• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of gutGutView this articleSubmit a manuscriptReceive email alertsContact usBMJ
Gut. Aug 1991; 32(8): 913–917.
PMCID: PMC1378961

Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

Abstract

Serum tumour necrosis factor alpha (TNF alpha) concentrations were measured by enzyme linked immunoadsorbent assay in 31 normal children and during 65 episodes of clinical remission and 54 episodes of relapse in 92 children with chronic inflammatory bowel disease. An appreciable rise in TNF alpha was found only in children in relapse of ulcerative colitis and colonic Crohn's disease. The group of children with small bowel Crohn's disease in relapse did not show increases of TNF alpha above control concentrations, despite an equivalent rise in disease indices. Height velocity was depressed in children with relapse of large bowel Crohn's disease and ulcerative colitis compared with the equivalent condition in remission. The impairment of growth velocity was significantly greater in relapse of large bowel Crohn's disease and ulcerative colitis than in small bowel Crohn's disease alone, although for the subgroups in stage 1 puberty (prepubertal) the differences were not significant. Inadequate growth in chronic inflammatory bowel disease is currently ascribed to inadequate nutrition and TNF alpha may contribute to this through its cachexia inducing effects. It may, in addition, diminish pituitary growth hormone release. These results suggest that production of TNF alpha may be associated with growth failure in relapse of colonic inflammatory bowel disease.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (970K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Tracey KJ, Lowry SF, Cerami A. Cachectin: a hormone that triggers acute shock and chronic cachexia. J Infect Dis. 1988 Mar;157(3):413–420. [PubMed]
  • Ziegler EJ. Tumor necrosis factor in humans. N Engl J Med. 1988 Jun 9;318(23):1533–1535. [PubMed]
  • Tracey KJ, Vlassara H, Cerami A. Cachectin/tumour necrosis factor. Lancet. 1989 May 20;1(8647):1122–1126. [PubMed]
  • Clark IA, Cowden WB, Butcher GA, Hunt NH. Possible roles of tumor necrosis factor in the pathology of malaria. Am J Pathol. 1987 Oct;129(1):192–199. [PMC free article] [PubMed]
  • Balkwill F, Osborne R, Burke F, Naylor S, Talbot D, Durbin H, Tavernier J, Fiers W. Evidence for tumour necrosis factor/cachectin production in cancer. Lancet. 1987 Nov 28;2(8570):1229–1232. [PubMed]
  • Maury CP, Teppo AM. Tumor necrosis factor in the serum of patients with systemic lupus erythematosus. Arthritis Rheum. 1989 Feb;32(2):146–150. [PubMed]
  • Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, Cerami A, Wolff SM, Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med. 1988 Jun 9;318(23):1481–1486. [PubMed]
  • Waage A, Halstensen A, Espevik T. Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet. 1987 Feb 14;1(8529):355–357. [PubMed]
  • Nadal D, Leppert D, Frei K, Gallo P, Lamche H, Fontana A. Tumour necrosis factor-alpha in infectious meningitis. Arch Dis Child. 1989 Sep;64(9):1274–1279. [PMC free article] [PubMed]
  • Mahida YR, Patel S, Wu K, Jewell DP. Interleukin 2 receptor expression by macrophages in inflammatory bowel disease. Clin Exp Immunol. 1988 Dec;74(3):382–386. [PMC free article] [PubMed]
  • MacDonald TT, Hutchings P, Choy MY, Murch S, Cooke A. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol. 1990 Aug;81(2):301–305. [PMC free article] [PubMed]
