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Gut. 1995 November; 37(5): 727–730. | PMCID: PMC1382882 |
Hepatocellular carcinoma and African iron overload. I T Gangaidzo and V R Gordeuk Department of Medicine, UZ School of Medicine, University of Zimbabwe, Harare, Zimbabwe. Abstract Both hepatocellular carcinoma (HCC) and iron overload are important health problems in Africa. Chronic hepatitis B virus (HBV) infection is recognised as a major risk factor for HCC, but iron overload in Africans has not been considered in pathogenesis. Up to half the patients with HCC in Africa do not have any recognised risk factors such as preceding chronic HBV infection, and other risk factors remain unidentified. HCC is an important complication of HLA-linked haemochromatosis, an iron loading disorder found in Europeans. It is proposed that African iron overload might also be a risk factor for HCC. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (845K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Kew MC, Desmyter J, Bradburne AF, Macnab GM. Hepatitis B virus infection in southern African blacks with hepatocellular cancer. J Natl Cancer Inst. 1979 Mar;62(3):517–520. [PubMed]
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