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Genetics. Jan 2000; 154(1): 333–342.
PMCID: PMC1460926

A genetic test to determine the origin of maternal transmission ratio distortion. Meiotic drive at the mouse Om locus.

Abstract

We have shown previously that the progeny of crosses between heterozygous females and C57BL/6 males show transmission ratio distortion at the Om locus on mouse chromosome 11. This result has been replicated in several independent experiments. Here we show that the distortion maps to a single locus on chromosome 11, closely linked to Om, and that gene conversion is not implicated in the origin of this phenomenon. To further investigate the origin of the transmission ratio distortion we generated a test using the well-known effect of recombination on maternal meiotic drive. The genetic test presented here discriminates between unequal segregation of alleles during meiosis and lethality, based on the analysis of genotype at both the distorted locus and the centromere of the same chromosome. We used this test to determine the cause of the transmission ratio distortion observed at the Om locus. Our results indicate that transmission ratio distortion at Om is due to unequal segregation of alleles to the polar body at the second meiotic division. Because the presence of segregation distortion at Om also depends on the genotype of the sire, our results confirm that the sperm can influence segregation of maternal chromosomes to the second polar body.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Evans K, Fryer A, Inglehearn C, Duvall-Young J, Whittaker JL, Gregory CY, Butler R, Ebenezer N, Hunt DM, Bhattacharya S. Genetic linkage of cone-rod retinal dystrophy to chromosome 19q and evidence for segregation distortion. Nat Genet. 1994 Feb;6(2):210–213. [PubMed]
  • Johnson KR, Cook SA, Davisson MT. Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse. Mamm Genome. 1994 Nov;5(11):670–687. [PubMed]
  • Justice MJ, Siracusa LD, Gilbert DJ, Heisterkamp N, Groffen J, Chada K, Silan CM, Copeland NG, Jenkins NA. A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross. Genetics. 1990 Aug;125(4):855–866. [PMC free article] [PubMed]
  • Agulnik SI, Agulnik AI, Ruvinsky AO. Meiotic drive in female mice heterozygous for the HSR inserts on chromosome 1. Genet Res. 1990 Apr;55(2):97–100. [PubMed]
  • Kaszás E, Birchler JA. Meiotic transmission rates correlate with physical features of rearranged centromeres in maize. Genetics. 1998 Dec;150(4):1683–1692. [PMC free article] [PubMed]
  • Agulnik SI, Sabantsev ID, Ruvinsky AO. Effect of sperm genotype on chromatid segregation in female mice heterozygous for aberrant chromosome 1. Genet Res. 1993 Apr;61(2):97–100. [PubMed]
  • Magee AC, Hughes AE. Segregation distortion in myotonic dystrophy. J Med Genet. 1998 Dec;35(12):1045–1046. [PMC free article] [PubMed]
  • Babinet C, Richoux V, Guénet JL, Renard JP. The DDK inbred strain as a model for the study of interactions between parental genomes and egg cytoplasm in mouse preimplantation development. Dev Suppl. 1990:81–87. [PubMed]
  • Mann JR. DDK egg-foreign sperm incompatibility in mice is not between the pronuclei. J Reprod Fertil. 1986 Mar;76(2):779–781. [PubMed]
  • Merrill C, Bayraktaroglu L, Kusano A, Ganetzky B. Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila. Science. 1999 Mar 12;283(5408):1742–1745. [PubMed]
