface than per-unit weight basis. The role of micromorphology, hydrophilicity, and reactive surface cations in determining the pathogenicity of inhaled particles is described with reference to silica and asbestos toxicity. Heating crystalline silica decreases hydrophilicity, with consequent modifications in membranolytic potential, retention, and transport. Transition metal ions exposed at the surface generate free radicals in aqueous suspensions. Continuous redox cycling of iron, with consequent activation-reactivation of the surface sites releasing free radicals, could account for the long-term pathogenicity caused by the inhalation of iron-containing fibers. In various pathogenicities caused by mixed dusts, the contact between components modifies toxicity. Hard metal lung disease is caused by exposure to mixtures of metals and carbides, typically cobalt (Co) and tungsten carbide (WC), but not to single components. Toxicity stems from reactive oxygen species generation in a mechanism involving both Co metal and WC in mutual contact. A relationship between the extent of water adsorption and biopersistence is proposed for vitreous fibers. Modifications of the surface taking place in vivo are described for ferruginous bodies and for the progressive comminution of chrysotile asbestos fibers.

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Selected References

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  • KING EJ, MOHANTY GP, HARRISON CV, NAGELSCHMIDT G. The action of different forms of pure silica on the lungs of rats. Br J Ind Med. 1953 Jan;10(1):9–17. [PMC free article] [PubMed]
  • ENGLEBRECHT FM, YOGANATHAN M, KING EJ, NAGELSCHMIDT G. Fibrosis and collagen in rats' lungs produced by etched and unetched free silica dusts. AMA Arch Ind Health. 1958 Apr;17(4):287–294. [PubMed]
  • Nash T, Allison AC, Harington JS. Physico-chemical properties of silica in relation to its toxicity. Nature. 1966 Apr 16;210(5033):259–261. [PubMed]
  • Harington JS, Allison AC, Badami DV. Mineral fibers: chemical, physicochemical, and biological properties. Adv Pharmacol Chemother. 1975;12(0):291–402. [PubMed]
  • Light WG, Wei ET. Surface charge and asbestos toxicity. Nature. 1977 Feb 10;265(5594):537–539. [PubMed]
  • Nolan RP, Langer AM, Harington JS, Oster G, Selikoff IJ. Quartz hemolysis as related to its surface functionalities. Environ Res. 1981 Dec;26(2):503–520. [PubMed]
  • Langer AM. Crystal faces and cleavage planes in quartz as templates in biological processes. Q Rev Biophys. 1978 Nov;11(4):543–575. [PubMed]
  • Fournier J, Pezerat H. Studies on surface properties of asbestos. III. Interactions between asbestos and polynuclear aromatic hydrocarbons. Environ Res. 1986 Oct;41(1):276–295. [PubMed]
  • Gerde P, Scholander P. Adsorption of benzo(a)pyrene on to asbestos and manmade mineral fibres in an aqueous solution and in a biological model solution. Br J Ind Med. 1988 Oct;45(10):682–688. [PMC free article] [PubMed]
  • Davis JM. Mixed fibrous and non-fibrous dust exposures and interactions between agents in fibre carcinogenesis. IARC Sci Publ. 1996;(140):127–135. [PubMed]
  • Lu J, Keane MJ, Ong T, Wallace WE. In vitro genotoxicity studies of chrysotile asbestos fibers dispersed in simulated pulmonary surfactant. Mutat Res. 1994 Mar;320(4):253–259. [PubMed]
  • Wiessner JH, Henderson JD, Jr, Sohnle PG, Mandel NS, Mandel GS. The effect of crystal structure on mouse lung inflammation and fibrosis. Am Rev Respir Dis. 1988 Aug;138(2):445–450. [PubMed]
  • Hemenway DR, Absher MP, Trombley L, Vacek PM. Comparative clearance of quartz and cristobalite from the lung. Am Ind Hyg Assoc J. 1990 Jul;51(7):363–369. [PubMed]
  • Fubini B, Bolis V, Cavenago A, Volante M. Physicochemical properties of crystalline silica dusts and their possible implication in various biological responses. Scand J Work Environ Health. 1995;21 (Suppl 2):9–14. [PubMed]
  • Daniel LN, Mao Y, Wang TC, Markey CJ, Markey SP, Shi X, Saffiotti U. DNA strand breakage, thymine glycol production, and hydroxyl radical generation induced by different samples of crystalline silica in vitro. Environ Res. 1995 Oct;71(1):60–73. [PubMed]
