• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of gutGutCurrent TOCInstructions to authors
Gut. Jul 1988; 29(7): 926–929.
PMCID: PMC1433759

Allopurinol attenuates caerulein induced acute pancreatitis in the rat.

Abstract

Oxygen derived free radicals have been implicated in the pathogenesis of acute pancreatitis in numerous animal models of the disease. The xanthine oxidase inhibitor allopurinol has been shown to attenuate pancreatic damage in canine and mouse models of acute pancreatitis presumably by preventing the generation of cytotoxic superoxide anions. We therefore examined whether allopurinol could attenuate pancreatic injury in conscious rats with caerulein induced acute pancreatitis. A continuous intravenous infusion of allopurinol (20 mg/kg/h) for six hours along with an acute pancreatitis producing dose of caerulein (10 micrograms/kg/h) reduced pancreas weights by approximately 45% and serum amylase concentrations by approximately 60% compared with rats intravenously infused with either caerulein alone or caerulein plus a lower dose (10 mg/kg/h) of allopurinol. We conclude that the generation of oxygen derived free radicals via pancreatic xanthine oxidase represents an early and perhaps pivotal mechanism in the pathogenesis of acute pancreatitis.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (608K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Sanfey H, Sarr MG, Bulkley GB, Cameron JL. Oxygen-derived free radicals and acute pancreatitis: a review. Acta Physiol Scand Suppl. 1986;548:109–118. [PubMed]
  • Sanfey H, Bulkley GB, Cameron JL. The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Ann Surg. 1984 Oct;200(4):405–413. [PMC free article] [PubMed]
  • Sanfey H, Bulkley GB, Cameron JL. The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models. Ann Surg. 1985 May;201(5):633–639. [PMC free article] [PubMed]
  • Rutledge PL, Saluja AK, Powers RE, Steer ML. Role of oxygen-derived free radicals in diet-induced hemorrhagic pancreatitis in mice. Gastroenterology. 1987 Jul;93(1):41–47. [PubMed]
  • Lampel M, Kern HF. Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch A Pathol Anat Histol. 1977 Mar 11;373(2):97–117. [PubMed]
  • Adler G, Rohr G, Kern HF. Alteration of membrane fusion as a cause of acute pancreatitis in the rat. Dig Dis Sci. 1982 Nov;27(11):993–1002. [PubMed]
  • Renner IG, Wisner JR, Jr, Rinderknecht H. Protective effects of exogenous secretin on ceruletide-induced acute pancreatitis in the rat. J Clin Invest. 1983 Sep;72(3):1081–1092. [PMC free article] [PubMed]
  • Watanabe O, Baccino FM, Steer ML, Meldolesi J. Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol. 1984 Apr;246(4 Pt 1):G457–G467. [PubMed]
  • Steer ML, Meldolesi J, Figarella C. Pancreatitis. The role of lysosomes. Dig Dis Sci. 1984 Oct;29(10):934–938. [PubMed]
  • Niederau C, Ferrell LD, Grendell JH. Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology. 1985 May;88(5 Pt 1):1192–1204. [PubMed]
  • Renner IG, Wisner JR, Jr, Lavigne BC. Partial restoration of pancreatic function by exogenous secretin in rats with ceruletide-induced acute pancreatitis. Dig Dis Sci. 1986 Mar;31(3):305–313. [PubMed]
  • Wisner JR, Jr, Renner IG, Grendell JH, Niederau C, Ferrell LD. Gabexate mesilate (FOY) protects against ceruletide-induced acute pancreatitis in the rat. Pancreas. 1987;2(2):181–186. [PubMed]
  • Sarr MG, Bulkley GB, Cameron JL. Temporal efficacy of allopurinol during the induction of pancreatitis in the ex vivo perfused canine pancreas. Surgery. 1987 Mar;101(3):342–346. [PubMed]
  • McCord JM, Roy RS. The pathophysiology of superoxide: roles in inflammation and ischemia. Can J Physiol Pharmacol. 1982 Nov;60(11):1346–1352. [PubMed]
  • Parks DA, Bulkley GB, Granger DN. Role of oxygen-derived free radicals in digestive tract diseases. Surgery. 1983 Sep;94(3):415–422. [PubMed]
  • Slater TF. Free-radical mechanisms in tissue injury. Biochem J. 1984 Aug 15;222(1):1–15. [PMC free article] [PubMed]
  • Proctor PH, Reynolds ES. Free radicals and disease in man. Physiol Chem Phys Med NMR. 1984;16(3):175–195. [PubMed]
  • Sarr MG, Bulkley GB, Cameron JL. The role of leukocytes in the production of oxygen-derived free radicals in acute experimental pancreatitis. Surgery. 1987 Mar;101(3):292–296. [PubMed]
  • Guice KS, Miller DE, Oldham KT, Townsend CM, Jr, Thompson JC. Superoxide dismutase and catalase: a possible role in established pancreatitis. Am J Surg. 1986 Jan;151(1):163–169. [PubMed]

Articles from Gut are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...