  • Baldacci PA, Richoux V, Renard JP, Guénet JL, Babinet C. The locus Om, responsible for the DDK syndrome, maps close to Sigje on mouse chromosome 11. Mamm Genome. 1992;2(2):100–105. [PubMed]
  • Montagutelli X, Turner R, Nadeau JH. Epistatic control of non-Mendelian inheritance in mouse interspecific crosses. Genetics. 1996 Aug;143(4):1739–1752. [PMC free article] [PubMed]
  • Baldacci PA, Cohen-Tannoudji M, Kress C, Pournin S, Babinet C. A high-resolution map around the locus Om on mouse Chromosome 11. Mamm Genome. 1996 Feb;7(2):114–116. [PubMed]
  • Montgomery JC, Silverman KA, Buchberg AM. Encyclopedia of the mouse genome VII. Mouse chromosome 11. Mamm Genome. 1998;8(Spec No):S215–S240. [PubMed]
  • Biddle FG. Segregation distortion of X-linked marker genes in interspecific crosses between Mus musculus and M. spretus. Genome. 1987 Apr;29(2):389–392. [PubMed]
  • Canham RP, Birdsall DA, Cameron DG. Disturbed segregation at the transferrin locus of the deer mouse. Genet Res. 1970 Dec;16(3):355–357. [PubMed]
  • Naumova AK, Leppert M, Barker DF, Morgan K, Sapienza C. Parental origin-dependent, male offspring-specific transmission-ratio distortion at loci on the human X chromosome. Am J Hum Genet. 1998 Jun;62(6):1493–1499. [PMC free article] [PubMed]
  • Ceci JD, Siracusa LD, Jenkins NA, Copeland NG. A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes. Genomics. 1989 Nov;5(4):699–709. [PubMed]
  • Nur U. Maintenance of a "Parasitic" B Chromosome in the Grasshopper MELANOPLUS FEMUR-RUBRUM. Genetics. 1977 Nov;87(3):499–512. [PMC free article] [PubMed]
  • Pardo-Manual de Villena F, Slamka C, Fonseca M, Naumova AK, Paquette J, Pannunzio P, Smith M, Verner A, Morgan K, Sapienza C. Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome. Genetics. 1996 Apr;142(4):1299–1304. [PMC free article] [PubMed]
  • Chakraborty R, Stivers DN, Deka R, Yu LM, Shriver MD, Ferrell RE. Segregation distortion of the CTG repeats at the myotonic dystrophy locus. Am J Hum Genet. 1996 Jul;59(1):109–118. [PMC free article] [PubMed]
  • Pardo-Manuel de Villena F, Naumova AK, Verner AE, Jin WH, Sapienza C. Confirmation of maternal transmission ratio distortion at Om and direct evidence that the maternal and paternal "DDK syndrome" genes are linked. Mamm Genome. 1997 Sep;8(9):642–646. [PubMed]
  • Crow JF. Unmasking a cheating gene. Science. 1999 Mar 12;283(5408):1651–1652. [PubMed]
  • Pardo-Manuel de Villena F, de la Casa-Esperón E, Verner A, Morgan K, Sapienza C. The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om. Mamm Genome. 1999 May;10(5):492–497. [PubMed]
  • Dawe RK, Cande WZ. Induction of centromeric activity in maize by suppressor of meiotic drive 1. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8512–8517. [PMC free article] [PubMed]
  • de la Casa-Esperon E, Pardo-Manuel de Villena F, Verner AE, Briscoe TL, Malette JM, Rosa M, Jin WH, Sapienza C. Sex-of-offspring-specific transmission ratio distortion on mouse chromosome X. Genetics. 2000 Jan;154(1):343–350. [PMC free article] [PubMed]
  • Dietrich WF, Miller JC, Steen RG, Merchant M, Damron D, Nahf R, Gross A, Joyce DC, Wessel M, Dredge RD, et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nat Genet. 1994 Jun;7(2 Spec No):220–245. [PubMed]
  • Eaves IA, Bennett ST, Forster P, Ferber KM, Ehrmann D, Wilson AJ, Bhattacharyya S, Ziegler AG, Brinkmann B, Todd JA. Transmission ratio distortion at the INS-IGF2 VNTR. Nat Genet. 1999 Aug;22(4):324–325. [PubMed]