  • Fubini B, Giamello E, Volante M, Bolis V. Chemical functionalities at the silica surface determining its reactivity when inhaled. Formation and reactivity of surface radicals. Toxicol Ind Health. 1990 Dec;6(6):571–598. [PubMed]
  • Vallyathan V, Castranova V, Pack D, Leonard S, Shumaker J, Hubbs AF, Shoemaker DA, Ramsey DM, Pretty JR, McLaurin JL, et al. Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation. Potential role of free radicals. Am J Respir Crit Care Med. 1995 Sep;152(3):1003–1009. [PubMed]
  • Langer AM, Wolff MS, Rohl AN, Selikoff IJ. Variation of properties of chrysotile asbestos subjected to milling. J Toxicol Environ Health. 1978 Jan;4(1):173–188. [PubMed]
  • Nejjari A, Fournier J, Pezerat H, Leanderson P. Mineral fibres: correlation between oxidising surface activity and DNA base hydroxylation. Br J Ind Med. 1993 Jun;50(6):501–504. [PMC free article] [PubMed]
  • Miles PR, Bowman L, Jones WG, Berry DS, Vallyathan V. Changes in alveolar lavage materials and lung microsomal xenobiotic metabolism following exposures to HCl-washed or unwashed crystalline silica. Toxicol Appl Pharmacol. 1994 Dec;129(2):235–242. [PubMed]
  • Pandurangi RS, Seehra MS, Razzaboni BL, Bolsaitis P. Surface and bulk infrared modes of crystalline and amorphous silica particles: a study of the relation of surface structure to cytotoxicity of respirable silica. Environ Health Perspect. 1990 Jun;86:327–336. [PMC free article] [PubMed]
  • Hemenway DR, Absher MP, Fubini B, Bolis V. What is the relationship between hemolytic potential and fibrogenicity of mineral dusts? Arch Environ Health. 1993 Sep-Oct;48(5):343–347. [PubMed]
  • Hobson J, Wright JL, Churg A. Active oxygen species mediate asbestos fiber uptake by tracheal epithelial cells. FASEB J. 1990 Oct;4(13):3135–3139. [PubMed]
  • Sesko A, Cabot M, Mossman B. Hydrolysis of inositol phospholipids precedes cellular proliferation in asbestos-stimulated tracheobronchial epithelial cells. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7385–7389. [PMC free article] [PubMed]
  • Oberdörster G, Ferin J, Lehnert BE. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect. 1994 Oct;102 (Suppl 5):173–179. [PMC free article] [PubMed]
  • Gilmour PS, Beswick PH, Brown DM, Donaldson K. Detection of surface free radical activity of respirable industrial fibres using supercoiled phi X174 RF1 plasmid DNA. Carcinogenesis. 1995 Dec;16(12):2973–2979. [PubMed]
  • Hill IM, Beswick PH, Donaldson K. Differential release of superoxide anions by macrophages treated with long and short fibre amosite asbestos is a consequence of differential affinity for opsonin. Occup Environ Med. 1995 Feb;52(2):92–96. [PMC free article] [PubMed]
  • Wiessner JH, Mandel NS, Sohnle PG, Hasegawa A, Mandel GS. The effect of chemical modification of quartz surfaces on particulate-induced pulmonary inflammation and fibrosis in the mouse. Am Rev Respir Dis. 1990 Jan;141(1):111–116. [PubMed]
  • Kamp DW, Graceffa P, Pryor WA, Weitzman SA. The role of free radicals in asbestos-induced diseases. Free Radic Biol Med. 1992;12(4):293–315. [PubMed]
  • Gulumian M, van Wyk JA. Hydroxyl radical production in the presence of fibres by a Fenton-type reaction. Chem Biol Interact. 1987;62(1):89–97. [PubMed]
  • Leanderson P, Söderkvist P, Tagesson C, Axelson O. Formation of 8-hydroxydeoxyguanosine by asbestos and man made mineral fibres. Br J Ind Med. 1988 May;45(5):309–311. [PMC free article] [PubMed]
  • Pezerat H, Guignard J, Cherrie JW. Man-made mineral fibers and lung cancer: an hypothesis. Toxicol Ind Health. 1992 Jan-Apr;8(1-2):77–87. [PubMed]
  • Elias Z, Poirot O, Schneider O, Marande AM, Danière MC, Terzetti F, Pezerat H, Fournier J, Zalma R. Cytotoxic and transforming effects of some iron-containing minerals in Syrian hamster embryo cells. Cancer Detect Prev. 1995;19(5):405–414. [PubMed]
  • Fubini B, Mollo L. Role of iron in the reactivity of mineral fibers. Toxicol Lett. 1995 Dec;82-83:951–960. [PubMed]
