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Nucleic Acids Res. 1996 Jan 1; 24(1): 32–39.
PMCID: PMC145574

EcoCyc: an encyclopedia of Escherichia coli genes and metabolism.


The encyclopedia of Escherichia coli genes and metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of E.coli. It describes 2034 genes, 306 enzymes encoded by these genes, 580 metabolic reactions that occur in E.coli and the organization of these reactions into 100 metabolic pathways. The EcoCyc graphical user interface allows query and exploration of the EcoCyc database using visualization tools such as genomic map browsers and automatic layouts of metabolic pathways. EcoCyc spans the space from sequence to function to allow investigation of an unusually broad range of questions. EcoCyc can be thought of as both an electronic review article, because of its copious references to the primary literature, and as an in silico model of E.coli that can be probed and analyzed through computational means.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Riley M. Functions of the gene products of Escherichia coli. Microbiol Rev. 1993 Dec;57(4):862–952. [PMC free article] [PubMed]
  • Karp PD. A knowledge base of the chemical compounds of intermediary metabolism. Comput Appl Biosci. 1992 Aug;8(4):347–357. [PubMed]
  • Bairoch A. The ENZYME data bank. Nucleic Acids Res. 1994 Sep;22(17):3626–3627. [PMC free article] [PubMed]

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