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Immunology. 1988 December; 65(4): 623–628. | PMCID: PMC1385574 |
K-cell-mediated cytotoxicity induced with rat monoclonal antibodies. I. Antibodies of various isotypes differ in their ability to induce cytotoxicity mediated by rat and human effectors. D M Chassoux, L G Linares-Cruz, H Bazin, and M Stanislawski CNRS ER 278, Institut de Recerches Scientifiques sur le Cancer, Villejuif, France. Abstract Among the rat antibodies tested in this study, monoclonals of IgG2a isotype were the best, IgG1 and IgG2b being also effective, for induction of K-cell-mediated cytotoxicity of relevant nucleated target cells by rat effectors (Nude spleen cells). The single rat monoclonal IgE tested was also active. Rat antibodies of IgM and IgA classes of immunoglobulins were not active in that system. IgG2c and IgD monoclonals were not tested. Using the same panel of reagents, cytotoxicity mediated by human K cells (peripheral blood mononuclear cells) was only induced by the IgG2b class of rat monoclonals. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (993K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Bazin H, Beckers A, Querinjean P. Three classes and four (sub)classes of rat immunoglobulins: IgM, IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c. Eur J Immunol. 1974 Jan;4(1):44–48. [PubMed]
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