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Am J Public Health. 1991 April; 81(4): 458–461.
PMCID: PMC1405033

Caffeine consumption during pregnancy and fetal growth.

Abstract

BACKGROUND: The purpose of this study was to examine the association between maternal caffeine consumption and low birthweight, intrauterine growth retardation, and prematurity, adjusting for multiple confounders. METHODS: Data obtained from birth certificates and interviews on 1,230 women with singleton live births were analyzed to evaluate the potential influence of caffeine consumption during the first trimester on fetal growth. RESULTS: The crude odds ratio for intrauterine growth retardation in infants of women reporting heavy caffeine consumption (greater than 300 mg/day) was 3.86 (95% CI = 1.80, 8.40) which decreased to 2.90 (95% CI = 1.23, 6.87) after controlling for confounding factors. The adjusted odds ratio for low birthweight and heavy maternal caffeine consumption was also elevated (OR = 2.05; 95% CI = 0.86, 4.88). Women who reduced their caffeine intake from greater than 300 mg/day to less than that early in pregnancy had lower risks of delivering infants with either intrauterine growth retardation or low birthweight than women who continued to consume that amount. Preterm delivery appeared to be unrelated to caffeine consumption. CONCLUSIONS: Taken together with studies reporting similar findings, these results suggest that heavy caffeine consumption increases the risk for fetal growth retardation.

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Selected References

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  • Martin TR, Bracken MB. The association between low birth weight and caffeine consumption during pregnancy. Am J Epidemiol. 1987 Nov;126(5):813–821. [PubMed]
  • Caan BJ, Goldhaber MK. Caffeinated beverages and low birthweight: a case-control study. Am J Public Health. 1989 Sep;79(9):1299–1300. [PMC free article] [PubMed]
  • Watkinson B, Fried PA. Maternal caffeine use before, during and after pregnancy and effects upon offspring. Neurobehav Toxicol Teratol. 1985 Jan-Feb;7(1):9–17. [PubMed]
  • Brooke OG, Anderson HR, Bland JM, Peacock JL, Stewart CM. Effects on birth weight of smoking, alcohol, caffeine, socioeconomic factors, and psychosocial stress. BMJ. 1989 Mar 25;298(6676):795–801. [PMC free article] [PubMed]
  • Linn S, Schoenbaum SC, Monson RR, Rosner B, Stubblefield PG, Ryan KJ. No association between coffee consumption and adverse outcomes of pregnancy. N Engl J Med. 1982 Jan 21;306(3):141–145. [PubMed]
  • Windham GC, Fenster L, Swan SH, Neutra RR. Use of video display terminals during pregnancy and the risk of spontaneous abortion, low birthweight, or intrauterine growth retardation. Am J Ind Med. 1990;18(6):675–688. [PubMed]
  • Williams RL, Creasy RK, Cunningham GC, Hawes WE, Norris FD, Tashiro M. Fetal growth and perinatal viability in California. Obstet Gynecol. 1982 May;59(5):624–632. [PubMed]
  • Bunker ML, McWilliams M. Caffeine content of common beverages. J Am Diet Assoc. 1979 Jan;74(1):28–32. [PubMed]
  • Kelly JP, Rosenberg L, Kaufman DW, Shapiro S. Reliability of personal interview data in a hospital-based case-control study. Am J Epidemiol. 1990 Jan;131(1):79–90. [PubMed]
  • Berkowitz GS, Holford TR, Berkowitz RL. Effects of cigarette smoking, alcohol, coffee and tea consumption on preterm delivery. Early Hum Dev. 1982 Dec 6;7(3):239–250. [PubMed]
  • Coffee consumption during pregnancy. N Engl J Med. 1982 Jun 24;306(25):1548–1550. [PubMed]
  • GOLDSTEIN A, WARREN R. Passage of caffeine into human gonadal and fetal tissue. Biochem Pharmacol. 1962 Feb;11:166–168. [PubMed]
  • Morris MB, Weinstein L. Caffeine and the fetus: is trouble brewing? Am J Obstet Gynecol. 1981 Jul 15;140(6):607–610. [PubMed]
  • Kirkinen P, Jouppila P, Koivula A, Vuori J, Puukka M. The effect of caffeine on placental and fetal blood flow in human pregnancy. Am J Obstet Gynecol. 1983 Dec 15;147(8):939–942. [PubMed]
  • Weathersbee PS, Lodge JR. Caffeine: its direct and indirect influence on reproduction. J Reprod Med. 1977 Aug;19(2):55–63. [PubMed]

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