• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of plntcellLink to Publisher's site
Plant Cell. Dec 1999; 11(12): 2271–2281.
PMCID: PMC144146

Ten years of enhancer detection: lessons from the fly.

Full Text

The Full Text of this article is available as a PDF (110K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Aarts MG, Dirkse WG, Stiekema WJ, Pereira A. Transposon tagging of a male sterility gene in Arabidopsis. Nature. 1993 Jun 24;363(6431):715–717. [PubMed]
  • Bancroft I, Dean C. Transposition pattern of the maize element Ds in Arabidopsis thaliana. Genetics. 1993 Aug;134(4):1221–1229. [PMC free article] [PubMed]
  • Bellen HJ, O'Kane CJ, Wilson C, Grossniklaus U, Pearson RK, Gehring WJ. P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev. 1989 Sep;3(9):1288–1300. [PubMed]
  • Bellen HJ, Kooyer S, D'Evelyn D, Pearlman J. The Drosophila couch potato protein is expressed in nuclei of peripheral neuronal precursors and shows homology to RNA-binding proteins. Genes Dev. 1992 Nov;6(11):2125–2136. [PubMed]
  • Bellen HJ, Vaessin H, Bier E, Kolodkin A, D'Evelyn D, Kooyer S, Jan YN. The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics. 1992 Jun;131(2):365–375. [PMC free article] [PubMed]
  • Bhat MA, Izaddoost S, Lu Y, Cho KO, Choi KW, Bellen HJ. Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell. 1999 Mar 19;96(6):833–845. [PubMed]
  • Bier E, Vaessin H, Shepherd S, Lee K, McCall K, Barbel S, Ackerman L, Carretto R, Uemura T, Grell E, et al. Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. Genes Dev. 1989 Sep;3(9):1273–1287. [PubMed]
  • Brand AH, Dormand EL. The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system. Curr Opin Neurobiol. 1995 Oct;5(5):572–578. [PubMed]
  • Brand AH, Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 1993 Jun;118(2):401–415. [PubMed]
  • Braun A, Lemaitre B, Lanot R, Zachary D, Meister M. Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap. Genetics. 1997 Oct;147(2):623–634. [PMC free article] [PubMed]
  • Brook WJ, Ostafichuk LM, Piorecky J, Wilkinson MD, Hodgetts DJ, Russell MA. Gene expression during imaginal disc regeneration detected using enhancer-sensitive P-elements. Development. 1993 Apr;117(4):1287–1297. [PubMed]
  • Callahan CA, Thomas JB. Tau-beta-galactosidase, an axon-targeted fusion protein. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5972–5976. [PMC free article] [PubMed]
  • Calleja M, Moreno E, Pelaz S, Morata G. Visualization of gene expression in living adult Drosophila. Science. 1996 Oct 11;274(5285):252–255. [PubMed]
  • Casadaban MJ, Cohen SN. Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage: in vivo probe for transcriptional control sequences. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4530–4533. [PMC free article] [PubMed]
  • Casares F, Bender W, Merriam J, Sánchez-Herrero E. Interactions of Drosophila Ultrabithorax regulatory regions with native and foreign promoters. Genetics. 1997 Jan;145(1):123–137. [PMC free article] [PubMed]
  • Chang Z, Price BD, Bockheim S, Boedigheimer MJ, Smith R, Laughon A. Molecular and genetic characterization of the Drosophila tartan gene. Dev Biol. 1993 Dec;160(2):315–332. [PubMed]
  • Cooley L, Kelley R, Spradling A. Insertional mutagenesis of the Drosophila genome with single P elements. Science. 1988 Mar 4;239(4844):1121–1128. [PubMed]
  • Corces VG, Geyer PK. Interactions of retrotransposons with the host genome: the case of the gypsy element of Drosophila. Trends Genet. 1991 Mar;7(3):86–90. [PubMed]
  • Datta S, Stark K, Kankel DR. Enhancer detector analysis of the extent of genomic involvement in nervous system development in Drosophila melanogaster. J Neurobiol. 1993 Jun;24(6):824–841. [PubMed]
  • Davis RL, Han KA. Neuroanatomy: mushrooming mushroom bodies. Curr Biol. 1996 Feb 1;6(2):146–148. [PubMed]
