• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of gutGutView this articleSubmit a manuscriptReceive email alertsContact usBMJ
Gut. Nov 1988; 29(11): 1564–1568.
PMCID: PMC1433820

Low gluten diet in the treatment of adult coeliac disease: effect on jejunal morphology and serum anti-gluten antibodies.

Abstract

Treatment of patients with coeliac disease with a low gluten containing diet (LGD) remains controversial. We have studied jejunal morphology and antigluten (AG) antibody titres by ELISA in patients on a LGD of 2.5-5 g/day for three to 14 months (median six months) and compared results with patients on a strict gluten free diet (GFD) for six to 27 months (median 13 months). We found no significant difference in villous height or crypt depth (eight LGD v 10 GFD patients) or serum AG-IgA, -IgG, and IgM titres (13 LGD v 12 GFD patients). there was however, a significant increase (p less than 0.05) in intra-epithelial lymphocytes in those patients on a LGD. We conclude that adult coeliac patients can tolerate a LGD without gross morphological change and without initiating significant AG antibody responses.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (621K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Sheldon W. Prognosis in early adult life of coeliac children treated with a gluten-free diet. Br Med J. 1969 May 17;2(5654):401–404. [PMC free article] [PubMed]
  • Young WF, Pringle EM. 110 children with coeliac disease, 1950-1969. Arch Dis Child. 1971 Aug;46(248):421–436. [PMC free article] [PubMed]
  • Visakorpi JK, Kuitunen P, Savilahti E. Frequency and nature of relapses in children suffering from the malabsorption syndrome with gluten intolerance. Acta Paediatr Scand. 1970 Sep;59(5):481–486. [PubMed]
  • Baker PG, Barry RE, Read AE. Detection of continuing gluten ingestion in treated coeliac patients. Br Med J. 1975 Mar 1;1(5956):486–488. [PMC free article] [PubMed]
  • Jackson PT, Glasgow JF, Thom R. Parents' understanding of coeliac disease and diet. Arch Dis Child. 1985 Jul;60(7):672–674. [PMC free article] [PubMed]
  • Mattison DR, Thorgeirsson SS. Smoking and industrial pollution, and their effects on menopause and ovarian cancer. Lancet. 1978 Jan 28;1(8057):187–188. [PubMed]
  • Anderson CM, Gracey M, Burke V. Coeliac disease. Some still controversial aspects. Arch Dis Child. 1972 Apr;47(252):292–298. [PMC free article] [PubMed]
  • Ferguson A, Murray D. Quantitation of intraepithelial lymphocytes in human jejunum. Gut. 1971 Dec;12(12):988–994. [PMC free article] [PubMed]
  • Goka AK, Farthing MJ. The use of 3,3',5,5'-tetramethylbenzidine as a peroxidase substrate in microplate enzyme-linked immunosorbent assay. J Immunoassay. 1987;8(1):29–41. [PubMed]
  • Unsworth DJ, Kieffer M, Holborow EJ, Coombs RR, Walker-Smith JA. IgA anti-gliadin antibodies in coeliac disease. Clin Exp Immunol. 1981 Nov;46(2):286–293. [PMC free article] [PubMed]
  • Eterman KP, Feltkamp TE. Antibodies to gluten and reticulin in gastrointestinal diseases. Clin Exp Immunol. 1978 Jan;31(1):92–99. [PMC free article] [PubMed]
  • Friis SU, Gudmand-Høyer E. Screening for coeliac disease in adults by simultaneous determination of IgA and IgG gliadin antibodies. Scand J Gastroenterol. 1986 Nov;21(9):1058–1062. [PubMed]
  • O'Farrelly C, Kelly J, Hekkens W, Bradley B, Thompson A, Feighery C, Weir DG. Alpha gliadin antibody levels: a serological test for coeliac disease. Br Med J (Clin Res Ed) 1983 Jun 25;286(6383):2007–2010. [PMC free article] [PubMed]
  • Juto P, Fredrikzon B, Hernell O. Gliadin-specific serum immunoglobulins A, E, G, and M in childhood: relation to small intestine mucosal morphology. J Pediatr Gastroenterol Nutr. 1985 Oct;4(5):723–729. [PubMed]
  • Kieffer M, Frazier PJ, Daniels NW, Coombs RR. Wheat gliadin fractions and other cereal antigens reactive with antibodies in the sera of coeliac patients. Clin Exp Immunol. 1982 Dec;50(3):651–660. [PMC free article] [PubMed]
  • Ciclitira PJ, Ellis HJ, Richards D, Kemeny DM. Gliadin IgG subclass antibodies in patients with coeliac disease. Int Arch Allergy Appl Immunol. 1986;80(3):258–261. [PubMed]
  • Gliadin antibody levels in screening tests for coeliac disease. Br Med J (Clin Res Ed) 1984 Jan 7;288(6410):69–71. [PMC free article] [PubMed]
  • Volta U, Lenzi M, Lazzari R, Cassani F, Collina A, Bianchi FB, Pisi E. Antibodies to gliadin detected by immunofluorescence and a micro-ELISA method: markers of active childhood and adult coeliac disease. Gut. 1985 Jul;26(7):667–671. [PMC free article] [PubMed]
  • Scott H, Ek J, Brandtzaeg P. Changes of serum antibody activities to various dietary antigens related to gluten withdrawal or challenge in children with coeliac disease. Int Arch Allergy Appl Immunol. 1985;76(2):138–144. [PubMed]
  • Savilahti E, Viander M, Perkkiö M, Vainio E, Kalimo K, Reunala T. IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease. Lancet. 1983 Feb 12;1(8320):320–322. [PubMed]
  • Hamilton JR, McNeill LK. Childhood celiac disease: response of treated patients to a small uniform daily dose of wheat gluten. J Pediatr. 1972 Nov;81(5):885–893. [PubMed]
  • Kumar PJ, O'Donoghue DP, Stenson K, Dawson AM. Reintroduction of gluten in adults and children with treated coeliac disease. Gut. 1979 Sep;20(9):743–749. [PMC free article] [PubMed]
  • Leigh RJ, Marsh MN, Crowe P, Kelly C, Garner V, Gordon D. Studies of intestinal lymphoid tissue. IX. Dose-dependent, gluten-induced lymphoid infiltration of coeliac jejunal epithelium. Scand J Gastroenterol. 1985 Aug;20(6):715–719. [PubMed]

Articles from Gut are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...