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Am J Hum Genet. Jan 1999; 64(1): 24–30.
PMCID: PMC1377698

Concerted evolution: molecular mechanism and biological implications.

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Selected References

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  • Abdulkarim F, Hughes D. Homologous recombination between the tuf genes of Salmonella typhimurium. J Mol Biol. 1996 Jul 26;260(4):506–522. [PubMed]
  • Amstutz H, Munz P, Heyer WD, Leupoid U, Kohli J. Concerted evolution of tRNA genes: intergenic conversion among three unlinked serine tRNA genes in S. pombe. Cell. 1985 Apr;40(4):879–886. [PubMed]
  • Arnheim N, Krystal M, Schmickel R, Wilson G, Ryder O, Zimmer E. Molecular evidence for genetic exchanges among ribosomal genes on nonhomologous chromosomes in man and apes. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7323–7327. [PMC free article] [PubMed]
  • Benedict MQ, Levine BJ, Ke ZX, Cockburn AF, Seawright JA. Precise limitation of concerted evolution to ORFs in mosquito Hsp82 genes. Insect Mol Biol. 1996 Feb;5(1):73–79. [PubMed]
  • Blattner FR, Plunkett G, 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, et al. The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453–1462. [PubMed]
  • Brunner AM, Schimenti JC, Duncan CH. Dual evolutionary modes in the bovine globin locus. Biochemistry. 1986 Sep 9;25(18):5028–5035. [PubMed]
  • Carranza S, Giribet G, Ribera C, Baguñ, Riutort M. Evidence that two types of 18S rDNA coexist in the genome of Dugesia (Schmidtea) mediterranea (Platyhelminthes, Turbellaria, Tricladida). Mol Biol Evol. 1996 Jul;13(6):824–832. [PubMed]
  • Charlesworth B, Sniegowski P, Stephan W. The evolutionary dynamics of repetitive DNA in eukaryotes. Nature. 1994 Sep 15;371(6494):215–220. [PubMed]
  • Coen E, Strachan T, Dover G. Dynamics of concerted evolution of ribosomal DNA and histone gene families in the melanogaster species subgroup of Drosophila. J Mol Biol. 1982 Jun 15;158(1):17–35. [PubMed]
  • Copenhaver GP, Pikaard CS. Two-dimensional RFLP analyses reveal megabase-sized clusters of rRNA gene variants in Arabidopsis thaliana, suggesting local spreading of variants as the mode for gene homogenization during concerted evolution. Plant J. 1996 Feb;9(2):273–282. [PubMed]
  • Dover GA. Evolution of genetic redundancy for advanced players. Curr Opin Genet Dev. 1993 Dec;3(6):902–910. [PubMed]
  • Dover GA, Linares AR, Bowen T, Hancock JM. Detection and quantification of concerted evolution and molecular drive. Methods Enzymol. 1993;224:525–541. [PubMed]
  • Elder JF, Jr, Turner BJ. Concerted evolution of repetitive DNA sequences in eukaryotes. Q Rev Biol. 1995 Sep;70(3):297–320. [PubMed]
  • Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496–512. [PubMed]
  • Goodman M. The genomic record of Humankind's evolutionary roots. Am J Hum Genet. 1999 Jan;64(1):31–39. [PMC free article] [PubMed]
  • Heix J, Grummt I. Species specificity of transcription by RNA polymerase I. Curr Opin Genet Dev. 1995 Oct;5(5):652–656. [PubMed]
  • Hibner BL, Burke WD, Eickbush TH. Sequence identity in an early chorion multigene family is the result of localized gene conversion. Genetics. 1991 Jul;128(3):595–606. [PMC free article] [PubMed]
  • Hillis DM, Moritz C, Porter CA, Baker RJ. Evidence for biased gene conversion in concerted evolution of ribosomal DNA. Science. 1991 Jan 18;251(4991):308–310. [PubMed]
  • Jinks-Robertson S, Petes TD. Experimental determination of rates of concerted evolution. Methods Enzymol. 1993;224:631–646. [PubMed]
  • Koop BF, Miyamoto MM, Embury JE, Goodman M, Czelusniak J, Slightom JL. Nucleotide sequence and evolution of the orangutan epsilon globin gene region and surrounding Alu repeats. J Mol Evol. 1986;24(1-2):94–102. [PubMed]
  • Lan R, Reeves PR. Recombination between rRNA operons created most of the ribotype variation observed in the seventh pandemic clone of Vibrio cholerae. Microbiology. 1998 May;144(Pt 5):1213–1221. [PubMed]
  • Liao D, Pavelitz T, Kidd JR, Kidd KK, Weiner AM. Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion. EMBO J. 1997 Feb 3;16(3):588–598. [PMC free article] [PubMed]
  • Liao D, Pavelitz T, Weiner AM. Characterization of a novel class of interspersed LTR elements in primate genomes: structure, genomic distribution, and evolution. J Mol Evol. 1998 Jun;46(6):649–660. [PubMed]
  • Liao D, Weiner AM. Concerted evolution of the tandemly repeated genes encoding primate U2 small nuclear RNA (the RNU2 locus) does not prevent rapid diversification of the (CT)n.(GA)n microsatellite embedded within the U2 repeat unit. Genomics. 1995 Dec 10;30(3):583–593. [PubMed]
  • Matera AG, Weiner AM, Schmid CW. Structure and evolution of the U2 small nuclear RNA multigene family in primates: gene amplification under natural selection? Mol Cell Biol. 1990 Nov;10(11):5876–5882. [PMC free article] [PubMed]
  • Murti JR, Bumbulis M, Schimenti JC. High-frequency germ line gene conversion in transgenic mice. Mol Cell Biol. 1992 Jun;12(6):2545–2552. [PMC free article] [PubMed]
  • Nei M, Gu X, Sitnikova T. Evolution by the birth-and-death process in multigene families of the vertebrate immune system. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7799–7806. [PMC free article] [PubMed]
  • Nenoi M, Mita K, Ichimura S, Kawano A. Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. Genetics. 1998 Feb;148(2):867–876. [PMC free article] [PubMed]
  • Ohta T, Dover GA. Population genetics of multigene families that are dispersed into two or more chromosomes. Proc Natl Acad Sci U S A. 1983 Jul;80(13):4079–4083. [PMC free article] [PubMed]
  • Pavelitz T, Rusché L, Matera AG, Scharf JM, Weiner AM. Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus. EMBO J. 1995 Jan 3;14(1):169–177. [PMC free article] [PubMed]
  • Polanco C, González AI, de la Fuente, Dover GA. Multigene family of ribosomal DNA in Drosophila melanogaster reveals contrasting patterns of homogenization for IGS and ITS spacer regions. A possible mechanism to resolve this paradox. Genetics. 1998 May;149(1):243–256. [PMC free article] [PubMed]
  • Schimenti JC. Mice and the role of unequal recombination in gene-family evolution. Am J Hum Genet. 1999 Jan;64(1):40–45. [PMC free article] [PubMed]
  • Schlötterer C, Tautz D. Chromosomal homogeneity of Drosophila ribosomal DNA arrays suggests intrachromosomal exchanges drive concerted evolution. Curr Biol. 1994 Sep 1;4(9):777–783. [PubMed]
  • Swanson WJ, Vacquier VD. Concerted evolution in an egg receptor for a rapidly evolving abalone sperm protein. Science. 1998 Jul 31;281(5377):710–712. [PubMed]

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