  • Deák P, Omar MM, Saunders RD, Pál M, Komonyi O, Szidonya J, Maróy P, Zhang Y, Ashburner M, Benos P, et al. P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. Genetics. 1997 Dec;147(4):1697–1722. [PMC free article] [PubMed]
  • Dye CA, Lee JK, Atkinson RC, Brewster R, Han PL, Bellen HJ. The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein. Development. 1998 May;125(10):1845–1856. [PubMed]
  • Eldon E, Kooyer S, D'Evelyn D, Duman M, Lawinger P, Botas J, Bellen H. The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. Development. 1994 Apr;120(4):885–899. [PubMed]
  • Forjanic JP, Chen CK, Jäckle H, González Gaitán M. Genetic analysis of stomatogastric nervous system development in Drosophila using enhancer trap lines. Dev Biol. 1997 Jun 15;186(2):139–154. [PubMed]
  • Friedrich G, Soriano P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513–1523. [PubMed]
  • Gaul U, Mardon G, Rubin GM. A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell. 1992 Mar 20;68(6):1007–1019. [PubMed]
  • Ghysen A, O'Kane C. Neural enhancer-like elements as specific cell markers in Drosophila. Development. 1989 Jan;105(1):35–52. [PubMed]
  • Gönczy P, Viswanathan S, DiNardo S. Probing spermatogenesis in Drosophila with P-element enhancer detectors. Development. 1992 Jan;114(1):89–98. [PubMed]
  • Gossler A, Joyner AL, Rossant J, Skarnes WC. Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science. 1989 Apr 28;244(4903):463–465. [PubMed]
  • Grossniklaus U, Bellen HJ, Wilson C, Gehring WJ. P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila. Development. 1989 Oct;107(2):189–200. [PubMed]
  • Grossniklaus U, Pearson RK, Gehring WJ. The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes Dev. 1992 Jun;6(6):1030–1051. [PubMed]
  • Grotewiel MS, Beck CD, Wu KH, Zhu XR, Davis RL. Integrin-mediated short-term memory in Drosophila. Nature. 1998 Jan 29;391(6666):455–460. [PubMed]
  • Gu Q, Ferrándiz C, Yanofsky MF, Martienssen R. The FRUITFULL MADS-box gene mediates cell differentiation during Arabidopsis fruit development. Development. 1998 Apr;125(8):1509–1517. [PubMed]
  • Gustafson K, Boulianne GL. Distinct expression patterns detected within individual tissues by the GAL4 enhancer trap technique. Genome. 1996 Feb;39(1):174–182. [PubMed]
  • Harrison DA, Gdula DA, Coyne RS, Corces VG. A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function. Genes Dev. 1993 Oct;7(10):1966–1978. [PubMed]
  • Hidalgo A, Brand AH. Targeted neuronal ablation: the role of pioneer neurons in guidance and fasciculation in the CNS of Drosophila. Development. 1997 Sep;124(17):3253–3262. [PubMed]
  • Holdridge C, Dorsett D. Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster. Mol Cell Biol. 1991 Apr;11(4):1894–1900. [PMC free article] [PubMed]
  • Hope IA. 'Promoter trapping' in Caenorhabditis elegans. Development. 1991 Oct;113(2):399–408. [PubMed]
  • Hope IA, Albertson DG, Martinelli SD, Lynch AS, Sonnhammer E, Durbin R. The C. elegans expression pattern database: a beginning. Trends Genet. 1996 Sep;12(9):370–371. [PubMed]
  • Hoshizaki DK, Lunz R, Ghosh M, Johnson W. Identification of fat-cell enhancer activity in Drosophila melanogaster using P-element enhancer traps. Genome. 1995 Jun;38(3):497–506. [PubMed]
  • Ito K, Sass H, Urban J, Hofbauer A, Schneuwly S. GAL4-responsive UAS-tau as a tool for studying the anatomy and development of the Drosophila central nervous system. Cell Tissue Res. 1997 Oct;290(1):1–10. [PubMed]
  • Kania A, Han PL, Kim YT, Bellen H. Neuromusculin, a Drosophila gene expressed in peripheral neuronal precursors and muscles, encodes a cell adhesion molecule. Neuron. 1993 Oct;11(4):673–687. [PubMed]
  • Kania A, Salzberg A, Bhat M, D'Evelyn D, He Y, Kiss I, Bellen HJ. P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. Genetics. 1995 Apr;139(4):1663–1678. [PMC free article] [PubMed]
