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Genetics. 2001 Jun; 158(2): 913–917.
PMCID: PMC1461672

Recessive mutations and the maintenance of sex in structured populations.


The evolutionary maintenance of sexual reproduction remains a controversial problem. It was recently shown that recessive deleterious mutations create differences in the mutation load of sexual vs. asexual populations. Here we show that low levels of population structure or inbreeding can greatly enhance the importance of recessive deleterious mutations in the context of sexual vs. asexual populations. With population structure, the cost of sex can be substantially reduced or even eliminated for realistic levels of dominance.

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Selected References

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  • Barton NH, Charlesworth B. Why sex and recombination? Science. 1998 Sep 25;281(5385):1986–1990. [PubMed]
  • Charlesworth B. The cost of sex in relation to mating system. J Theor Biol. 1980 Jun 21;84(4):655–671. [PubMed]
  • Charlesworth B. Mutation-selection balance and the evolutionary advantage of sex and recombination. Genet Res. 1990 Jun;55(3):199–221. [PubMed]
  • Chasnov JR. Mutation-selection balance, dominance and the maintenance of sex. Genetics. 2000 Nov;156(3):1419–1425. [PMC free article] [PubMed]
  • Elena SF, Lenski RE. Test of synergistic interactions among deleterious mutations in bacteria. Nature. 1997 Nov 27;390(6658):395–398. [PubMed]
  • García-Dorado A, Caballero A. On the average coefficient of dominance of deleterious spontaneous mutations. Genetics. 2000 Aug;155(4):1991–2001. [PMC free article] [PubMed]
  • Howard RS. Selection against deleterious mutations and the maintenance of biparental sex. Theor Popul Biol. 1994 Jun;45(3):313–323. [PubMed]
  • Howard RS, Lively CM. Parasitism, mutation accumulation and the maintenance of sex. Nature. 1994 Feb 10;367(6463):554–557. [PubMed]
  • Keightley PD, Eyre-Walker A. Terumi Mukai and the riddle of deleterious mutation rates. Genetics. 1999 Oct;153(2):515–523. [PMC free article] [PubMed]
  • Keightley PD, Eyre-Walker A. Deleterious mutations and the evolution of sex. Science. 2000 Oct 13;290(5490):331–333. [PubMed]
  • Kimura M, Maruyama T. The mutational load with epistatic gene interactions in fitness. Genetics. 1966 Dec;54(6):1337–1351. [PMC free article] [PubMed]
  • Kondrashov AS. Selection against harmful mutations in large sexual and asexual populations. Genet Res. 1982 Dec;40(3):325–332. [PubMed]
  • Kondrashov AS. Deleterious mutations and the evolution of sexual reproduction. Nature. 1988 Dec 1;336(6198):435–440. [PubMed]
  • Kondrashov AS. Classification of hypotheses on the advantage of amphimixis. J Hered. 1993 Sep-Oct;84(5):372–387. [PubMed]
  • Lenormand T, Otto SP. The evolution of recombination in a heterogeneous environment. Genetics. 2000 Sep;156(1):423–438. [PMC free article] [PubMed]
  • MULLER HJ. Our load of mutations. Am J Hum Genet. 1950 Jun;2(2):111–176. [PMC free article] [PubMed]
  • Peck JR, Waxman D. Mutation and sex in a competitive world. Nature. 2000 Jul 27;406(6794):399–404. [PubMed]
  • Szathmáry E. Do deleterious mutations act synergistically? Metabolic control theory provides a partial answer. Genetics. 1993 Jan;133(1):127–132. [PMC free article] [PubMed]

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