Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. 2002 Jun; 161(2): 931–938.
PMCID: PMC1462155

On the detection of imprinted quantitative trait loci in experimental crosses of outbred species.


In this article, the quantitative genetic aspects of imprinted genes and statistical properties of methods to detect imprinted QTL are studied. Different models to detect imprinted QTL and to distinguish between imprinted and Mendelian QTL were compared in a simulation study. Mendelian and imprinted QTL were simulated in an F2 design and analyzed under Mendelian and imprinting models. Mode of expression was evaluated against the H(0) of a Mendelian QTL as well as the H(0) of an imprinted QTL. It was shown that imprinted QTL might remain undetected when analyzing the genome with Mendelian models only. Compared to testing against a Mendelian QTL, using the H(0) of an imprinted QTL gave a higher proportion of correctly identified imprinted QTL, but also gave a higher proportion of false inference of imprinting for Mendelian QTL. When QTL were segregating in the founder lines, spurious detection of imprinting became more prominent under both tests, especially for designs with a small number of F1 sires.

Full Text

The Full Text of this article is available as a PDF (81K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Hoeschele I, Uimari P, Grignola FE, Zhang Q, Gage KM. Advances in statistical methods to map quantitative trait loci in outbred populations. Genetics. 1997 Nov;147(3):1445–1457. [PMC free article] [PubMed]
  • Haley CS, Knott SA, Elsen JM. Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics. 1994 Mar;136(3):1195–1207. [PMC free article] [PubMed]
  • Jeon JT, Carlborg O, Törnsten A, Giuffra E, Amarger V, Chardon P, Andersson-Eklund L, Andersson K, Hansson I, Lundström K, et al. A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nat Genet. 1999 Feb;21(2):157–158. [PubMed]
  • Knott SA, Marklund L, Haley CS, Andersson K, Davies W, Ellegren H, Fredholm M, Hansson I, Hoyheim B, Lundström K, et al. Multiple marker mapping of quantitative trait loci in a cross between outbred wild boar and large white pigs. Genetics. 1998 Jun;149(2):1069–1080. [PMC free article] [PubMed]
  • Alleman M, Doctor J. Genomic imprinting in plants: observations and evolutionary implications. Plant Mol Biol. 2000 Jun;43(2-3):147–161. [PubMed]
  • Lloyd VK, Sinclair DA, Grigliatti TA. Genomic imprinting and position-effect variegation in Drosophila melanogaster. Genetics. 1999 Apr;151(4):1503–1516. [PMC free article] [PubMed]
  • Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics. 1994 Nov;138(3):963–971. [PMC free article] [PubMed]
  • Clapcott SJ, Teale AJ, Kemp SJ. Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice. Parasite Immunol. 2000 May;22(5):259–263. [PubMed]
  • Morison IM, Paton CJ, Cleverley SD. The imprinted gene and parent-of-origin effect database. Nucleic Acids Res. 2001 Jan 1;29(1):275–276. [PMC free article] [PubMed]
  • de Koning DJ, Rattink AP, Harlizius B, van Arendonk JA, Brascamp EW, Groenen MA. Genome-wide scan for body composition in pigs reveals important role of imprinting. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7947–7950. [PMC free article] [PubMed]
  • Nezer C, Moreau L, Brouwers B, Coppieters W, Detilleux J, Hanset R, Karim L, Kvasz A, Leroy P, Georges M. An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nat Genet. 1999 Feb;21(2):155–156. [PubMed]
  • Sillanpä MJ, Arjas E. Bayesian mapping of multiple quantitative trait loci from incomplete outbred offspring data. Genetics. 1999 Apr;151(4):1605–1619. [PMC free article] [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...