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Journal List > Gut > v.4(1); Mar 1963

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Gut. 1963 March; 4(1): 16–19.
PMCID: PMC1413409
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A comparison of the use of Aldactone and Aldactone A in the treatment of hepatic ascites
Stanley Shaldon, Jill A. Ryder, and Myron Garsenstein
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Abstract
In eight patients with cirrhosis and stable ascites controlled on chlorothiazide and spironolactone, a small particle preparation of spironolactone (Aldactone A) was as effective, at one quarter the dosage, as conventional spironolactone (Aldactone). Plasma spironolactone metabolite levels and urinary excretion of spironolactone metabolite were equivalent with both preparations. The variable dosage requirement of spironolactone in patients with cirrhosis and ascites is discussed in relation to these observations.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • CLOWDUS BF, HIGGINS JA, ROSEVEAR JW, SUMMERSKILL WH. Treatment of "refractory" ascites with a new aldosterone antagonist in patients with cirrhosis. Proc Staff Meet Mayo Clin. 1960 Mar 2;35:97–103. [PubMed]
  • GANTT CL, GOCHMAN N, DYNIEWICZ JM. Effect of a detergent on gastrointestinal absorption of a steroid. Lancet. 1961 Mar 4;1(7175):486–487. [PubMed]
  • GOCHMAN N, GANTT CL. A fluorimetric method for the determination of a major spironolactone (Aldactone) metabolite in human plasma. J Pharmacol Exp Ther. 1962 Mar;135:312–316. [PubMed]
  • MORRISON RS, CHALMERS TC. Combined diuretic and steroid therapy in cirrhosis with ascites. Ann N Y Acad Sci. 1960 Oct 11;88:907–914. [PubMed]
  • SHALDON S. The clinical application of aldosterone antagonists in the treatment of oedema. Proc R Soc Med. 1961 Apr;54:259–261. [PubMed]
  • SHALDON S, McLAREN JR, SHERLOCK S. Resistant ascites treated by combined diuretic therapy (spironolactone, mannitol, and chlorothiazide). Lancet. 1960 Mar 19;1(7125):609–613. [PubMed]
  • SHALDON S, SHERLOCK S. [Treatment of ascites in patients with liver cirrhosis.]. Med Klin. 1962 Aug 3;57:1317–1320. [PubMed]
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