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Gut. Aug 1996; 39(2): 299–305.
PMCID: PMC1383315

Variability of gastrointestinal transit in healthy women and men.

Abstract

BACKGROUND AND AIMS: Measurements of gastrointestinal transit are made in clinical and research gastroenterology, yet their intrinsic variability is not well characterised. In particular, an influence of hormones on transit has been proposed as the basis for gastrointestinal symptoms that vary with the menstrual cycle. Our aims were to quantify individual differences in transit during the menstrual cycle in healthy women and to compare these with the intrinsic variability in healthy men. METHODS: On two occasions, whole gut transit was assessed scintigraphically and colonic transit quantified by radio-opaque markers. Thirty two healthy volunteers (12 women, 20 men) were studied, women during the follicular and luteal phases, men twice within a similar four week period. Diets and exercise were standardised prior to and during both studies. RESULTS: Colonic transit was significantly faster in men, and postlag gastric emptying was also more rapid; other indices of regional transit were not different between the sexes. Total colonic transit time was equally well reflected by the scintigraphic and radio-opaque marker methods. Important intraindividual differences were noted in both sexes. The variances in our samples predicted an 80% chance of detecting (with 95% confidence) a mean effect of menstrual hormones on transit that was in the same range as the intrinsic variation in men. CONCLUSIONS: Colonic transit was faster in men than in women. Although group means in the two studies were almost identical, single assessments of transit in subjects sometimes exhibited considerable variability, implying broad biological variations. Given this intrinsic variability, the influence of menstrual hormones on gastrointestinal transit must be small and of doubtful clinical significance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Cann PA, Read NW, Brown C, Hobson N, Holdsworth CD. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. Gut. 1983 May;24(5):405–411. [PMC free article] [PubMed]
  • Stivland T, Camilleri M, Vassallo M, Proano M, Rath D, Brown M, Thomforde G, Pemberton J, Phillips S. Scintigraphic measurement of regional gut transit in idiopathic constipation. Gastroenterology. 1991 Jul;101(1):107–115. [PubMed]
  • Vassallo M, Camilleri M, Phillips SF, Brown ML, Chapman NJ, Thomforde GM. Transit through the proximal colon influences stool weight in the irritable bowel syndrome. Gastroenterology. 1992 Jan;102(1):102–108. [PubMed]
  • La Brooy SJ, Male PJ, Beavis AK, Misiewicz JJ. Assessment of the reproducibility of the lactulose H2 breath test as a measure of mouth to caecum transit time. Gut. 1983 Oct;24(10):893–896. [PMC free article] [PubMed]
  • Proano M, Camilleri M, Phillips SF, Brown ML, Thomforde GM. Transit of solids through the human colon: regional quantification in the unprepared bowel. Am J Physiol. 1990 Jun;258(6 Pt 1):G856–G862. [PubMed]
  • Arhan P, Devroede G, Jehannin B, Lanza M, Faverdin C, Dornic C, Persoz B, Tétreault L, Perey B, Pellerin D. Segmental colonic transit time. Dis Colon Rectum. 1981 Nov-Dec;24(8):625–629. [PubMed]
  • Metcalf AM, Phillips SF, Zinsmeister AR, MacCarty RL, Beart RW, Wolff BG. Simplified assessment of segmental colonic transit. Gastroenterology. 1987 Jan;92(1):40–47. [PubMed]
  • Scarpello JH, Barber DC, Hague RV, Cullen DR, Sladen GE. Gastric emptying of solid meals in diabetics. Br Med J. 1976 Sep 18;2(6037):671–673. [PMC free article] [PubMed]
  • Collins PJ, Horowitz M, Cook DJ, Harding PE, Shearman DJ. Gastric emptying in normal subjects--a reproducible technique using a single scintillation camera and computer system. Gut. 1983 Dec;24(12):1117–1125. [PMC free article] [PubMed]
