• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Jan 2000; 154(1): 343–350.
PMCID: PMC1460928

Sex-of-offspring-specific transmission ratio distortion on mouse chromosome X.

Abstract

During our study of the DDK syndrome, we observed sex ratio distortion in favor of males among the offspring of F(1) backcrosses between the C57BL/6 and DDK strains. We also observed significant and reproducible transmission ratio distortion in favor of the inheritance of DDK alleles at loci on chromosome X among female offspring but not among male offspring in (C57BL/6 x DDK)F(1) x C57BL/6 and (C57BL/6-Pgk1(a) x DDK)F(1) x C57BL/6 backcrosses. The observed transmission ratio distortion is maximum at DXMit210 in the central region of chromosome X and decreases progressively at proximal and distal loci, in a manner consistent with the predictions of a single distorted locus model. DXMit210 is closely linked to two distortion-controlling loci (Dcsx1 and Dcsx2) described previously in interspecific backcrosses. Our analysis suggests that the female-offspring-specific transmission ratio distortion we observe is likely to be the result of the death of embryos of particular genotypic combinations. In addition, we confirm the previous suggestion that the transmission ratio distortion observed on chromosome X in interspecific backcrosses is also the result of loss of embryos.

Full Text

The Full Text of this article is available as a PDF (97K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Babinet C, Richoux V, Guénet JL, Renard JP. The DDK inbred strain as a model for the study of interactions between parental genomes and egg cytoplasm in mouse preimplantation development. Dev Suppl. 1990:81–87. [PubMed]
  • Biddle FG. Segregation distortion of X-linked marker genes in interspecific crosses between Mus musculus and M. spretus. Genome. 1987 Apr;29(2):389–392. [PubMed]
  • Boyd Y. Non-mendelian inheritance of X chromosome markers in interspecific backcrosses. Nat Genet. 1996 Aug;13(4):393–394. [PubMed]
  • Pardo-Manuel de Villena F, de la Casa-Esperón E, Verner A, Morgan K, Sapienza C. The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om. Mamm Genome. 1999 May;10(5):492–497. [PubMed]
  • Pardo-Manuel de Villena F, de la Casa-Esperon E, Briscoe TL, Sapienza C. A genetic test to determine the origin of maternal transmission ratio distortion. Meiotic drive at the mouse Om locus. Genetics. 2000 Jan;154(1):333–342. [PMC free article] [PubMed]
  • Gubbay J, Collignon J, Koopman P, Capel B, Economou A, Münsterberg A, Vivian N, Goodfellow P, Lovell-Badge R. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature. 1990 Jul 19;346(6281):245–250. [PubMed]
  • Pardo-Manuel de Villena F, de la Casa-Esperon E, Briscoe TL, Malette JM, Sapienza C. Male-offspring-specific, haplotype-dependent, nonrandom cosegregation of alleles at loci on two mouse chromosomes. Genetics. 2000 Jan;154(1):351–356. [PMC free article] [PubMed]
  • Renard JP, Babinet C. Identification of a paternal developmental effect on the cytoplasm of one-cell-stage mouse embryos. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6883–6886. [PMC free article] [PubMed]
  • Renard JP, Baldacci P, Richoux-Duranthon V, Pournin S, Babinet C. A maternal factor affecting mouse blastocyst formation. Development. 1994 Apr;120(4):797–802. [PubMed]
  • Johnson KR, Cook SA, Davisson MT. Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse. Mamm Genome. 1994 Nov;5(11):670–687. [PubMed]
  • Renard JP, Baldacci P, Richoux-Duranthon V, Pournin S, Babinet C. A maternal factor affecting mouse blastocyst formation. Development. 1994 Apr;120(4):797–802. [PubMed]
  • Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MS, Thurston SJ, Birkenmeier EH. Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm Genome. 1994 May;5(5):253–274. [PubMed]
  • Sapienza C, Paquette J, Pannunzio P, Albrechtson S, Morgan K. The polar-lethal Ovum mutant gene maps to the distal portion of mouse chromosome 11. Genetics. 1992 Sep;132(1):241–246. [PMC free article] [PubMed]
  • Simmler MC, Cattanach BM, Rasberry C, Rougeulle C, Avner P. Mapping the murine Xce locus with (CA)n repeats. Mamm Genome. 1993 Sep;4(9):523–530. [PubMed]
  • Wakasugi N. Studies on fertility of DDK mice: reciprocal crosses between DDK and C57BL/6J strains and experimental transplantation of the ovary. J Reprod Fertil. 1973 May;33(2):283–291. [PubMed]
  • Naumova AK, Leppert M, Barker DF, Morgan K, Sapienza C. Parental origin-dependent, male offspring-specific transmission-ratio distortion at loci on the human X chromosome. Am J Hum Genet. 1998 Jun;62(6):1493–1499. [PMC free article] [PubMed]
  • Wakasugi N. A genetically determined incompatibility system between spermatozoa and eggs leading to embryonic death in mice. J Reprod Fertil. 1974 Nov;41(1):85–96. [PubMed]
  • Pardo-Manuel de Villena F, Sapienza C. Genetic mapping of DXYMov15-associated sequences in the pseudoautosomal region of the C57BL/6J strain. Mamm Genome. 1996 Mar;7(3):237–239. [PubMed]
  • Wakasugi N, Tomita T, Kondo K. Differences of fertility in reciprocal crosses between inbred strains of mice. DDK, KK and NC. J Reprod Fertil. 1967 Feb;13(1):41–50. [PubMed]
  • Pardo-Manual de Villena F, Slamka C, Fonseca M, Naumova AK, Paquette J, Pannunzio P, Smith M, Verner A, Morgan K, Sapienza C. Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome. Genetics. 1996 Apr;142(4):1299–1304. [PMC free article] [PubMed]
  • Zechner U, Reule M, Orth A, Bonhomme F, Strack B, Guénet, Hameister H, Fundele R. An X-chromosome linked locus contributes to abnormal placental development in mouse interspecific hybrid. Nat Genet. 1996 Apr;12(4):398–403. [PubMed]
  • Pardo-Manual de Villena F, Slamka C, Fonseca M, Naumova AK, Paquette J, Pannunzio P, Smith M, Verner A, Morgan K, Sapienza C. Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome. Genetics. 1996 Apr;142(4):1299–1304. [PMC free article] [PubMed]
  • Zechner U, Reule M, Burgoyne PS, Schubert A, Orth A, Hameister H, Fundele R. Paternal transmission of X-linked placental dysplasia in mouse interspecific hybrids. Genetics. 1997 Aug;146(4):1399–1405. [PMC free article] [PubMed]
  • Pardo-Manuel de Villena F, Naumova AK, Verner AE, Jin WH, Sapienza C. Confirmation of maternal transmission ratio distortion at Om and direct evidence that the maternal and paternal "DDK syndrome" genes are linked. Mamm Genome. 1997 Sep;8(9):642–646. [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Gene
    Gene
    Gene links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • UniSTS
    UniSTS
    Related UniSTS records

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...