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Genetics. Jul 2000; 155(3): 1439–1447.
PMCID: PMC1461139

Multipoint mapping of viability and segregation distorting loci using molecular markers.

Abstract

In line-crossing experiments, deviations from Mendelian segregation ratios are usually observed for some markers. We hypothesize that these deviations are caused by one or more segregation-distorting loci (SDL) linked to the markers. We develop both a maximum-likelihood (ML) method and a Bayesian method to map SDL using molecular markers. The ML mapping is implemented via an EM algorithm and the Bayesian method is performed via the Markov chain Monte Carlo (MCMC). The Bayesian mapping is computationally more intensive than the ML mapping but can handle more complicated models such as multiple SDL and variable number of SDL. Both methods are applied to a set of simulated data and real data from a cross of two Scots pine trees.

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Selected References

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  • Lander ES, Botstein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989 Jan;121(1):185–199. [PMC free article] [PubMed]
  • Lander ES, Green P. Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2363–2367. [PMC free article] [PubMed]
  • Fu YB, Ritland K. Evidence for the partial dominance of viability genes contributing to inbreeding depression in Mimulus guttatus. Genetics. 1994 Jan;136(1):323–331. [PMC free article] [PubMed]
  • Mitchell-Olds T. Interval mapping of viability loci causing heterosis in Arabidopsis. Genetics. 1995 Jul;140(3):1105–1109. [PMC free article] [PubMed]
  • Heath SC. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet. 1997 Sep;61(3):748–760. [PMC free article] [PubMed]
  • Hedrick PW. Purging inbreeding depression and the probability of extinction: full-sib mating. Heredity (Edinb) 1994 Oct;73(Pt 4):363–372. [PubMed]
  • Sillanpä MJ, Arjas E. Bayesian mapping of multiple quantitative trait loci from incomplete inbred line cross data. Genetics. 1998 Mar;148(3):1373–1388. [PMC free article] [PubMed]
  • Jansen RC, Stam P. High resolution of quantitative traits into multiple loci via interval mapping. Genetics. 1994 Apr;136(4):1447–1455. [PMC free article] [PubMed]
  • Jiang C, Zeng ZB. Mapping quantitative trait loci with dominant and missing markers in various crosses from two inbred lines. Genetica. 1997;101(1):47–58. [PubMed]
  • Whitkus R. Genetics of adaptive radiation in Hawaiian and Cook Islands species of Tetramolopium (Asteraceae). II. Genetic linkage map and its implications for interspecific breeding barriers. Genetics. 1998 Nov;150(3):1209–1216. [PMC free article] [PubMed]
  • Zeng ZB. Precision mapping of quantitative trait loci. Genetics. 1994 Apr;136(4):1457–1468. [PMC free article] [PubMed]

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