• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Dec 2002; 162(4): 2049–2052.
PMCID: PMC1462354

Context dependence of meiotic recombination hotspots in yeast: the relationship between recombination activity of a reporter construct and base composition.

Abstract

Borde and colleagues reported that a reporter plasmid inserted at different genomic locations in Saccharomyces cerevisiae had different levels of meiotic recombination activity. We show that the level of recombination activity is very significantly correlated with the GC content of DNA sequences flanking the insertion.

Full Text

The Full Text of this article is available as a PDF (66K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Lichten M, Goldman AS. Meiotic recombination hotspots. Annu Rev Genet. 1995;29:423–444. [PubMed]
  • Marais G, Mouchiroud D, Duret L. Does recombination improve selection on codon usage? Lessons from nematode and fly complete genomes. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5688–5692. [PMC free article] [PubMed]
  • Baudat F, Nicolas A. Clustering of meiotic double-strand breaks on yeast chromosome III. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5213–5218. [PMC free article] [PubMed]
  • Petes TD. Meiotic recombination hot spots and cold spots. Nat Rev Genet. 2001 May;2(5):360–369. [PubMed]
  • Birdsell John A. Integrating genomics, bioinformatics, and classical genetics to study the effects of recombination on genome evolution. Mol Biol Evol. 2002 Jul;19(7):1181–1197. [PubMed]
  • Stapleton A, Petes TD. The Tn3 beta-lactamase gene acts as a hotspot for meiotic recombination in yeast. Genetics. 1991 Jan;127(1):39–51. [PMC free article] [PubMed]
  • White MA, Detloff P, Strand M, Petes TD. A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast. Curr Genet. 1992 Feb;21(2):109–116. [PubMed]
  • Eisenbarth I, Striebel AM, Moschgath E, Vogel W, Assum G. Long-range sequence composition mirrors linkage disequilibrium pattern in a 1.13 Mb region of human chromosome 22. Hum Mol Genet. 2001 Nov 15;10(24):2833–2839. [PubMed]
  • White MA, Dominska M, Petes TD. Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6621–6625. [PMC free article] [PubMed]
  • Eyre-Walker A. Recombination and mammalian genome evolution. Proc Biol Sci. 1993 Jun 22;252(1335):237–243. [PubMed]
  • Wu TC, Lichten M. Meiosis-induced double-strand break sites determined by yeast chromatin structure. Science. 1994 Jan 28;263(5146):515–518. [PubMed]
  • Galtier N, Piganeau G, Mouchiroud D, Duret L. GC-content evolution in mammalian genomes: the biased gene conversion hypothesis. Genetics. 2001 Oct;159(2):907–911. [PMC free article] [PubMed]
  • Wu TC, Lichten M. Factors that affect the location and frequency of meiosis-induced double-strand breaks in Saccharomyces cerevisiae. Genetics. 1995 May;140(1):55–66. [PMC free article] [PubMed]
  • Gerton JL, DeRisi J, Shroff R, Lichten M, Brown PO, Petes TD. Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11383–11390. [PMC free article] [PubMed]
  • Zickler D, Kleckner N. Meiotic chromosomes: integrating structure and function. Annu Rev Genet. 1999;33:603–754. [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...