  • Renard JP, Babinet C. Identification of a paternal developmental effect on the cytoplasm of one-cell-stage mouse embryos. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6883–6886. [PMC free article] [PubMed]
  • Rhoades MM. Preferential Segregation in Maize. Genetics. 1942 Jul;27(4):395–407. [PMC free article] [PubMed]
  • Rhoades MM, Dempsey E. The Effect of Abnormal Chromosome 10 on Preferential Segregation and Crossing over in Maize. Genetics. 1966 May;53(5):989–1020. [PMC free article] [PubMed]
  • Rhoades MM, Vilkomerson H. On the Anaphase Movement of Chromosomes. Proc Natl Acad Sci U S A. 1942 Oct;28(10):433–436. [PMC free article] [PubMed]
  • Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MS, Thurston SJ, Birkenmeier EH. Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm Genome. 1994 May;5(5):253–274. [PubMed]
  • Rubinsztein DC, Leggo J. Non-Mendelian transmission at the Machado-Joseph disease locus in normal females: preferential transmission of alleles with smaller CAG repeats. J Med Genet. 1997 Mar;34(3):234–236. [PMC free article] [PubMed]
  • Ruvinsky A. Meiotic drive in female mice: an essay. Mamm Genome. 1995 May;6(5):315–320. [PubMed]
  • Ruvinsky AO, Agulnik SI, Agulnik AI, Belyaev DK. The influence of mutations on chromosome 17 upon the segregation of homologues in female mice heterozygous for Robertsonian translocations. Genet Res. 1987 Dec;50(3):235–237. [PubMed]
  • Sapienza C, Paquette J, Pannunzio P, Albrechtson S, Morgan K. The polar-lethal Ovum mutant gene maps to the distal portion of mouse chromosome 11. Genetics. 1992 Sep;132(1):241–246. [PMC free article] [PubMed]
  • Shendure J, Melo JA, Pociask K, Derr R, Silver LM. Sex-restricted non-Mendelian inheritance of mouse chromosome 11 in the offspring of crosses between C57BL/6J and (C57BL/6J x DBA/2J)F1 mice. Mamm Genome. 1998 Oct;9(10):812–815. [PubMed]
  • Silver LM. The peculiar journey of a selfish chromosome: mouse t haplotypes and meiotic drive. Trends Genet. 1993 Jul;9(7):250–254. [PubMed]
  • Siracusa LD, Alvord WG, Bickmore WA, Jenkins NA, Copeland NG. Interspecific backcross mice show sex-specific differences in allelic inheritance. Genetics. 1991 Aug;128(4):813–821. [PMC free article] [PubMed]
  • Vongs A, Kakutani T, Martienssen RA, Richards EJ. Arabidopsis thaliana DNA methylation mutants. Science. 1993 Jun 25;260(5116):1926–1928. [PubMed]
  • Vorechovský I, Webster AD, Plebani A, Hammarström L. Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition. Am J Hum Genet. 1999 Apr;64(4):1096–1109. [PMC free article] [PubMed]
  • Wakasugi N. Studies on fertility of DDK mice: reciprocal crosses between DDK and C57BL/6J strains and experimental transplantation of the ovary. J Reprod Fertil. 1973 May;33(2):283–291. [PubMed]
  • Wakasugi N, Tomita T, Kondo K. Differences of fertility in reciprocal crosses between inbred strains of mice. DDK, KK and NC. J Reprod Fertil. 1967 Feb;13(1):41–50. [PubMed]
  • Weinstein A. The Theory of Multiple-Strand Crossing over. Genetics. 1936 May;21(3):155–199. [PMC free article] [PubMed]
  • Yu HG, Hiatt EN, Chan A, Sweeney M, Dawe RK. Neocentromere-mediated chromosome movement in maize. J Cell Biol. 1997 Nov 17;139(4):831–840. [PMC free article] [PubMed]
  • Zhao H, McPeek MS, Speed TP. Statistical analysis of chromatid interference. Genetics. 1995 Feb;139(2):1057–1065. [PMC free article] [PubMed]

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