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Genetics. Nov 2003; 165(3): 1619–1622.
PMCID: PMC1462824

Effect of misoriented sites on neutrality tests with outgroup.

Abstract

Several neutrality tests use outgroups to infer the ancestral and derived states for polymorphism data. However, homoplasy can result in the incorrect inference of the derived variant. We show that empirically derived rates of misorientation strongly influence Fay and Wu's H-test, especially when the sample size is large.

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Selected References

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