  • Brophy CM, Moore JG, Christian PE, Egger MJ, Taylor AT. Variability of gastric emptying measurements in man employing standardized radiolabeled meals. Dig Dis Sci. 1986 Aug;31(8):799–806. [PubMed]
  • Camilleri M, Zinsmeister AR. Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders. Gastroenterology. 1992 Jul;103(1):36–42. [PubMed]
  • Camilleri M, Zinsmeister AR, Greydanus MP, Brown ML, Proano M. Towards a less costly but accurate test of gastric emptying and small bowel transit. Dig Dis Sci. 1991 May;36(5):609–615. [PubMed]
  • Charles F, Camilleri M, Phillips SF, Thomforde GM, Forstrom LA. Scintigraphy of the whole gut: clinical evaluation of transit disorders. Mayo Clin Proc. 1995 Feb;70(2):113–118. [PubMed]
  • Gill RC, Bowes KL, Kingma YJ. Effect of progesterone on canine colonic smooth muscle. Gastroenterology. 1985 Jun;88(6):1941–1947. [PubMed]
  • Datta S, Hey VM, Pleuvry BJ. Effects of pregnancy and associated hormones in mouse intestine, in vivo and in vitro. Pflugers Arch. 1974 Feb 4;346(2):87–95. [PubMed]
  • Davies GJ, Crowder M, Reid B, Dickerson JW. Bowel function measurements of individuals with different eating patterns. Gut. 1986 Feb;27(2):164–169. [PMC free article] [PubMed]
  • Wald A, Van Thiel DH, Hoechstetter L, Gavaler JS, Egler KM, Verm R, Scott L, Lester R. Gastrointestinal transit: the effect of the menstrual cycle. Gastroenterology. 1981 Jun;80(6):1497–1500. [PubMed]
  • Datz FL, Christian PE, Moore J. Gender-related differences in gastric emptying. J Nucl Med. 1987 Jul;28(7):1204–1207. [PubMed]
  • Lawaetz O, Dige-Petersen H. Gastric emptying of liquid meals. A study in 88 normal persons. Ann Chir Gynaecol. 1989;78(4):267–276. [PubMed]
  • Hutson WR, Roehrkasse RL, Wald A. Influence of gender and menopause on gastric emptying and motility. Gastroenterology. 1989 Jan;96(1):11–17. [PubMed]
  • Notivol R, Carrio I, Cano L, Estorch M, Vilardell F. Gastric emptying of solid and liquid meals in healthy young subjects. Scand J Gastroenterol. 1984 Nov;19(8):1107–1113. [PubMed]
  • Bisdee JT, Garlick PJ, James WP. Metabolic changes during the menstrual cycle. Br J Nutr. 1989 May;61(3):641–650. [PubMed]
  • Kamm MA, Farthing MJ, Lennard-Jones JE. Bowel function and transit rate during the menstrual cycle. Gut. 1989 May;30(5):605–608. [PMC free article] [PubMed]
  • Wyman JB, Heaton KW, Manning AP, Wicks AC. Variability of colonic function in healthy subjects. Gut. 1978 Feb;19(2):146–150. [PMC free article] [PubMed]
  • Turnbull GK, Thompson DG, Day S, Martin J, Walker E, Lennard-Jones JE. Relationships between symptoms, menstrual cycle and orocaecal transit in normal and constipated women. Gut. 1989 Jan;30(1):30–34. [PMC free article] [PubMed]
  • Horowitz M, Maddern GJ, Chatterton BE, Collins PJ, Petrucco OM, Seamark R, Shearman DJ. The normal menstrual cycle has no effect on gastric emptying. Br J Obstet Gynaecol. 1985 Jul;92(7):743–746. [PubMed]
  • Monés J, Carrió I, Calabuig R, Estorch M, Sainz S, Berná L, Vilardell F. Influence of the menstrual cycle and of menopause on the gastric emptying rate of solids in female volunteers. Eur J Nucl Med. 1993 Jul;20(7):600–602. [PubMed]
  • Simmons L, Heitkemper M, Shaver J. Gastrointestinal function during the menstrual cycle. Health Care Women Int. 1988;9(3):201–209. [PubMed]
  • Whitehead WE, Cheskin LJ, Heller BR, Robinson JC, Crowell MD, Benjamin C, Schuster MM. Evidence for exacerbation of irritable bowel syndrome during menses. Gastroenterology. 1990 Jun;98(6):1485–1489. [PubMed]
  • Heitkemper MM, Jarrett M. Pattern of gastrointestinal and somatic symptoms across the menstrual cycle. Gastroenterology. 1992 Feb;102(2):505–513. [PubMed]
  • Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. Br Med J. 1978 Sep 2;2(6138):653–654. [PMC free article] [PubMed]
