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Gut. Nov 1987; 28(11): 1510–1513.
PMCID: PMC1433676

Double blind study of ispaghula in irritable bowel syndrome.

Abstract

A double blind placebo controlled trial of ispaghula husk in 80 patients with irritable bowel syndrome is reported. Global assessment judged treatment to be satisfactory in 82% of patients receiving ispaghula and 53% of the placebo group (p less than 0.02). Bowel habit was unchanged in the placebo group, while constipation significantly improved in patients taking ispaghula (p = 0.026). Transit time decreased significantly in those taking ispaghula compared with placebo (p = 0.001), especially in patients with initially high transit times. Abdominal pain and bloating improved in both groups, with no significant differences between ispaghula and placebo. Four of the eight withdrawals on ispaghula and 10 of the 15 withdrawals on placebo were because of treatment failure. Ispaghula significantly improves overall well being in patients with irritable bowel syndrome, and in those with constipation favourably affects bowel habit and transit time.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Fielding JF. The irritable bowel syndrome. Part I: clinical spectrum. Clin Gastroenterol. 1977 Sep;6(3):607–622. [PubMed]
  • Thompson WG. The irritable bowel. Gut. 1984 Mar;25(3):305–320. [PMC free article] [PubMed]
  • Manning AP, Heaton KW, Harvey RF. Wheat fibre and irritable bowel syndrome. A controlled trial. Lancet. 1977 Aug 27;2(8035):417–418. [PubMed]
  • Ritchie JA, Truelove SC. Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide, and ispaghula husk. Br Med J. 1979 Feb 10;1(6160):376–378. [PMC free article] [PubMed]
  • Soltoft J, Krag B, Gudmand-Hoyer E, Kristensen E, Wulff HR. A double-blind trial of the effect of wheat bran on symptoms of irritable bowel syndrome. Lancet. 1976 Feb 7;1(7954):270–272. [PubMed]
  • Longstreth GF, Fox DD, Youkeles L, Forsythe AB, Wolochow DA. Psyllium therapy in the irritable bowel syndrome. A double-blind trial. Ann Intern Med. 1981 Jul;95(1):53–56. [PubMed]
  • Arthurs Y, Fielding JF. Double blind trial of ispaghula/poloxamer in the Irritable Bowel Syndrome. Ir Med J. 1983 May;76(5):253–253. [PubMed]
  • Cann PA, Read NW, Holdsworth CD. What is the benefit of coarse wheat bran in patients with irritable bowel syndrome? Gut. 1984 Feb;25(2):168–173. [PMC free article] [PubMed]
  • Arffmann S, Andersen JR, Hegnhøj J, Schaffalitzky de Muckadell OB, Mogensen NB, Krag E. The effect of coarse wheat bran in the irritable bowel syndrome. A double-blind cross-over study. Scand J Gastroenterol. 1985 Apr;20(3):295–298. [PubMed]
  • Hinton JM, Lennard-Jones JE, Young AC. A ne method for studying gut transit times using radioopaque markers. Gut. 1969 Oct;10(10):842–847. [PMC free article] [PubMed]
  • Whorwell PJ, McCallum M, Creed FH, Roberts CT. Non-colonic features of irritable bowel syndrome. Gut. 1986 Jan;27(1):37–40. [PMC free article] [PubMed]

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