  • Selby WS, Poulter LW, Hobbs S, Jewell DP, Janossy G. Heterogeneity of HLA-DR-positive histiocytes in human intestinal lamina propria: a combined histochemical and immunohistological analysis. J Clin Pathol. 1983 Apr;36(4):379–384. [PMC free article] [PubMed]
  • Choy MY, Walker-Smith JA, Williams CB, MacDonald TT. Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut. 1990 Dec;31(12):1365–1370. [PMC free article] [PubMed]
  • Tracey KJ, Wei H, Manogue KR, Fong Y, Hesse DG, Nguyen HT, Kuo GC, Beutler B, Cotran RS, Cerami A, et al. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med. 1988 Mar 1;167(3):1211–1227. [PMC free article] [PubMed]
  • Sun XM, Hsueh W. Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. J Clin Invest. 1988 May;81(5):1328–1331. [PMC free article] [PubMed]
  • Wakefield AJ, Sawyerr AM, Dhillon AP, Pittilo RM, Rowles PM, Lewis AA, Pounder RE. Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet. 1989 Nov 4;2(8671):1057–1062. [PubMed]
  • Satsangi J, Wolstencroft RA, Cason J, Ainley CC, Dumonde DC, Thompson RP. Interleukin 1 in Crohn's disease. Clin Exp Immunol. 1987 Mar;67(3):594–605. [PMC free article] [PubMed]
  • Evans DA, Jacobs DO, Revhaug A, Wilmore DW. The effects of tumor necrosis factor and their selective inhibition by ibuprofen. Ann Surg. 1989 Mar;209(3):312–321. [PMC free article] [PubMed]
  • Kelts DG, Grand RJ, Shen G, Watkins JB, Werlin SL, Boehme C. Nutritional basis of growth failure in children and adolescents with Crohn's disease. Gastroenterology. 1979 Apr;76(4):720–727. [PubMed]
  • Evans M, Walker-Smith J. Recording growth and development in children with inflammatory bowel disease. BMJ. 1989 May 13;298(6683):1312–1313. [PMC free article] [PubMed]
  • Kirschner BS, Klich JR, Kalman SS, deFavaro MV, Rosenberg IH. Reversal of growth retardation in Crohn's disease with therapy emphasizing oral nutritional restitution. Gastroenterology. 1981 Jan;80(1):10–15. [PubMed]
  • McCaffery TD, Nasr K, Lawrence AM, Kirsner JB. Severe growth retardation in children with inflammatory bowel disease. Pediatrics. 1970 Mar;45(3):386–393. [PubMed]
  • Belli DC, Seidman E, Bouthillier L, Weber AM, Roy CC, Pletincx M, Beaulieu M, Morin CL. Chronic intermittent elemental diet improves growth failure in children with Crohn's disease. Gastroenterology. 1988 Mar;94(3):603–610. [PubMed]
  • Kanof ME, Lake AM, Bayless TM. Decreased height velocity in children and adolescents before the diagnosis of Crohn's disease. Gastroenterology. 1988 Dec;95(6):1523–1527. [PubMed]
  • Aiges H, Markowitz J, Rosa J, Daum F. Home nocturnal supplemental nasogastric feedings in growth-retarded adolescents with Crohn's disease. Gastroenterology. 1989 Oct;97(4):905–910. [PubMed]
  • Amarnath RP, Fleming CR, Perrault J. Home parenteral nutrition in chronic intestinal diseases: its effect on growth and development. J Pediatr Gastroenterol Nutr. 1987 Jan-Feb;6(1):89–95. [PubMed]
  • Layden T, Rosenberg F, Nemchausky G, Elson C, Rosenberg I. Reversal of growth arrest in adolescents with Crohn's disease after parenteral alimentation. Gastroenterology. 1976 Jun;70(6):1017–1021. [PubMed]
  • Kirschner BS, Sutton MM. Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease. Gastroenterology. 1986 Oct;91(4):830–836. [PubMed]
  • Grill BB, Lange R, Markowitz R, Hillemeier AC, McCallum RW, Gryboski JD. Delayed gastric emptying in children with Crohn's disease. J Clin Gastroenterol. 1985 Jun;7(3):216–226. [PubMed]
  • Giaffer MH, North G, Holdsworth CD. Controlled trial of polymeric versus elemental diet in treatment of active Crohn's disease. Lancet. 1990 Apr 7;335(8693):816–819. [PubMed]
