Logo of gutGutView this articleSubmit a manuscriptReceive email alertsContact usBMJ
Gut. Jan 1988; 29(1): 49–56.
PMCID: PMC1433251

Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982.

Abstract

The overall age and sex adjusted incidence of Crohn's disease among Olmsted County, Minnesota, residents was 4.0 per 100,000 person-year in the period 1943-1982. Ileitis, ileocolitis, and colitis each accounted for about one third of the 103 incidence cases. Incidence rates were greater in woman than men, were higher in the urban portions of the county, and rose over time. Overall, the natural history of Crohn's disease in the community may be milder than that reported for patients at referral centres, as over half of all patients had no complications and only a third required surgery for Crohn's disease. Only one developed adenocarcinoma of the colon (relative risk = 2.0, NS). Survival was relatively unimpaired for the cohort, but Crohn's disease may have played a role in half of the deaths. The prevalence of Crohn's disease was 90.5/100,000 population on 1 January 1980.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Mendeloff AI. The epidemiology of inflammatory bowel disease. Clin Gastroenterol. 1980 May;9(2):259–270. [PubMed]
  • Gilat T. Incidence of inflammatory bowel disease: going up or down? Gastroenterology. 1983 Jul;85(1):196–197. [PubMed]
  • Sachar DB. Crohn's disease in Cleveland: a matter of life and death. Gastroenterology. 1985 Jun;88(6):1996–1998. [PubMed]
  • Kurland LT, Molgaard CA. The patient record in epidemiology. Sci Am. 1981 Oct;245(4):54–63. [PubMed]
  • Beart RW, Melton LJ, 3rd, Maruta M, Dockerty MB, Frydenberg HB, O'Fallon WM. Trends in right and left-sided colon cancer. Dis Colon Rectum. 1983 Jun;26(6):393–398. [PubMed]
  • Devlin HB, Datta D, Dellipiani AW. The incidence and prevalence of inflammatory bowel disease in North Tees Health District. World J Surg. 1980;4(2):183–193. [PubMed]
  • Lee FI, Costello FT. Crohn's disease in Blackpool--incidence and prevalence 1968-80. Gut. 1985 Mar;26(3):274–278. [PMC free article] [PubMed]
  • Mayberry J, Rhodes J, Hughes LE. Incidence of Crohn's disease in Cardiff between 1934-1977. Gut. 1979 Jul;20(7):602–608. [PMC free article] [PubMed]
  • Mayberry JF, Dew MJ, Morris JS, Powell DB. An audit of Crohn's disease in a defined population. J R Coll Physicians Lond. 1983 Jul;17(3):196–198. [PubMed]
  • Hellers G. Crohn's disease in Stockholm county 1955-1974. A study of epidemiology, results of surgical treatment and long-term prognosis. Acta Chir Scand Suppl. 1979;490:1–84. [PubMed]
  • Bergman L, Krause U. The incidence of Crohn's disease in central Sweden. Scand J Gastroenterol. 1975;10(7):725–729. [PubMed]
  • Brahme F, Lindström C, Wenckert A. Crohn's disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmö, Sweden. Gastroenterology. 1975 Aug;69(2):342–351. [PubMed]
  • Evans JG, Acheson ED. An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area. Gut. 1965 Aug;6(4):311–324. [PMC free article] [PubMed]
  • Kyle J, Stark G. Fall in the incidence of Crohn's disease. Gut. 1980 Apr;21(4):340–343. [PMC free article] [PubMed]
  • Fahrländer H, Baerlocher C. Clinical features and epidemiological data on Crohn's disease in the Basle area. Scand J Gastroenterol. 1971;6(7):657–662. [PubMed]
  • Binder V, Both H, Hansen PK, Hendriksen C, Kreiner S, Torp-Pedersen K. Incidence and prevalence of ulcerative colitis and Crohn's disease in the County of Copenhagen, 1962 to 1978. Gastroenterology. 1982 Sep;83(3):563–568. [PubMed]
  • Brandes JW, Lorenz-Meyer H. Epidemiologische Aspekte zur Enterocolitis regionalis Crohn und Colitis ulcerosa in Marburg/Lahn (FRG) zwischen 1962 und 1975. Z Gastroenterol. 1983 Feb;21(2):69–78. [PubMed]
  • Miller DS, Keighley AC, Langman MJ. Changing patterns in epidemiology of Crohn's disease. Lancet. 1974 Sep 21;2(7882):691–693. [PubMed]
  • Calkins BM, Mendeloff AI. Epidemiology of inflammatory bowel disease. Epidemiol Rev. 1986;8:60–91. [PubMed]
  • Humphreys WG. An epidermilogical survey of Crohn's disease in Northern Ireland. Proc R Soc Med. 1975 Sep;68(9):572–574. [PMC free article] [PubMed]
  • Smith IS, Young S, Gillespie G, O'Connor J, Bell JR. Epidemiological aspects of Crohn's disease in Clydesdale 1961-1970. Gut. 1975 Jan;16(1):62–67. [PMC free article] [PubMed]