  • Basilisco G, Camboni G, Bozzani A, Vita P, Doldi S, Bianchi PA. Orocecal transit delay in obese patients. Dig Dis Sci. 1989 Apr;34(4):509–512. [PubMed]
  • Horowitz M, Collins PJ, Cook DJ, Harding PE, Shearman DJ. Abnormalities of gastric emptying in obese patients. Int J Obes. 1983;7(5):415–421. [PubMed]
  • Wright RA, Krinsky S, Fleeman C, Trujillo J, Teague E. Gastric emptying and obesity. Gastroenterology. 1983 Apr;84(4):747–751. [PubMed]
  • Anderson JW, Bridges SR. Dietary fiber content of selected foods. Am J Clin Nutr. 1988 Mar;47(3):440–447. [PubMed]
  • Lee IM, Paffenbarger RS, Jr, Hsieh CC. Time trends in physical activity among college alumni, 1962-1988. Am J Epidemiol. 1992 Apr 15;135(8):915–925. [PubMed]
  • Derogatis LR, Rickels K, Rock AF. The SCL-90 and the MMPI: a step in the validation of a new self-report scale. Br J Psychiatry. 1976 Mar;128:280–289. [PubMed]
  • Camilleri M, Colemont LJ, Phillips SF, Brown ML, Thomforde GM, Chapman N, Zinsmeister AR. Human gastric emptying and colonic filling of solids characterized by a new method. Am J Physiol. 1989 Aug;257(2 Pt 1):G284–G290. [PubMed]
  • Connell AM, Hilton C, Irvine G, Lennard-Jones JE, Misiewicz JJ. Variation of bowel habit in two population samples. Br Med J. 1965 Nov 6;2(5470):1095–1099. [PMC free article] [PubMed]
  • Heaton KW, Radvan J, Cripps H, Mountford RA, Braddon FE, Hughes AO. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut. 1992 Jun;33(6):818–824. [PMC free article] [PubMed]
  • Bruce LA, Behsudi FM, Danhof IE. Smooth muscle mechanical responses in vitro to bethanechol after progesterone in male rat. Am J Physiol. 1978 Oct;235(4):E422–E428. [PubMed]
  • Bruce LA, Behsudi FM. Progesterone effects on three regional gastrointestinal tissues. Life Sci. 1979 Aug 27;25(9):729–734. [PubMed]
  • Bruce LA, Behsudi FM. Differential inhibition of regional gastrointestinal tissue to progesterone in the rat. Life Sci. 1980 Aug 4;27(5):427–434. [PubMed]
  • Bruce LA, Beshudi FM. Increased gastrointestinal motility in vitro following chronic estrogen treatment in male rats. Proc Soc Exp Biol Med. 1981 Mar;166(3):355–359. [PubMed]
  • Cummings JH, Wiggins HS. Transit through the gut measured by analysis of a single stool. Gut. 1976 Mar;17(3):219–223. [PMC free article] [PubMed]
  • Hinton JM, Lennard-Jones JE, Young AC. A ne method for studying gut transit times using radioopaque markers. Gut. 1969 Oct;10(10):842–847. [PMC free article] [PubMed]
  • Levitt MD. Production and excretion of hydrogen gas in man. N Engl J Med. 1969 Jul 17;281(3):122–127. [PubMed]
  • Rao SS, Read NW, Brown C, Bruce C, Holdsworth CD. Studies on the mechanism of bowel disturbance in ulcerative colitis. Gastroenterology. 1987 Nov;93(5):934–940. [PubMed]
  • Evans RC, Kamm MA, Hinton JM, Lennard-Jones JE. The normal range and a simple diagram for recording whole gut transit time. Int J Colorectal Dis. 1992 Feb;7(1):15–17. [PubMed]
  • Lawson M, Everson GT, Klingensmith W, Kern F., Jr Coordination of gastric and gallbladder emptying after ingestion of a regular meal. Gastroenterology. 1983 Oct;85(4):866–870. [PubMed]
  • Stephen AM, Wiggins HS, Englyst HN, Cole TJ, Wayman BJ, Cummings JH. The effect of age, sex and level of intake of dietary fibre from wheat on large-bowel function in thirty healthy subjects. Br J Nutr. 1986 Sep;56(2):349–361. [PubMed]
  • Hinds JP, Stoney B, Wald A. Does gender or the menstrual cycle affect colonic transit? Am J Gastroenterol. 1989 Feb;84(2):123–126. [PubMed]
  • Meier R, Beglinger C, Dederding JP, Meyer-Wyss B, Fumagalli M, Rowedder A, Turberg Y, Brignoli R. Influence of age, gender, hormonal status and smoking habits on colonic transit time. Neurogastroenterol Motil. 1995 Dec;7(4):235–238. [PubMed]

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