  • Kerr WG, Nolan GP, Serafini AT, Herzenberg LA. Transcriptionally defective retroviruses containing lacZ for the in situ detection of endogenous genes and developmentally regulated chromatin. Cold Spring Harb Symp Quant Biol. 1989;54(Pt 2):767–776. [PubMed]
  • Klämbt C, Jacobs JR, Goodman CS. The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance. Cell. 1991 Feb 22;64(4):801–815. [PubMed]
  • Klimyuk VI, Nussaume L, Harrison K, Jones JD. Novel GUS expression patterns following transposition of an enhancer trap Ds element in Arabidopsis. Mol Gen Genet. 1995 Dec 10;249(4):357–365. [PubMed]
  • Kunes S, Steller H. Ablation of Drosophila photoreceptor cells by conditional expression of a toxin gene. Genes Dev. 1991 Jun;5(6):970–983. [PubMed]
  • Littleton JT, Stern M, Schulze K, Perin M, Bellen HJ. Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release. Cell. 1993 Sep 24;74(6):1125–1134. [PubMed]
  • Lloyd AM, Walbot V, Davis RW. Arabidopsis and Nicotiana anthocyanin production activated by maize regulators R and C1. Science. 1992 Dec 11;258(5089):1773–1775. [PubMed]
  • Long D, Martin M, Sundberg E, Swinburne J, Puangsomlee P, Coupland G. The maize transposable element system Ac/Ds as a mutagen in Arabidopsis: identification of an albino mutation induced by Ds insertion. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10370–10374. [PMC free article] [PubMed]
  • Lynch AS, Briggs D, Hope IA. Developmental expression pattern screen for genes predicted in the C. elegans genome sequencing project. Nat Genet. 1995 Nov;11(3):309–313. [PubMed]
  • Manseau L, Baradaran A, Brower D, Budhu A, Elefant F, Phan H, Philp AV, Yang M, Glover D, Kaiser K, et al. GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of Drosophila. Dev Dyn. 1997 Jul;209(3):310–322. [PubMed]
  • McCall K, O'Connor MB, Bender W. Enhancer traps in the Drosophila bithorax complex mark parasegmental domains. Genetics. 1994 Oct;138(2):387–399. [PMC free article] [PubMed]
  • Moffat KG, Gould JH, Smith HK, O'Kane CJ. Inducible cell ablation in Drosophila by cold-sensitive ricin A chain. Development. 1992 Mar;114(3):681–687. [PubMed]
  • O'Kane CJ, Gehring WJ. Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9123–9127. [PMC free article] [PubMed]
  • O'Kane C, Stephens MA, McConnell D. Integrable alpha-amylase plasmid for generating random transcriptional fusions in Bacillus subtilis. J Bacteriol. 1986 Nov;168(2):973–981. [PMC free article] [PubMed]
  • Parinov S, Sevugan M, Ye D, Yang WC, Kumaran M, Sundaresan V. Analysis of flanking sequences from dissociation insertion lines: a database for reverse genetics in Arabidopsis. Plant Cell. 1999 Dec;11(12):2263–2270. [PMC free article] [PubMed]
  • Perrimon N, Noll E, McCall K, Brand A. Generating lineage-specific markers to study Drosophila development. Dev Genet. 1991;12(3):238–252. [PubMed]
  • Phelps CB, Brand AH. Ectopic gene expression in Drosophila using GAL4 system. Methods. 1998 Apr;14(4):367–379. [PubMed]
  • Pignoni F, Hu B, Zipursky SL. Identification of genes required for Drosophila eye development using a phenotypic enhancer-trap. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9220–9225. [PMC free article] [PubMed]
  • Robertson HM, Preston CR, Phillis RW, Johnson-Schlitz DM, Benz WK, Engels WR. A stable genomic source of P element transposase in Drosophila melanogaster. Genetics. 1988 Mar;118(3):461–470. [PMC free article] [PubMed]
  • Rodriguez A, Zhou Z, Tang ML, Meller S, Chen J, Bellen H, Kimbrell DA. Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics. 1996 Jun;143(2):929–940. [PMC free article] [PubMed]
  • Rørth P. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12418–12422. [PMC free article] [PubMed]
  • Rørth P, Szabo K, Bailey A, Laverty T, Rehm J, Rubin GM, Weigmann K, Milán M, Benes V, Ansorge W, et al. Systematic gain-of-function genetics in Drosophila. Development. 1998 Mar;125(6):1049–1057. [PubMed]
