• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of gutGutView this articleSubmit a manuscriptReceive email alertsContact usBMJ
Gut. Aug 1995; 37(2): 174–176.
PMCID: PMC1382712

Combined radiochemotherapy for postoperative recurrence of oesophageal cancer.


Postoperative recurrences are common after resection for oesophageal cancer. From January 1986 to September 1993 31 patients (30 males, one female, mean (SD) age: 57.5 (8.8) years) were treated for locoregional recurrence (n = 24), metastases (n = 6) or both (n = 1) occurring 15.0 (12.6) months after initial surgery. Radiotherapy and chemotherapy were combined in all cases. Symptomatic improvement was seen in 23 cases (74%) and lasted (excluding treatment period) for 6.3 (4) months. Objective tumoral response was seen in 20 patients (65%) including eight (26%) complete responses. Survival rates were at respectively six months, one, two, and three years: 70.7%, 47.1%, 17.1%, 4.3%. In conclusion, these results show that combined therapy could have a beneficial symptomatic effect and can be associated with prolonged survival in patients with postoperative recurrences of oesophageal cancer.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (625K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Le Prise E, Etienne PL, Meunier B, Maddern G, Ben Hassel M, Gedouin D, Boutin D, Campion JP, Launois B. A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus. Cancer. 1994 Apr 1;73(7):1779–1784. [PubMed]
  • Müller JM, Erasmi H, Stelzner M, Zieren U, Pichlmaier H. Surgical therapy of oesophageal carcinoma. Br J Surg. 1990 Aug;77(8):845–857. [PubMed]
  • Peracchia A, Bardini R, Castoro C, Sorrentino P, Segalin A, Ruol A, Asolati M, De Vido L. La lymphadénectomie dans le traitement du cancer de l'oesophage intrathoracique. A propos de l'étude de 240 cas. Ann Chir. 1990;44(1):9–17. [PubMed]
  • Carlisle JG, Quint LE, Francis IR, Orringer MB, Smick JF, Gross BH. Recurrent esophageal carcinoma: CT evaluation after esophagectomy. Radiology. 1993 Oct;189(1):271–275. [PubMed]
  • Mandard AM, Chasle J, Marnay J, Villedieu B, Bianco C, Roussel A, Elie H, Vernhes JC. Autopsy findings in 111 cases of esophageal cancer. Cancer. 1981 Jul 15;48(2):329–335. [PubMed]
  • Kato H, Tachimori Y, Mizobuchi S, Igaki H, Ochiai A. Cervical, mediastinal, and abdominal lymph node dissection (three-field dissection) for superficial carcinoma of the thoracic esophagus. Cancer. 1993 Nov 15;72(10):2879–2882. [PubMed]
  • Gill PG, Denham JW, Jamieson GG, Devitt PG, Yeoh E, Olweny C. Patterns of treatment failure and prognostic factors associated with the treatment of esophageal carcinoma with chemotherapy and radiotherapy either as sole treatment or followed by surgery . J Clin Oncol. 1992 Jul;10(7):1037–1043. [PubMed]
  • Leichman L, Herskovic A, Leichman CG, Lattin PB, Steiger Z, Tapazoglou E, Rosenberg JC, Arbulu A, Asfaw I, Kinzie J. Nonoperative therapy for squamous-cell cancer of the esophagus. J Clin Oncol. 1987 Mar;5(3):365–370. [PubMed]
  • Chan A, Wong A, Arthur K. Concomitant 5-fluorouracil infusion, mitomycin C and radical radiation therapy in esophageal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 1989 Jan;16(1):59–65. [PubMed]
  • Coia LR, Engstrom PF, Paul AR, Stafford PM, Hanks GE. Long-term results of infusional 5-FU, mitomycin-C and radiation as primary management of esophageal carcinoma. Int J Radiat Oncol Biol Phys. 1991 Jan;20(1):29–36. [PubMed]
  • Forastiere AA, Orringer MB, Perez-Tamayo C, Urba SG, Zahurak M. Preoperative chemoradiation followed by transhiatal esophagectomy for carcinoma of the esophagus: final report. J Clin Oncol. 1993 Jun;11(6):1118–1123. [PubMed]
  • Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, Vaitkevicius V, Cooper J, Byhardt R, Davis L, Emami B. Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med. 1992 Jun 11;326(24):1593–1598. [PubMed]
  • Launois B, Paul JL, Lygidakis NJ, Campion JP, Malledant Y, Grossetti D, Delarue D. Results of the surgical treatment of carcinoma of the esophagus. Surg Gynecol Obstet. 1983 Jun;156(6):753–760. [PubMed]
  • Goldminc M, Maddern G, Le Prise E, Meunier B, Campion JP, Launois B. Oesophagectomy by a transhiatal approach or thoracotomy: a prospective randomized trial. Br J Surg. 1993 Mar;80(3):367–370. [PubMed]

Articles from Gut are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...