• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Nov 2001; 159(3): 1319–1323.
PMCID: PMC1461858

Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits.

Abstract

Association studies using random population samples are increasingly being applied in the identification and inference of genetic effects of genes underlying complex traits. It is well recognized that population admixture may yield false-positive identification of genetic effects for complex traits. However, it is less well appreciated that population admixture can appear to mask, change, or reverse true genetic effects for genes underlying complex traits. By employing a simple population genetics model, we explore the effects and the conditions of population admixture in masking, changing, or even reversing true genetic effects of genes underlying complex traits.

Full Text

The Full Text of this article is available as a PDF (74K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Allison DB. Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet. 1997 Mar;60(3):676–690. [PMC free article] [PubMed]
  • Chakraborty R, Smouse PE. Recombination of haplotypes leads to biased estimates of admixture proportions in human populations. Proc Natl Acad Sci U S A. 1988 May;85(9):3071–3074. [PMC free article] [PubMed]
  • Deng HW, Chen WM. Re: "Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions". Am J Epidemiol. 2000 Feb 1;151(3):335–337. [PubMed]
  • Deng HW, Chen WM. QTL fine mapping, in extreme samples of finite populations, for complex traits with familial correlation due to polygenes. Am J Hum Genet. 2000 Jul;67(1):259–262. [PMC free article] [PubMed]
  • Deng HW, Li J, Li JL, Johnson M, Gong G, Recker RR. Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: different conclusions with different analyses and the implications. Osteoporos Int. 1999;9(6):499–507. [PubMed]
  • Deng HW, Chen WM, Recker S, Stegman MR, Li JL, Davies KM, Zhou Y, Deng H, Heaney R, Recker RR. Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture. J Bone Miner Res. 2000 Jul;15(7):1243–1252. [PubMed]
  • Deng HW, Chen WM, Recker RR. QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations. Am J Hum Genet. 2000 Mar;66(3):1027–1045. [PMC free article] [PubMed]
  • Deng HW, Chen WM, Recker RR. Population admixture: detection by Hardy-Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits. Genetics. 2001 Feb;157(2):885–897. [PMC free article] [PubMed]
  • Eisman JA. Vitamin D receptor gene alleles and osteoporosis: an affirmative view. J Bone Miner Res. 1995 Sep;10(9):1289–1293. [PubMed]
  • Gong G, Stern HS, Cheng SC, Fong N, Mordeson J, Deng HW, Recker RR. The association of bone mineral density with vitamin D receptor gene polymorphisms. Osteoporos Int. 1999;9(1):55–64. [PubMed]
  • Houston LA, Grant SF, Reid DM, Ralston SH. Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population. Bone. 1996 Mar;18(3):249–252. [PubMed]
  • Morton NE, Collins A. Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11389–11393. [PMC free article] [PubMed]
  • Peacock M. Vitamin D receptor gene alleles and osteoporosis: a contrasting view. J Bone Miner Res. 1995 Sep;10(9):1294–1297. [PubMed]
  • Risch N, Teng J. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling. Genome Res. 1998 Dec;8(12):1273–1288. [PubMed]
  • Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet. 1993 Mar;52(3):506–516. [PMC free article] [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...