  • Pezerat H, Zalma R, Guignard J, Jaurand MC. Production of oxygen radicals by the reduction of oxygen arising from the surface activity of mineral fibres. IARC Sci Publ. 1989;(90):100–111. [PubMed]
  • Fubini B, Mollo L, Giamello E. Free radical generation at the solid/liquid interface in iron containing minerals. Free Radic Res. 1995 Dec;23(6):593–614. [PubMed]
  • Lund LG, Aust AE. Iron mobilization from crocidolite asbestos greatly enhances crocidolite-dependent formation of DNA single-strand breaks in phi X174 RFI DNA. Carcinogenesis. 1992 Apr;13(4):637–642. [PubMed]
  • Guilianelli C, Baeza-Squiban A, Boisvieux-Ulrich E, Houcine O, Zalma R, Guennou C, Pezerat H, Marano F. Effect of mineral particles containing iron on primary cultures of rabbit tracheal epithelial cells: possible implication of oxidative stress. Environ Health Perspect. 1993 Oct;101(5):436–442. [PMC free article] [PubMed]
  • Adachi S, Yoshida S, Kawamura K, Takahashi M, Uchida H, Odagiri Y, Takemoto K. Inductions of oxidative DNA damage and mesothelioma by crocidolite, with special reference to the presence of iron inside and outside of asbestos fiber. Carcinogenesis. 1994 Apr;15(4):753–758. [PubMed]
  • Ghio AJ, Kennedy TP, Stonehuerner JG, Crumbliss AL, Hoidal JR. DNA strand breaks following in vitro exposure to asbestos increase with surface-complexed [Fe3+]. Arch Biochem Biophys. 1994 May 15;311(1):13–18. [PubMed]
  • Sébastien P. Biopersistence of man-made vitreous silicate fibers in the human lung. Environ Health Perspect. 1994 Oct;102 (Suppl 5):225–228. [PMC free article] [PubMed]
  • Lison D. Human toxicity of cobalt-containing dust and experimental studies on the mechanism of interstitial lung disease (hard metal disease). Crit Rev Toxicol. 1996 Nov;26(6):585–616. [PubMed]
  • Lison D, Lauwerys R, Demedts M, Nemery B. Experimental research into the pathogenesis of cobalt/hard metal lung disease. Eur Respir J. 1996 May;9(5):1024–1028. [PubMed]
  • Lison D, Carbonnelle P, Mollo L, Lauwerys R, Fubini B. Physicochemical mechanism of the interaction between cobalt metal and carbide particles to generate toxic activated oxygen species. Chem Res Toxicol. 1995 Jun;8(4):600–606. [PubMed]
  • Musselman RP, Miiller WC, Eastes W, Hadley JG, Kamstrup O, Thevenaz P, Hesterberg TW. Biopersistences of man-made vitreous fibers and crocidolite fibers in rat lungs following short-term exposures. Environ Health Perspect. 1994 Oct;102 (Suppl 5):139–143. [PMC free article] [PubMed]
  • Gold J, Amandusson H, Krozer A, Kasemo B, Ericsson T, Zanetti G, Fubini B. Chemical characterization and reactivity of iron chelator-treated amphibole asbestos. Environ Health Perspect. 1997 Sep;105 (Suppl 5):1021–1030. [PMC free article] [PubMed]
  • Governa M, Rosanda C. A histochemical study of the asbestos body coating. Br J Ind Med. 1972 Apr;29(2):154–159. [PMC free article] [PubMed]
  • Churg AM, Warnock ML. Asbestos and other ferruginous bodies: their formation and clinical significance. Am J Pathol. 1981 Mar;102(3):447–456. [PMC free article] [PubMed]
  • Morgan A, Holmes A. The enigmatic asbestos body: its formation and significance in asbestos-related disease. Environ Res. 1985 Dec;38(2):283–292. [PubMed]
  • Murai Y, Kitagawa M, Hiraoka T. Asbestos body formation in the human lung: distinctions, by type and size. Arch Environ Health. 1995 Jan-Feb;50(1):19–25. [PubMed]
  • Lund LG, Williams MG, Dodson RF, Aust AE. Iron associated with asbestos bodies is responsible for the formation of single strand breaks in phi X174 RFI DNA. Occup Environ Med. 1994 Mar;51(3):200–204. [PMC free article] [PubMed]
  • Jaurand MC, Gaudichet A, Halpern S, Bignon J. In vitro biodegradation of chrysotile fibres by alveolar macrophages and mesothelial cells in culture: comparison with a pH effect. Br J Ind Med. 1984 Aug;41(3):389–395. [PMC free article] [PubMed]
  • Jaurand MC, Magne L, Boulmier JL, Bignon J. In vitro reactivity of alveolar macrophages and red blood cells with asbestos fibres treated with oxalic acid, sulfur dioxide and benzo-3,4-pyrene. Toxicology. 1981;21(4):323–342. [PubMed]

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