  • Lanfranchi GA, Michelini M, Brignola C, Campieri M, Cortini C, Marzio L. Uno studio epidemiologico sulle malattie inflammatorie intestinali nella provincia di Bologna. G Clin Med. 1976 Jul-Aug;57(7-8):235–245. [PubMed]
  • Calkins BM, Lilienfeld AM, Garland CF, Mendeloff AI. Trends in incidence rates of ulcerative colitis and Crohn's disease. Dig Dis Sci. 1984 Oct;29(10):913–920. [PubMed]
  • Garland CF, Lilienfeld AM, Mendeloff AI, Markowitz JA, Terrell KB, Garland FC. Incidence rates of ulcerative colitis and Crohn's disease in fifteen areas of the United States. Gastroenterology. 1981 Dec;81(6):1115–1124. [PubMed]
  • Nunes GC, Ahlquist RE., Jr Increasing incidence of Crohn's disease. Am J Surg. 1983 May;145(5):578–581. [PubMed]
  • Myren J, Gjone E, Hertzberg JN, Rygvold O, Semb LS, Fretheim B. Epidemiology of ulcerative colitis and regional enterocolitis (Crohn's disease) in Norway. Scand J Gastroenterol. 1971;6(6):511–514. [PubMed]
  • Tresadern JC, Gear MW, Nicol A. An epidemiological study of regional enteritis in the Gloucester area. Br J Surg. 1973 May;60(5):366–368. [PubMed]
  • Vessey M, Jewell D, Smith A, Yeates D, McPherson K. Chronic inflammatory bowel disease, cigarette smoking, and use of oral contraceptives: findings in a large cohort study of women of childbearing age. Br Med J (Clin Res Ed) 1986 Apr 26;292(6528):1101–1103. [PMC free article] [PubMed]
  • Somerville KW, Logan RF, Edmond M, Langman MJ. Smoking and Crohn's disease. Br Med J (Clin Res Ed) 1984 Oct 13;289(6450):954–956. [PMC free article] [PubMed]
  • Rhodes JM, Cockel R, Allan RN, Hawker PC, Dawson J, Elias E. Colonic Crohn's disease and use of oral contraception. Br Med J (Clin Res Ed) 1984 Feb 25;288(6417):595–596. [PMC free article] [PubMed]
  • Mayberry JF, Rhodes J, Newcombe RG. Increased sugar consumption in Crohn's disease. Digestion. 1980;20(5):323–326. [PubMed]
  • Höj L, Jensen PB, Bonnevie O, Riis P. An epidemiological study of regional enteritis and acute ileitis in Copenhagen County. Scand J Gastroenterol. 1973;8(4):381–384. [PubMed]
  • Rozen P, Zonis J, Yekutiel P, Gilat T. Crohn's disease in the Jewish population of Tel-Aviv-Yafo. Epidemiologic and clinical aspects. Gastroenterology. 1979 Jan;76(1):25–30. [PubMed]
  • Mayberry JF, Rhodes J, Newcombe RG. Crohn's disease in Wales, 1967-1976; an epidemiological survey based on hospital admissions. Postgrad Med J. 1980 May;56(655):336–341. [PMC free article] [PubMed]
  • Sedlack RE, Whisnant J, Elveback LR, Kurland LT. Incidence of Crohn's disease in Olmsted County, Minnesota, 1935-1975. Am J Epidemiol. 1980 Dec;112(6):759–763. [PubMed]
  • De Dombal FT, Burton I, Goligher JC. The early and late results of surgical treatment for Crohn's disease. Br J Surg. 1971 Nov;58(11):805–816. [PubMed]
  • Storgaard L, Bischoff N, Henriksen FW, Fischerman K, Jarnum S. Survival rate in Crohn's disease and ulcerative colitis. Scand J Gastroenterol. 1979;14(2):225–230. [PubMed]
  • Farmer RG, Whelan G, Fazio VW. Long-term follow-up of patients with Crohn's disease. Relationship between the clinical pattern and prognosis. Gastroenterology. 1985 Jun;88(6):1818–1825. [PubMed]
  • Agrez MV, Valente RM, Pierce W, Melton LJ, 3rd, van Heerden JA, Beart RW., Jr Surgical history of Crohn's disease in a well-defined population. Mayo Clin Proc. 1982 Dec;57(12):747–752. [PubMed]
  • Gyde SN, Prior P, Macartney JC, Thompson H, Waterhouse JA, Allan RN. Malignancy in Crohn's disease. Gut. 1980 Dec;21(12):1024–1029. [PMC free article] [PubMed]
  • Weedon DD, Shorter RG, Ilstrup DM, Huizenga KA, Taylor WF. Crohn's disease and cancer. N Engl J Med. 1973 Nov 22;289(21):1099–1103. [PubMed]
  • Greenstein AJ, Sachar DB, Smith H, Janowitz HD, Aufses AH., Jr A comparison of cancer risk in Crohn's disease and ulcerative colitis. Cancer. 1981 Dec 15;48(12):2742–2745. [PubMed]
  • Greenstein AJ, Sachar DB, Smith H, Janowitz HD, Aufses AH., Jr Patterns of neoplasia in Crohn's disease and ulcerative colitis. Cancer. 1980 Jul 15;46(2):403–407. [PubMed]
  • Binder V, Hendriksen C, Kreiner S. Prognosis in Crohn's disease--based on results from a regional patient group from the county of Copenhagen. Gut. 1985 Feb;26(2):146–150. [PMC free article] [PubMed]
  • Mayberry JF, Newcombe RG, Rhodes J. Mortality in Crohn's disease. Q J Med. 1980 Winter;49(193):63–68. [PubMed]

Articles from Gut are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...