  • Seidman EG. Nutritional management of inflammatory bowel disease. Gastroenterol Clin North Am. 1989 Mar;18(1):129–155. [PubMed]
  • Gotlin RW, Dubois RS. Nyctohemeral growth hormone levels in children with growth retardation and inflammatory bowel disease. Gut. 1973 Mar;14(3):191–195. [PMC free article] [PubMed]
  • Chong SK, Grossman A, Walker-Smith JA, Rees LH. Endocrine dysfunction in children with Crohn's disease. J Pediatr Gastroenterol Nutr. 1984 Sep;3(4):529–534. [PubMed]
  • Farthing MJ, Campbell CA, Walker-Smith J, Edwards CR, Rees LH, Dawson AM. Nocturnal growth hormone and gonadotrophin secretion in growth retarded children with Crohn's disease. Gut. 1981 Nov;22(11):933–938. [PMC free article] [PubMed]
  • Pimstone BL, Barbezat G, Hansen JD, Murray P. Studies on growth hormone secretion in protein-calorie malnutrition. Am J Clin Nutr. 1968 May;21(5):482–487. [PubMed]
  • Green JR, O'Donoghue DP, Edwards CR, Dawson AM. A case of apparent hypopituitarism complicating chronic inflammatory bowel disease in childhood and adolescence. Acta Paediatr Scand. 1977 Sep;66(5):643–647. [PubMed]
  • Alperstein G, Daum F, Fisher SE, Aiges H, Markowitz J, Becker J, So H, Schwartz D, Silverberg M, Schneider K. Linear growth following surgery in children and adolescents with Crohn's disease: relationship to pubertal status. J Pediatr Surg. 1985 Apr;20(2):129–133. [PubMed]
  • McLain BI, Davidson PM, Stokes KB, Beasley SW. Growth after gut resection for Crohn's disease. Arch Dis Child. 1990 Jul;65(7):760–762. [PMC free article] [PubMed]
  • Davies G, Evans CM, Shand WS, Walker-Smith JA. Surgery for Crohn's disease in childhood: influence of site of disease and operative procedure on outcome. Br J Surg. 1990 Aug;77(8):891–894. [PubMed]
  • Oliff A, Defeo-Jones D, Boyer M, Martinez D, Kiefer D, Vuocolo G, Wolfe A, Socher SH. Tumors secreting human TNF/cachectin induce cachexia in mice. Cell. 1987 Aug 14;50(4):555–563. [PubMed]
  • Torti FM, Dieckmann B, Beutler B, Cerami A, Ringold GM. A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science. 1985 Aug 30;229(4716):867–869. [PubMed]
  • Lee MD, Zentella A, Vine W, Pekala PH, Cerami A. Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6. Proc Natl Acad Sci U S A. 1987 May;84(9):2590–2594. [PMC free article] [PubMed]
  • Evans RD. Gastric effects of cytokines. Anaesthesia. 1989 Jun;44(6):518–518. [PubMed]
  • Michie HR, Sherman ML, Spriggs DR, Rounds J, Christie M, Wilmore DW. Chronic TNF infusion causes anorexia but not accelerated nitrogen loss. Ann Surg. 1989 Jan;209(1):19–24. [PMC free article] [PubMed]
  • Fong Y, Moldawer LL, Marano M, Wei H, Barber A, Manogue K, Tracey KJ, Kuo G, Fischman DA, Cerami A, et al. Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. Am J Physiol. 1989 Mar;256(3 Pt 2):R659–R665. [PubMed]
  • Brenner DA, Buck M, Feitelberg SP, Chojkier M. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. J Clin Invest. 1990 Jan;85(1):248–255. [PMC free article] [PubMed]
  • Milenkovic L, Rettori V, Snyder GD, Beutler B, McCann SM. Cachectin alters anterior pituitary hormone release by a direct action in vitro. Proc Natl Acad Sci U S A. 1989 Apr;86(7):2418–2422. [PMC free article] [PubMed]
  • Walton PE, Cronin MJ. Tumor necrosis factor-alpha inhibits growth hormone secretion from cultured anterior pituitary cells. Endocrinology. 1989 Aug;125(2):925–929. [PubMed]

Articles from Gut are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...