  • Roseman RR, Pirrotta V, Geyer PK. The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects. EMBO J. 1993 Feb;12(2):435–442. [PMC free article] [PubMed]
  • Roseman RR, Johnson EA, Rodesch CK, Bjerke M, Nagoshi RN, Geyer PK. A P element containing suppressor of hairy-wing binding regions has novel properties for mutagenesis in Drosophila melanogaster. Genetics. 1995 Nov;141(3):1061–1074. [PMC free article] [PubMed]
  • Rossant J, Hopkins N. Of fin and fur: mutational analysis of vertebrate embryonic development. Genes Dev. 1992 Jan;6(1):1–13. [PubMed]
  • Salzberg A, D'Evelyn D, Schulze KL, Lee JK, Strumpf D, Tsai L, Bellen HJ. Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron. 1994 Aug;13(2):269–287. [PubMed]
  • Salzberg A, Prokopenko SN, He Y, Tsai P, Pál M, Maróy P, Glover DM, Deák P, Bellen HJ. P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development. Genetics. 1997 Dec;147(4):1723–1741. [PMC free article] [PubMed]
  • Samakovlis C, Hacohen N, Manning G, Sutherland DC, Guillemin K, Krasnow MA. Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development. 1996 May;122(5):1395–1407. [PubMed]
  • Segal D, Cherbas L, Cherbas P. Genetic transformation of Drosophila cells in culture by P element-mediated transposition. Somat Cell Mol Genet. 1996 Mar;22(2):159–165. [PubMed]
  • Sepp KJ, Auld VJ. Conversion of lacZ enhancer trap lines to GAL4 lines using targeted transposition in Drosophila melanogaster. Genetics. 1999 Mar;151(3):1093–1101. [PMC free article] [PubMed]
  • Smith D, Wohlgemuth J, Calvi BR, Franklin I, Gelbart WM. hobo enhancer trapping mutagenesis in Drosophila reveals an insertion specificity different from P elements. Genetics. 1993 Dec;135(4):1063–1076. [PMC free article] [PubMed]
  • Spradling AC, Rubin GM. Transposition of cloned P elements into Drosophila germ line chromosomes. Science. 1982 Oct 22;218(4570):341–347. [PubMed]
  • Spradling AC, Stern DM, Kiss I, Roote J, Laverty T, Rubin GM. Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10824–10830. [PMC free article] [PubMed]
  • Spradling AC, Stern D, Beaton A, Rhem EJ, Laverty T, Mozden N, Misra S, Rubin GM. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics. 1999 Sep;153(1):135–177. [PMC free article] [PubMed]
  • Sundaresan V, Springer P, Volpe T, Haward S, Jones JD, Dean C, Ma H, Martienssen R. Patterns of gene action in plant development revealed by enhancer trap and gene trap transposable elements. Genes Dev. 1995 Jul 15;9(14):1797–1810. [PubMed]
  • Sweeney ST, Broadie K, Keane J, Niemann H, O'Kane CJ. Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Neuron. 1995 Feb;14(2):341–351. [PubMed]
  • Tissot M, Gendre N, Hawken A, Störtkuhl KF, Stocker RF. Larval chemosensory projections and invasion of adult afferents in the antennal lobe of Drosophila. J Neurobiol. 1997 Mar;32(3):281–297. [PubMed]
  • Török T, Tick G, Alvarado M, Kiss I. P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes. Genetics. 1993 Sep;135(1):71–80. [PMC free article] [PubMed]
  • Tower J, Karpen GH, Craig N, Spradling AC. Preferential transposition of Drosophila P elements to nearby chromosomal sites. Genetics. 1993 Feb;133(2):347–359. [PMC free article] [PubMed]
  • Wilson C, Pearson RK, Bellen HJ, O'Kane CJ, Grossniklaus U, Gehring WJ. P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev. 1989 Sep;3(9):1301–1313. [PubMed]
  • Wilson C, Bellen HJ, Gehring WJ. Position effects on eukaryotic gene expression. Annu Rev Cell Biol. 1990;6:679–714. [PubMed]
  • Zambrowicz BP, Friedrich GA, Buxton EC, Lilleberg SL, Person C, Sands AT. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608–611. [PubMed]
  • Zhang P, Spradling AC. Efficient and dispersed local P element transposition from Drosophila females. Genetics. 1993 Feb;133(2):361–373. [PMC free article] [PubMed]

Articles from The Plant Cell are provided here courtesy of American Society of Plant Biologists

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...