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Gut. 1976 Sep; 17(9): 735–739.
PMCID: PMC1411281

Transient paraproteinaemia in a patient with coeliac disease.


A case is reported of a 43 year old man who suffered from a grass pollen allergy and a malabsorption syndrome and in whom a paraproteinaemia was found. The grass pollen hypersensitivity was abolished by desensitization. The malabsorption syndrome was found to be due to coeliac disease--that is, a "flat" mucosa of the jejunum with an almost normal ileal mucosa--followed by clinical recovery and morphological improvement on a gluten-free diet. A short period of gluten reintroduction caused deterioration of the jejunum. The monoclonal immunoglobulin (IgG-gamma) diminished and disappeared in the course of three years. Although it has not been possible to demonstrate that this paraprotein had anti-gliadin activity, it is suggested that the constant stimulation of the gut reticuloendothelial system by gluten might bear some relation to the appearance of the paraproteinaemia.

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Selected References

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  • Blecher TE, Brzechwa-Ajdukiewicz A, McCarthy CF, Read AE. Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut. 1969 Jan;10(1):57–62. [PMC free article] [PubMed]
  • Cooke KB. Essential paraproteinaemia. Proc R Soc Med. 1969 Aug;62(8):777–778. [PMC free article] [PubMed]
  • Dahlqvist A. Assay of intestinal disaccharidases. Enzymol Biol Clin (Basel) 1970;11(1):52–66. [PubMed]
  • DAMESHEK W, SCHWARTZ RS. Leukemia and auto-immunization- some possible relationships. Blood. 1959 Oct;14:1151–1158. [PubMed]
  • Doe WF, Evans D, Hobbs JR, Booth CC. Coeliac disease, vasculitis, and cryoglobulinaemia. Gut. 1972 Feb;13(2):112–123. [PMC free article] [PubMed]
  • Dunnill MS, Whitehead R. A method for the quantitation of small intestinal biopsy specimens. J Clin Pathol. 1972 Mar;25(3):243–246. [PMC free article] [PubMed]
  • GOUGH KR, READ AE, NAISH JM. Intestinal reticulosis as a complication of idiopathic steatorrhoea. Gut. 1962 Sep;3:232–239. [PMC free article] [PubMed]
  • Harris OD, Cooke WT, Thompson H, Waterhouse JA. Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med. 1967 Jun;42(6):899–912. [PubMed]
  • Hobbs JR, Hepner GW, Douglas AP, Crabbé PA, Johansson SG. Immunological mystery of coeliac disease. Lancet. 1969 Sep 20;2(7621):649–650. [PubMed]
  • McCarthy CF, Fraser ID, Evans KT, Read AE. Lymphoreticular dysfunction in idiopathic steatorrhoea. Gut. 1966 Apr;7(2):140–148. [PMC free article] [PubMed]
  • Metzger H. Myeloma proteins and antibodies. Am J Med. 1969 Dec;47(6):837–844. [PubMed]
  • O'Donoghue DP, Lancaster-Smith M, Kumar PJ. Proceedings: Depletion of thymus-dependent lymphocytes in adult coeliac disease. Gut. 1975 May;16(5):392–393. [PubMed]
  • Penny R, Hughes S. Repeated stimulation of the reticuloendothelial system and the development of plasma-cell dyscrasias. Lancet. 1970 Jan 10;1(7637):77–78. [PubMed]
  • Seligmann M, Danon F, Clauvel JP. Natural history of monoclonal immunoglobulins. Br Med J. 1971 May 8;2(5757):321–322. [PMC free article] [PubMed]
  • Weetman AP, Haggith J, Douglas AP. Proceedings: Enteric loss of lymphocytes in coeliac disease and in Crohn's disease. Gut. 1974 Oct;15(10):823–823. [PubMed]
  • WEIBEL ER. Principles and methods for the morphometric study of the lung and other organs. Lab Invest. 1963 Feb;12:131–155. [PubMed]
  • Young VH. Transient paraproteins. Proc R Soc Med. 1969 Aug;62(8):778–780. [PMC free article] [PubMed]

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