|
|
Gut. 1978 June; 19(6): 538–542. | PMCID: PMC1412043 |
Relationship between serum ferritin and total body iron stores in idiopathic haemochromatosis. L W Powell, J W Halliday, and J L Cowlishaw Abstract The relationship between the serum ferritin concentration and total body iron stores was investigated in 41 patients with idiopathic haemochromatosis and 199 first or second degree relatives. Thirty-two relatives (16.1%) had increased iron stores and serum ferritin levels were increased in all but one of them. The false-positive rate in the relatives with normal iron stores was 1.8% compared with 10% for the serum iron concentration and 33% for the transferrin saturation. There was a significant correlation between the serum ferritin concentration and both the chelatable body iron and the hepatic iron concentration. We conclude that in the natural history of classical idiopathic haemochromatosis the serum ferritin concentration is usually raised when hepatic iron stores are increased and before there is architectural damage to the liver. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (719K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Barry M, Cartei G, Sherlock S. Differential ferrioxamine test in haemochromatosis and liver diseases. Gut. 1969 Sep;10(9):697–704. [PubMed]
- Bomford A, Eddleston AL, Kennedy LA, Batchelor JR, Williams R. Histocompatibility antigens as markers of abnormal iron metabolism in patients with idiopathic haemochromatosis and their relatives. Lancet. 1977 Feb 12;1(8007):327–329. [PubMed]
- Cox TM, Peters TJ. Uptake of iron by duodenal biopsy specimens from patients with iron-deficiency anaemia and primary haemochromatosis. Lancet. 1978 Jan 21;1(8056):123–124. [PubMed]
- Crosby WH, Likhite VV, O'Brien JE, Forman D. Serum iron levels in ostensibly normal people. JAMA. 1974 Jan 21;227(3):310–312. [PubMed]
- Edwards CQ, Carroll M, Bray P, Cartwright GE. Hereditary hemochromatosis. Diagnosis in siblings and children. N Engl J Med. 1977 Jul 7;297(1):7–13. [PubMed]
- Feller ER, Pont A, Wands JR, Carter EA, Foster G, Kourides IA, Isselbacher KJ. Familial hemochromatosis. Physiologic studies in the precirrhotic stage of the disease. N Engl J Med. 1977 Jun 23;296(25):1422–1426. [PubMed]
- FINCH SC, FINCH CA. Idiopathic hemochromatosis, an iron storage disease. A. Iron metabolism in hemochromatosis. Medicine (Baltimore). 1955 Dec;34(4):381–430. [PubMed]
- Grace ND, Powell LW. Iron storage disorders of the liver. Gastroenterology. 1974 Dec;67(6):1257–1283. [PubMed]
- Halliday JW, Gera KL, Powell LW. Solid phase radioimmunossay for serum ferritin. Clin Chim Acta. 1975 Feb 8;58(3):207–214. [PubMed]
- Halliday JW, Russo AM, Cowlishaw JL, Powell LW. Serum-ferritin in diagnosis of haemochromatosis. A study of 43 families. Lancet. 1977 Sep 24;2(8039):621–624. [PubMed]
- Jacobs A, Miller F, Worwood M, Beamish MR, Wardrop CA. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J. 1972 Oct 28;4(5834):206–208. [PubMed]
- Lipschitz DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med. 1974 May 30;290(22):1213–1216. [PubMed]
- PETERS T, GIOVANNIELLO TJ, APT L, ROSS JF. A new method for the determination of serum iron-binding capacity. I. J Lab Clin Med. 1956 Aug;48(2):274–279. [PubMed]
- Powell LW. Changing concepts in haemochromatosis. Postgrad Med J. 1970 Apr;46(534):200–209. [PubMed]
- Powell LW. Iron storage in relatives of patients with haemochromatosis and in relatives of patients with alcoholic cirrhosis and haemosiderosis. A comparative study of 27 families. Q J Med. 1965 Oct;34(136):427–442. [PubMed]
- Powell LW. Normal human iron storage and its relation to ethanol consumption. Australas Ann Med. 1966 May;15(2):110–115. [PubMed]
- Powell LW, Campbell CB, Wilson E. Intestinal mucosal uptake of iron and iron retention in idiopathic haemochromatosis as evidence for a mucosal abnormality. Gut. 1970 Sep;11(9):727–731. [PubMed]
- Prieto J, Barry M, Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology. 1975 Mar;68(3):525–533. [PubMed]
- SCHEUER PJ, WILLIAMS R, MUIR AR. Hepatic pathology in relatives of patients with haemochromatosis. J Pathol Bacteriol. 1962 Jul;84:53–64. [PubMed]
- Simon M, Bourel M, Fauchet R, Genetet B. Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. Gut. 1976 May;17(5):332–334. [PubMed]
- Simon M, Bourel M, Genetet B, Fauchet R, Edan G, Brissot P. Idiopathic hemochromatosis and iron overload in alcoholic liver disease: differentiation by HLA phenotype. Gastroenterology. 1977 Oct;73(4 Pt 1):655–658. [PubMed]
- Walters GO, Miller FM, Worwood M. Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol. 1973 Oct;26(10):770–772. [PubMed]
- Wands JR, Rowe JA, Mezey SE, Waterbury LA, Wright JR, Halliday JW, Isselbacher KJ, Powell LW. Normal serum ferritin concentrations in precirrhotic hemochromatosis. N Engl J Med. 1976 Feb 5;294(6):302–305. [PubMed]
- WILLIAMS R, SCHEUER PJ, SHERLOCK S. The inheritance of idiopathic haemochromatosis. A clinical and liver biopsy study of 16 families. Q J Med. 1962 Jul;31:249–265. [PubMed]
- Williams R, Smith PM, Spicer EJ, Barry M, Sherlock S. Venesection therapy in idiopathic haemochromatosis. An analysis of 40 treated and 18 untreated patients. Q J Med. 1969 Jan;38(149):1–16. [PubMed]
|
This article has been