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Genetics. Jul 2000; 155(3): 1449–1458.
PMCID: PMC1461143

Zygotic associations and multilocus statistics in a nonequilibrium diploid population.

Abstract

The usual approach to characterizing and estimating multilocus associations in a diploid population assumes that the population is in Hardy-Weinberg equilibrium. The purpose of this study is to develop a set of summary statistics that can be used to characterize and estimate the multilocus associations in a nonequilibrium population. The concept of "zygotic associations" is first expanded to facilitate the development. The summary statistics are calculated using the distribution of a random variable, the number of heterozygous loci (K) found in diploid individuals in the population. In particular, the variance of K consists of single-locus and multilocus components with the latter being the sum of zygotic associations between pairs of loci. Simulation results show that the multilocus associations in the variance of K are detectable in a sample of moderate size (> or =30) when the sum of all pairwise zygotic associations is greater than zero and when gene frequency is intermediate. The method presented here is a generalization of the well-known development for the Hardy-Weinberg equilibrium population and thus may be of more general use in elucidating the multilocus organizations in nonequilibrium and equilibrium populations.

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Selected References

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  • Brown AH, Feldman MW. Population structure of multilocus associations. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5913–5916. [PMC free article] [PubMed]
  • Brown AH, Feldman MW, Nevo E. Multilocus Structure of Natural Populations of HORDEUM SPONTANEUM. Genetics. 1980 Oct;96(2):523–536. [PMC free article] [PubMed]
  • Clegg MT, Kidwell JF, Kidwell MG, Daniel NJ. Dynamics of correlated genetic systems. I. Selection in the region of the Glued locus of Drosophila melanogaster. Genetics. 1976 Aug;83(4):793–810. [PMC free article] [PubMed]
  • Cockerham CC, Weir BS. Descent measures for two loci with some applications. Theor Popul Biol. 1973 Sep;4(3):300–330. [PubMed]
  • Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics. 1992 Jun;48(2):361–372. [PubMed]
  • HALDANE JBS. The association of characters as a result of inbreeding and linkage. Ann Eugen. 1949 Oct;15(1):15–23. [PubMed]
  • Haubold B, Travisano M, Rainey PB, Hudson RR. Detecting linkage disequilibrium in bacterial populations. Genetics. 1998 Dec;150(4):1341–1348. [PMC free article] [PubMed]
  • Hedrick PW. Gametic disequilibrium measures: proceed with caution. Genetics. 1987 Oct;117(2):331–341. [PMC free article] [PubMed]
  • Weir BS, Cockerham CC. Mixed self and random mating at two loci. Genet Res. 1973 Jun;21(3):247–262. [PubMed]
  • Karlin S, Piazza A. Statistical methods for assessing linkage disequilibrium at the HLA-A, B, C loci. Ann Hum Genet. 1981 Feb;45(Pt 1):79–94. [PubMed]
  • Weir BS, Reynolds J, Dodds KG. The variance of sample heterozygosity. Theor Popul Biol. 1990 Feb;37(1):235–253. [PubMed]
  • Whittam TS, Ochman H, Selander RK. Multilocus genetic structure in natural populations of Escherichia coli. Proc Natl Acad Sci U S A. 1983 Mar;80(6):1751–1755. [PMC free article] [PubMed]
  • Smith JM, Smith NH, O'Rourke M, Spratt BG. How clonal are bacteria? Proc Natl Acad Sci U S A. 1993 May 15;90(10):4384–4388. [PMC free article] [PubMed]

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