• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of ajhgLink to Publisher's site
Am J Hum Genet. Apr 1999; 64(4): 1177–1185.
PMCID: PMC1377842

A note on power approximations for the transmission/disequilibrium test.

Abstract

The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.

Full Text

The Full Text of this article is available as a PDF (235K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bellivier F, Leboyer M, Courtet P, Buresi C, Beaufils B, Samolyk D, Allilaire JF, Feingold J, Mallet J, Malafosse A. Association between the tryptophan hydroxylase gene and manic-depressive illness. Arch Gen Psychiatry. 1998 Jan;55(1):33–37. [PubMed]
  • Blackwelder WC, Elston RC. A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol. 1985;2(1):85–97. [PubMed]
  • Camp NJ. Genomewide transmission/disequilibrium testing--consideration of the genotypic relative risks at disease loci. Am J Hum Genet. 1997 Dec;61(6):1424–1430. [PMC free article] [PubMed]
  • Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996 Sep 13;273(5281):1516–1517. [PubMed]
  • Schaid DJ. Transmission disequilibrium, family controls, and great expectations. Am J Hum Genet. 1998 Oct;63(4):935–941. [PMC free article] [PubMed]
  • Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet. 1993 Mar;52(3):506–516. [PMC free article] [PubMed]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...